Recombinant Mouse IL-6/IL-6R alpha Protein Chimera 9038-SR-025 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Mouse IL-6/IL-6R alpha Protein Chimera
CompanyR&D Systems, a Bio-Techne Brand
Price $479.00Supplier Page View Company Product Page
Catalog Number9038-SR-025
Size25 ug
ApplicationsBioactivity
Conjugate/TagUnconjugated
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 70-87 kDa, reducing conditions
Theoretical: 60 kDa
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
SpeciesMouse
Molecule NameIL-6/IL-6R alpha Complex
Source/Expression SystemNS0-derived Recombinant Mouse IL-6/IL-6R alpha Protein Chimera
NCBI Full Gene Nameinterleukin 6 receptor, alpha, interleukin 6
NCBI Gene AliasesIL-6R-alpha, CD126, Il-6, IL-6RA, Il6r, IL-6R
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) IL‐6 Signalling to Responding T Cells Is Key to Calcitonin Gene‐Related Peptide‐Exposed Endothelial Cell Enhancement of Th17 Immunity During Langerhans Cell Antigen PresentationImmunologyApril 1, 2025Wanhong Ding, Cameron Moattari, Lori L. Stohl, John A. Wagner, Xi K. Zhou, Richard D. Granstein(Swampscott, MA). Murine IL-6/IL-6Rα complex protein (IL-6/IL-6Rα) was purchased from R&D Systems (cat# 9038-SR-025). Rat anti-mouse CD31 mAb (clone MEC 13.3, cat# 553369) and rat anti-mouse CD45 mAb (clone 30-F11, cat#

(2) Guidelines for mouse and human DC generationEuropean journal of immunologyNovember 1, 2023Lutz MB, Ali S, Audiger C, Autenrieth SE, Berod L, Bigley V, Cyran L, Dalod M, Dörrie J, Dudziak D, et al.

(3) Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritisCell Reports MedicineOctober 17, 2023Mengmeng Liang, Ke Wang, Xiaoyu Wei, Xiaoshan Gong, Hao Tang, Hao Xue, Jing Wang, Pengbin Yin, Licheng Zhang, Zaisong Ma, et al.671-GP-100 Recombinant mouse gp130Fc,R&D Systems,Cat# 468-MG-100 Recombinant mouse hyper IL6,R&D Systems,Cat# 9038-SR-025 Penicillin-streptomycin,Hyclone,Cat# SV30010 Complete Freund’s Adjuvant,Chondrex,Cat# 7001 Incomplete

(4) The Alzheimer's disease-linked protease BACE1 modulates neuronal IL-6 signaling through shedding of the receptor gp130Molecular neurodegenerationFebruary 21, 2023Müller SA, Shmueli MD, Feng X, Tüshaus J, Schumacher N, Clark R, Smith BE, Chi A, Rose-John S, Kennedy ME, et al.

(5) Discovery and characterization of a monoclonal antibody targeting a conformational epitope of IL-6/IL-6Rα to inhibit IL-6/ IL-6Rα/gp130 hexameric signaling complex formationmAbsJanuary 1, 2022Chou CC, Hua KT, Chen MW, Wu CJ, Hsu CH, Wang JT, Hsiao M, Wei LH.

(6) The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signalingeLifeAugust 26, 2021Dong J, Viswanathan S, Adami E, Schafer S, Kuthubudeen FF, Widjaja AA, Cook SA.

(7) The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cellsImmunityFebruary 9, 2021Yousif AS, Ronsard L, Shah P, Omatsu T, Sangesland M, Bracamonte Moreno T, Lam EC, Vrbanac VD, Balazs AB, Reinecker HC, et al.penicillin–streptomycin) or SF containing freshly 400ng/ml IL6-sIL6Rα (= Hyper-IL6; Fischer et al., 1997) (9038-SR-025, R&D Systems). After this culture period, the cells were pelleted, fixed and then permeabilized to enable

(8) Reactive Myelopoiesis Triggered by Lymphodepleting Chemotherapy Limits the Efficacy of Adoptive T Cell TherapyMolecular therapy : the journal of the American Society of Gene TherapyOctober 7, 2020Innamarato P, Kodumudi K, Asby S, Schachner B, Hall M, Mackay A, Wiener D, Beatty M, Nagle L, Creelan BC, et al.

(9) Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistanceNature communicationsMay 3, 2017Xu E, Pereira MMA, Karakasilioti I, Theurich S, Al-Maarri M, Rappl G, Waisman A, Wunderlich FT, Brüning JC.containing freshly prepared 70 ng ml−1 IL-6 (406-ML-005, R&D Systems), 200 ng ml−1 IL-6—IL-6Rα complex (9038-SR-025, R&D Systems) or 130 ng ml−1 sIL-6Rα alone (1830-SR-025, R&D Systems). After stimulation (20 min), cells

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IL-6/IL-6R alpha Complex Protein

IL-6/IL-6R alpha Complex Protein

IL-6/IL-6R alpha Complex Protein

Recombinant Mouse IL-6/IL-6R alpha Protein Chimera from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Mouse IL-6/IL-6R alpha Protein Chimera from R&D Systems, a Bio-Techne Brand

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