Recombinant Human IFN-beta Protein 8499-IF-010 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IFN-beta Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $292.00Supplier Page View Company Product Page
Catalog Number8499-IF-010
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Gene AliasesIFN-beta, IFF, IFNB, IFB
NCBI Full Gene Nameinterferon beta 1
Source/Expression SystemCHO-derived Recombinant Human IFN-beta Protein
Molecule NameIFN-beta
SpeciesHuman
Molecular WeightObserved: 20-26 kDa, reducing conditions
Theoretical: 20 kDa
Purity>95%, by SDS-PAGE with silver staining
FormatLyophilized from a 0.2 µm filtered solution in Citric Acid and CHAPS with BSA as a carrier protein
Size10 ug (also 50 ug, 200 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Pericentromeric Transcription of Novel Pathogen-Related Human GPS Genes in Cancers is Regulated by C19MC miRNAs, CEBPB, IFN-γ, and IFN-βResearchSquareFebruary 4, 2026Goodwin Jinesh, Isha Godwin, Marco Napoli, Elsa Flores, Andrew Brohlconditions: IFN-γ (R&D Systems, Cat.# 285-IF-100, 1nM / 17 ng/ml for 24 h.), IFN-β (R&D Systems, Cat.# 8499-IF-010, 1nM / 20 ng/ml for 24 h.). Chemical reagents and treatment conditions: All-trans retinoic acid (ATRA)

(2) VILMIR is a trans -acting long noncoding RNA that enhances the host interferon response in human epithelial cellsJournal of VirologyJanuary 20, 2026Kristen John, Ethan Smith, Alexandra Istishin, Nasif Mahmood, Kayleigh Diveley, Tammy S. Tollison, Susan Carpenter, Xinxia Pengsaline and treated with fresh A549 media containing 1 ng/mL human IFN-β recombinant protein (R&D Systems 8499IF010) for 6 hours. Nuclear and cytoplasmic protein lysates of the cells were extracted using NE-PER Nuclear and Cytoplasmic Extraction Reagents

(3) Inhibition of PD-L1/PD-1 Checkpoint Increases NK Cell-Mediated Killing of Melanoma Cells in the Presence of Interferon-BetaCancers (Basel)December 5, 2025Anna Makowska, Lian Shen, Christina Nothbaum, Diana Panayotova-Dimitrova, Maria Feoktistova, Amir S. Yazdi, Udo KontnyReagents Human recombinant interferon-beta (IFNβ) was obtained from R&D System (New York, NY, USA, #8499-IF-010) and soluble, recombinant human TRAIL from Enzo Life Science (Paris, France). Antibodies used for flow cytometry

(4) ISG20 Restricts BK Polyomavirus Infection and Engages in Reciprocal Regulation with Viral Large T AntigenMicroorganismsNovember 6, 2025Yumin Hou, Chunlan Hu, Yejing Shi, Xiaohui Zhou, Tongyu Zhu, Nannan Wucells per well) overnight and treated with increasing doses of recombinant human IFN-β (R&D Systems, #8499-IF-010, Minneapolis, MN, USA) (10, 25, 50, 100, and 200 U/mL) for 24 h, after which the cells were collected

(5) Harnessing Notch Signaling to Enhance the Generation and Functionality of Human Conventional Type 1 Dendritic Cells for Cancer Immunotherapy ApplicationsCancer immunology researchSeptember 2, 2025Balan S, O'Brien L, Peros A, Wang X, Leal Rojas I, McClain C, Radford KJ, Bhardwaj N.

(6) Human long noncoding RNA VILMIR is induced by major respiratory viral infections and modulates the host interferon responseJournal of VirologyApril 15, 2025Kristen John, Ian Huntress, Ethan Smith, Hsuan Chou, Tammy S. Tollison, Sergio Covarrubias, Elisa Crisci, Susan Carpenter, Xinxia PengCells were treated with fresh A549 media with or without human IFN-β recombinant protein (R&D Systems 8499IF010) at the indicated concentrations. Cells were harvested at the indicated time points after treatment

(7) A tissue-scale strategy for sensing threats in barrier organsbioRxiv : the preprint server for biologyMarch 19, 2025Nguyen DH, Tian J, Shanahan SL, Wang CK, Jacks T, Wang X, Li P.

