IL-21 Protein 8879-IL-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemIL-21 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $322.00Supplier Page View Company Product Page
Catalog Number8879-IL-010/CF
Size10 ug (also 50 ug)
ApplicationsBioactivity
Conjugate/TagUnconjugated
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 17 kDa, reducing conditions
Theoretical: 15 kDa
SpeciesHuman
Molecule NameIL-21
Source/Expression SystemE. coli-derived Recombinant Human IL-21 Protein, CF
NCBI Full Gene Nameinterleukin 21
NCBI Gene AliasesZa11, IL-21, CVID11
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, <= -20 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 10 ug (also 50 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) A Novel R140S γc Variant Alters Cellular Distribution, Reduces Surface Expression, and Impairs Cytokine Signaling in Atypical X-SCIDJ Clin ImmunolAugust 2, 2025Lulu Dong, Bijun Sun, Qing Min, Xin Meng, Yaxuan Li, Meiping Yu, Zichao Wen, Xuzhe Wu, Ziying Hu, Runyun Zhang, et al./mL, #202-IL-010/CF, R&D Systems, USA), α-CD40 (200 ng/mL, #555587, BD Biosciences, USA), IL-21 (50 ng/mL, #8879-IL-010/CF, R&D Systems, USA), IL-4 (25 ng/mL, #BT-004-010, R&D Systems, USA), and α-IgM (2 µg/mL, #314502, Biolegend,

(2) Refined analytical pipeline for the pharmacodynamic assessment of T-cell responses to vaccine antigensFrontiers in ImmunologyApril 24, 2024Michail Angelos Pavlidis, Nadia Viborg, Mads Lausen, Birgitte Rønø, Daniela Kleine-Kohlbrecherinterleukin (IL)-15 (10 ng/ml, R&D Systems, cat. #247-ILB-005/CF) and IL-21 (50 ng/ml, R&D Systems, cat. #8879-IL-010/CF). Short peptides (8mers or 9mers) were diluted in culture medium to 3.34 μg/ml while long peptides (27mers)

(3) Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3CancersFebruary 6, 2023Tate T, Matsumoto S, Nemoto K, Leisegang M, Nagayama S, Obama K, Nakamura Y, Kiyotani K.

(4) PD-1(high)CXCR5(-)CD4(+) peripheral helper T cells promote CXCR3(+) plasmablasts in human acute viral infectionCell reportsJanuary 31, 2023Asashima H, Mohanty S, Comi M, Ruff WE, Hoehn KB, Wong P, Klein J, Lucas C, Cohen I, Coffey S, et al.

(5) CD27-Expressing Xenoantigen-Expanded Human Regulatory T Cells Are Efficient in Suppressing Xenogeneic Immune ResponseCell transplantationJanuary 1, 2023Cao L, Ma X, Zhang J, Yang M, He Z, Yang C, Li S, Rong P, Wang W.

(6) Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis CNature communicationsSeptember 16, 2022Nishio A, Hasan S, Park H, Park N, Salas JH, Salinas E, Kardava L, Juneau P, Frumento N, Massaccesi G, et al.

(7) DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cellsScience advancesAugust 26, 2022Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, et al.

(8) Induced Human Regulatory T Cells Express the Glucagon-like Peptide-1 ReceptorCellsAugust 19, 2022Rode AKO, Buus TB, Mraz V, Al-Jaberi FAH, Lopez DV, Ford SL, Hennen S, Eliasen IP, Klewe IV, Gharehdaghi L, et al.

(9) Over-Expression of Allograft Inflammatory Factor-1 (AIF-1) in Patients with Rheumatoid ArthritisBiomoleculesJuly 16, 2020Piotrowska K, Słuczanowska-Głabowska S, Kurzawski M, Dziedziejko V, Kopytko P, Paczkowska E, Rogińska D, Safranow K, Machaliński B, Pawlik A.

(10) Association of circulating SLAMF7⁺Tfh1 cells with IgG4 levels in patients with IgG4-related diseaseBMC immunologyJune 1, 2020Higashioka K, Ota Y, Maehara T, Moriyama M, Ayano M, Mitoma H, Akahoshi M, Arinobu Y, Horiuchi T, Nakamura S, et al.

(11) IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissueMucosal immunologyMay 1, 2020Xu R, Shears RK, Sharma R, Krishna M, Webb C, Ali R, Wei X, Kadioglu A, Zhang Q.

(12) B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody responseScience advancesApril 1, 2020Gan H, Shen T, Chupp DP, Taylor JR, Sanchez HN, Li X, Xu Z, Zan H, Casali P.

(13) IL-21 in Conjunction with Anti-CD40 and IL-4 Constitutes a Potent Polyclonal B Cell Stimulator for Monitoring Antigen-Specific Memory B CellsCellsFebruary 13, 2020Franke F, Kirchenbaum GA, Kuerten S, Lehmann PV.

(14) TCDD-mediated suppression of naïve human B cell IgM secretion involves aryl hydrocarbon receptor-mediated reduction in STAT3 serine 727 phosphorylation and is restored by interferon-γCellular signallingJanuary 1, 2020Blevins LK, Zhou J, Crawford R, Kaminski NE.

(15) Inhibition of T Helper Cell Differentiation by Tacrolimus or Sirolimus Results in Reduced B-Cell Activation: Effects on T Follicular Helper CellsTransplantation proceedingsDecember 1, 2019Kraaijeveld R, Li Y, Yan L, de Leur K, Dieterich M, Peeters AMA, Wang L, Shi Y, Baan CC.

(16) Juvenile idiopathic arthritis associated with a mutation in GATA3Arthritis research & therapyJune 25, 2019Patrick AE, Wang W, Brokamp E, Graham TB, Aune TM, Duis JB.

(17) Locus suicide recombination actively occurs on the functionally rearranged IgH allele in B-cells from inflamed human lymphoid tissuesPLoS geneticsJune 1, 2019Dalloul I, Boyer F, Dalloul Z, Pignarre A, Caron G, Fest T, Chatonnet F, Delaloy C, Durandy A, Jeannet R, et al.

(18) The KDM4A/KDM4C/NF-κB and WDR5 epigenetic cascade regulates the activation of B cellsNucleic acids researchJune 20, 2018Hung KH, Woo YH, Lin IY, Liu CH, Wang LC, Chen HY, Chiang BL, Lin KI.

(19) Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphomaOncotargetMarch 6, 2018Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod RAF, Drexler HG.

(20) Effective screening of T cells recognizing neoantigens and construction of T-cell receptor-engineered T cellsOncotargetFebruary 16, 2018Kato T, Matsuda T, Ikeda Y, Park JH, Leisegang M, Yoshimura S, Hikichi T, Harada M, Zewde M, Sato S, et al.

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Recombinant Human IL-21 Protein, CF

IL-21 Protein

IL-21 Protein

IL-21 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (26)

Reviews

IL-21 Protein from R&D Systems, a Bio-Techne Brand

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