Fig 1: The mixture of three ligands added to the normal culture induces a similar level of growth suppression as the CM of CD36+ FBs. (A) The addition of each recombinant protein to the MDA-MB-231 medium induced partial growth suppression. (B) The addition of each neutralizing antibody to the CM of CD36+ FBs interfered partially with the growth suppression. (C) Mixed recombinant proteins of SLIT3, PENK, and FBLN1 induced an additive growth suppression that was similar to the CM of CD36+ FBs. (D) Protein ligands induced apoptosis via the caspase-3 pathway after one day of treatment. * p < 0.05, ** p < 0.001.