(8) Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-riboseThe EMBO JournalFebruary 25, 2025Daniel S Bejan, Rachel E Lacoursiere, Jonathan N Pruneda, Michael S CohenADPr),Sigma-Aldrich,A0752 β-NAD+,Sigma-Aldrich,N3014 ATP,Sigma-Aldrich,A2383 Benzonase,Millipore Sigma,70664 Recombinant Human IFN-beta,R&D Systems,8499IF010 Maltoheptaose,Sigma,M7753 Silver Stain Plus Kit,Bio-Rad,1610449 HisPur Ni-NTA resin,Thermo Scientific,88222 Software,Software,Software GraphPad

(9) 5′ terminal nucleotide determines the immunogenicity of IVT RNAsNucleic Acids ResearchJanuary 24, 2025Magdalena Wolczyk, Jacek Szymanski, Ivan Trus, Zara Naz, Tola Tame, Agnieszka Bolembach, Nila Roy Choudhury, Karolina Kasztelan, Juri Rappsilber, Andrzej Dziembowski, et al.curve was generated in parallel by serial dilutions of recombinant IFN-β standard in DMEM (R&D Systems #8499-IF-010 and #8234-MB-010). After overnight incubation (24 h), 20 μl of supernatants were mixed with 180 μl of

(10) Coronavirus nucleocapsid protein enhances the binding of p-PKCα to RACK1: Implications for inhibition of nucleocytoplasmic trafficking and suppression of the innate immune responsePLoS pathogensNovember 1, 2024Xue W, Chu H, Wang J, Sun Y, Qiu X, Song C, Tan L, Ding C, Liao Y.

(11) Toxicity and efficacy of type I interferons on the ocular surface: in vitro, animal, and clinical studiesThe ocular surfaceOctober 1, 2024Yun YI, Ko JH, Ryu JS, Kim S, Jeon HS, Kim N, Kim MK, Oh JY.

(12) STING Agonist Induced Innate Immune Responses Drive Anti-Respiratory Virus Activity In Vitro with Limited Antiviral Efficacy In VivoACS infectious diseasesSeptember 13, 2024Broeckel R, Browne A, Sucoloski S, Cantizani J, Simpson JK, Pesiridis S, Ramanjulu JM, Stokes N, Luthra P.following day, cells were infected and treated with compound as specified. Recombinant IFNβ (R&D Systems, 8499-IF-010) was resuspended and added to the media as indicated. For infection of the ALI tissues, cells were rinsed

(13) A new gene signature for endothelial senescence identifies self-RNA sensing by retinoic acid-inducible gene I as a molecular facilitator of vascular agingAging cellSeptember 1, 2024Guduric-Fuchs J, Pedrini E, Bertelli PM, McDonnell S, Pathak V, McLoughlin K, O'Neill CL, Stitt AW, Medina RJ.

(14) SAMD9L acts as an antiviral factor against HIV-1 and primate lentiviruses by restricting viral and cellular translationPLOS BiologyJuly 3, 2024Alexandre Legrand, Clara Dahoui, Clément De La Myre Mory, Kodie Noy, Laura Guiguettaz, Margaux Versapuech, Clara Loyer, Margaux Pillon, Mégane Wcislo, Laurent Guéguen, et al.cells were stimulated, or not, with IFN⍺2 (Tebu Bio, cat. 11100–1) or IFNβ (500 IU/ml, R&D Systems, 8499-IF-010) for 24 h prior lysis. The following antibodies were used: anti-Tubulin (Sigma, cat. T5168), anti-Actin

(15) Activation of ATF3 via the Integrated Stress Response Pathway Regulates Innate Immune Response to Restrict Zika VirusbioRxiv : the preprint server for biologyJuly 3, 2024Badu P, Baniulyte G, Sammons MA, Pager CT.

(16) N-MYC impairs innate immune signaling in high-grade serous ovarian carcinomaScience advancesMay 17, 2024Miranda A, Pattnaik S, Hamilton PT, Fuss MA, Kalaria S, Laumont CM, Smazynski J, Mesa M, Banville A, Jiang X, et al.

(17) Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein NefNature communicationsMay 7, 2024Prelli Bozzo C, Laliberté A, De Luna A, Pastorio C, Regensburger K, Krebs S, Graf A, Blum H, Volcic M, Sparrer KMJ, et al.

(18) Airway epithelial CD47 plays a critical role in inducing influenza virus-mediated bacterial super-infectionNature communicationsApril 30, 2024Moon S, Han S, Jang IH, Ryu J, Rha MS, Cho HJ, Yoon SS, Nam KT, Kim CH, Park MS, et al.

(19) T cell expressions of aberrant gene signatures and Co-inhibitory receptors (Co-IRs) as predictors of renal damage and lupus disease activityJournal of biomedical scienceApril 22, 2024Wang CM, Jan Wu YJ, Zheng JW, Huang LY, Tan KP, Chen JY.

(20) Human long noncoding RNA, VILMIR, is induced by major respiratory viral infections and modulates the host interferon responsebioRxivApril 2, 2024Kristen John, Ian Huntress, Ethan Smith, Hsuan Chou, Tammy S. Tollison, Sergio Covarrubias, Elisa Crisci, Susan Carpenter, Xinxia PengCells were treated with fresh A549 media with or without human IFN-β recombinant protein (R&D Systems™ 8499IF010) at the indicated concentrations. Cells were harvested at the indicated time points after treatment

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Recombinant Human IFN-beta Protein

IFN-beta Protein

IFN-beta Protein

Recombinant Human IFN-beta Protein from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human IFN-beta Protein from R&D Systems, a Bio-Techne Brand

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