PD-L1/B7-H1 Protein 9049-B7-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemPD-L1/B7-H1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $438.00Supplier Page View Company Product Page
Catalog Number9049-B7-100
Size100 ug
ApplicationsBinding Activity
Conjugate/TagUnconjugated
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 31-41 kDa, reducing conditions
Theoretical: 26 kDa
SpeciesHuman
Molecule NamePD-L1/B7-H1
Source/Expression SystemHEK293-derived Recombinant Human PD-L1/B7-H1 His-tag Protein, CF
NCBI Full Gene NameCD274 molecule
NCBI Gene AliaseshPD-L1, B7H1, PDL1, PD-L1, PDCD1L1, B7-H, PDCD1LG1
FormatLyophilized from a 0.2 µm filtered solution in PBS
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 100 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) The co-delivery of Programmed Death 1 ligands enhances and prolongs rAAV-mediated gene expression in pre-immunized miceGene TherapyJanuary 9, 2026Piia Käyhty, Tiina Nieminen, Reetta A. E. Eriksson, Ritva Tumelius, Ahmed Tawfek, Svetlana Laidinen, Anna-Kaisa Ruotsalainen, Aubrey Bailey, Lionel Galibert, Hanna P. Lesch, et al.mouse sera using the same method. For antibody capture, plates were coated with recombinant PD-L1 (cat# 9049-B7-100, R&D Systems) or PD-L2 (cat# 9075-PL-100, R&D Systems) proteins in sodium bicarbonate coating buffer

(2) Imaging PD-L1 in the brain—Journey from the lab to the clinicNeuro-OncologyFebruary 10, 2025Dawoud Dar, Magdalena Rodak, Chiara Da Pieve, Izabela Gorczewska, Gitanjali Sharma, Ewa Chmielik, Marcin Niedbala, Pawel Bzowski, Andrea d’Amico, Barbara Bobek-Billewicz, et al.following the method described in the literature22 using the recombinant human PD-L1/B7-H1 His-Tag protein (9049-B7-100, Bio-Techne) and HisPur Ni-NTA magnetic beads (Thermo Fisher Scientific). The specificity of 89Zr-DFO-Atezolizumab

(3) Novel PD-L1-Targeted Phenyl-Pyrazolone Derivatives with Antioxidant PropertiesMoleculesApril 15, 2023Romain Regnault, Frédérique Klupsch, Hassiba El-Bouazzati, Romain Magnez, Raphaël Le Biannic, Natascha Leleu-Chavain, Hania Ahouari, Hervé Vezin, Régis Millet, Jean-François Goossens, et al.with red and blue filters. Recombinant Human PD-L1 (rhPD-L1) His-tag protein (R&D Systems, reference #9049-B7-100), diluted to 200 nM in PBS-T buffer (supplied by the vendor), was labeled with Monolith His-Tag Labeling

(4) A Potential Off-Target Effect of the Wnt/β-Catenin Inhibitor KYA1797K: PD-L1 Binding and Checkpoint InhibitionBiomedicine HubJanuary 19, 2023Xavier Thuru, Romain Magnez, Gérard Vergoten, Christian Baillyequipped with red and blue filter sets. Recombinant Human PD-L1 His-tag protein (R&D Systems, reference #9049-B7-100), diluted to 200 nM in PBS-T buffer (supplied by the vendor), was labeled with Monolith His-Tag Labeling

(5) Development of the Novel Bifunctional Fusion Protein BR102 That Simultaneously Targets PD-L1 and TGF-β for Anticancer ImmunotherapyCancersOctober 10, 2022Wu ZH, Li N, Gao ZZ, Chen G, Nie L, Zhou YQ, Jiang MZ, Chen Y, Chen J, Mei XF, et al.

(6) Pyrazolones as inhibitors of immune checkpoint blocking the PD-1/PD-L1 interactionEuropean journal of medicinal chemistryJune 5, 2022Le Biannic R, Magnez R, Klupsch F, Leleu-Chavain N, Thiroux B, Tardy M, El Bouazzati H, Dezitter X, Renault N, Vergoten G, et al.

(7) Expression of plant-produced anti-PD-L1 antibody with anoikis sensitizing activity in human lung cancer cells via., suppression on epithelial-mesenchymal transitionPloS oneJanuary 1, 2022Phetphoung T, Malla A, Rattanapisit K, Pisuttinusart N, Damrongyot N, Joyjamras K, Chanvorachote P, Phakham T, Wongtangprasert T, Strasser R, et al.

(8) A human CD137×PD-L1 bispecific antibody promotes anti-tumor immunity via context-dependent T cell costimulation and checkpoint blockadeNature communicationsJuly 21, 2021Geuijen C, Tacken P, Wang LC, Klooster R, van Loo PF, Zhou J, Mondal A, Liu YB, Kramer A, Condamine T, et al.

(9) Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat SheetsACS NanoFebruary 23, 2021Trixy Fang, Jonatan Alvelid, Joel Spratt, Elena Ambrosetti, Ilaria Testa, Ana I. Teixeira(ThermoFisher Scientific) according to manufacturer’s instructions. PD-L1 Conjugation Recombinant human PD-L1 His-tag (9049-B7-100, R&D Systems) was reconstituted with 1 × PBS, pH 6.3 according to manufacturer’s guidelines. The protein

(10) Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1Nature communicationsFebruary 22, 2021Park JJ, Thi EP, Carpio VH, Bi Y, Cole AG, Dorsey BD, Fan K, Harasym T, Iott CL, Kadhim S, et al.

(11) Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancermAbsJanuary 1, 2021Schofield DJ, Percival-Alwyn J, Rytelewski M, Hood J, Rothstein R, Wetzel L, McGlinchey K, Adjei G, Watkins A, Machiesky L, et al.immobilized on both flow cells. His-tagged recombinant human PD-L1 protein (R&D Systems, catalog no. 9049-B7-100) at 2 µg/mL or recombinant mouse CTLA-4 protein (R&D Systems, catalog no. 434-CT-200/CF) at 0.125 µg/mL

(12) Affinity maturation of antibodies by combinatorial codon mutagenesis versus error-prone PCRmAbsJanuary 1, 2020Simons JF, Lim YW, Carter KP, Wagner EK, Wayham N, Adler AS, Johnson DS.protein and were procured in a lyophilized form from either R&D Systems (PD-1, 8986-PD-100; PD-L1, 9049-B7-100) (Minneapolis, MN) or Acro Biosystems (CTLA-4, CT4-H5229; OX40, OX0-H5224) (Newark, DE). Antigens were

(13) Rapid PD-L1 detection in tumors with PET using a highly specific peptideBiochemical and biophysical research communicationsJanuary 29, 2017Chatterjee S, Lesniak WG, Miller MS, Lisok A, Sikorska E, Wharram B, Kumar D, Gabrielson M, Pomper MG, Gabelli SB, et al.

(14) PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus IICell reportsJanuary 1, 0001Sun L, Wang Y, Wang X, Navarro-Corcuera A, Ilyas S, Jalan-Sakrikar N, Gan C, Tu X, Shi Y, Tu K, et al.

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PD-L1/B7-H1 Protein

PD-L1/B7-H1 Protein

PD-L1/B7-H1 Protein

PD-L1/B7-H1 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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PD-L1/B7-H1 Protein from R&D Systems, a Bio-Techne Brand

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