Recombinant Human Sonic Hedgehog Protein, High Activity, CF 8908-SH-005/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Sonic Hedgehog Protein, High Activity, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $420.00Supplier Page View Company Product Page
Catalog Number8908-SH-005/CF
Size5 ug
FormatSupplied as a 0.2 µm filtered solution in MES, NaCl and CHAPS
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 18-24 kDa, reducing conditions
Theoretical: 20 kDa
Molecule NameSonic Hedgehog/Shh
Source/Expression SystemHEK293-derived Recombinant Human Sonic Hedgehog Protein, High Activity, CF
NCBI Full Gene Namesonic hedgehog signaling molecule
NCBI Gene AliasesHPE3, SMMCI, HHG1, TPT, HLP3, TPTPS, ShhNC, MCOPCB5
ApplicationsBioactivity
Conjugate/TagUnconjugated
SpeciesHuman
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary CiliaCellsSeptember 26, 2023Shi P, Tian J, Mallinger JC, Ling D, Deleyrolle LP, McIntyre JC, Caspary T, Breunig JJ, Sarkisian MR.(Calbiochem; Cat #566661), and recombinant human SHH (high-activity) (R&D Systems, Minneapolis, MN, USA; Cat #8908-SH-005/CF), and fixed after indicated treatment durations and processed as described below. Where indicated, cells

(2) Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen releaseNature communicationsNovember 29, 2021Li W, Wang L, Wierbowski BM, Lu M, Dong F, Liu W, Li S, Wang P, Salic A, Gong X.

(3) Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermatesActa neuropathologica communicationsAugust 16, 2021Gao FJ, Klinedinst D, Fernandez FX, Cheng B, Savonenko A, Devenney B, Li Y, Wu D, Pomper MG, Reeves RH.

(4) SLITRK5 is a negative regulator of hedgehog signaling in osteoblastsNature communicationsJuly 29, 2021Sun J, Shin DY, Eiseman M, Yallowitz AR, Li N, Lalani S, Li Z, Cung M, Bok S, Debnath S, et al.

(5) GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancerOncology reportsMarch 1, 2021Ichimiya S, Onishi H, Nagao S, Koga S, Sakihama K, Nakayama K, Fujimura A, Oyama Y, Imaizumi A, Oda Y, et al.

(6) PAUPAR and PAX6 sequentially regulate human embryonic stem cell cortical differentiationNucleic acids researchFebruary 26, 2021Xu Y, Xi J, Wang G, Guo Z, Sun Q, Lu C, Ma L, Wu Y, Jia W, Zhu S, et al.

(7) Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium HomeostasisCell stem cellOctober 1, 2020Kim JW, Yin X, Jhaldiyal A, Khan MR, Martin I, Xie Z, Perez-Rosello T, Kumar M, Abalde-Atristain L, Xu J, et al.

(8) Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cellsPloS oneJanuary 1, 2020Griffin SM, Pickard MR, Hawkins CP, Williams AC, Fricker RA.

(9) Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein KinaseMolecular cellNovember 21, 2019Su KH, Dai S, Tang Z, Xu M, Dai C.CellTiter-Blue® cell viability assay kit,Promega,Cat# G8081 Recombinant cholesteroylated human SHH-N proteins,R&D Systems,Cat# 8908-SH-005/CF AMP,Research Product International,Cat# A11240 ATP,Research Product International,Cat# A30030 Dorsomorphin dihydrochloride

(10) Structures of human Patched and its complex with native palmitoylated sonic hedgehogNatureAugust 1, 2018Qi X, Schmiege P, Coutavas E, Wang J, Li X.

(11) Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilageMatrix biology : journal of the International Society for Matrix BiologyApril 1, 2018Kurio N, Saunders C, Bechtold TE, Salhab I, Nah HD, Sinha S, Billings PC, Pacifici M, Koyama E.

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Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Recombinant Human Sonic Hedgehog Protein, High Activity, CF from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

Citations (11)

Reviews

Recombinant Human Sonic Hedgehog Protein, High Activity, CF from R&D Systems, a Bio-Techne Brand

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