Recombinant Human IFN-beta Protein, CF 8499-IF-010/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IFN-beta Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $292.00Supplier Page View Company Product Page
Catalog Number8499-IF-010/CF
Size10 ug
FormatLyophilized from a 0.2 µm filtered solution in Citric Acid and CHAPS
Purity>95%, by SDS-PAGE with silver staining
Molecular WeightObserved: 20-26 kDa, reducing conditions
Theoretical: 20 kDa
SpeciesHuman
Molecule NameIFN-beta
Source/Expression SystemCHO-derived Recombinant Human IFN-beta Protein, CF
NCBI Full Gene Nameinterferon beta 1
NCBI Gene AliasesIFN-beta, IFF, IFNB, IFB
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Quantifying the Dual Effect of Antitumor and Pro-Tumor Human Neutrophils on Natural Killer Cell Behaviors in a Microphysiological SystemACS Biomaterials Science & EngineeringApril 13, 2026Shuai Shao, Caroline N. Jones100 ng/mL lipopolysaccharide (LPS, Sigma-Aldrich, L2630), 50 ng/mL interferon-β (IFN-β, R&D Systems, 8499-IF-010/CF), and 50 ng/mL interferon-γ (IFN-γ, R&D Systems, 285-IF-100/CF). An N2-like (pro-tumor) phenotype was

(2) CD4 T-cell platform for delivering interferons as an antiviral countermeasure with a focus on SARS-CoV-2Mol MedMarch 28, 2026Xiaohe Liu, Marvin A. Ssemadaali, Harikrishnan Radhakrishnan, Juan Arredondo, Harold S. Javitz, Satya Dandekar, Parijat Bhatnagarthe engineered T cells. Recombinant human interferon (rhIFN) proteins from R&D systems (IFN-β [Cat# 8499-IF-010/CF], IFN-λ1 [Cat# 1598-IL-025/CF], IFN-λ2 [Cat# 8417-IL-025/CF]) and IFN-α2 from InvivoGen [Cat# rcyc-hifna2b]

(3) Toll like receptor agonist effects on human CD8+ T cell activation and expression of T cell checkpoint receptorsHum Vaccin ImmunotherDecember 18, 2025Donghwan Jeon, Jena E. Moseman, Ethan Hill, Douglas G. McNeelexperiments, PBMCs were stimulated with human IL-12 (R&D Systems 10,018-IL-010) or IFNβ (R&D Systems 8499-IF-010/CF) for one hour. HLA-A2 specific viral antigen peptides (CMV: NLVPMVATV, EBV: FLYALALLL) were then added

(4) Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3Nature communicationsAugust 29, 2025Zhu Y, Song Y, Kumar D, Jackson PK, Prasad BVV, Ding S.

(5) Mutation T9I in Envelope confers autophagy resistance to SARS-CoV-2 OmicroniScienceJuly 18, 2025Susanne Klute, Rayhane Nchioua, Arne Cordsmeier, Jyoti Vishwakarma, Lennart Koepke, Hala Alshammary, Christoph Jung, Maximilian Hirschenberger, Helene Hoenigsperger, Jana-Romana Fischer, et al.,Thermo Fisher Scientific,Cat#15630080 HEPES,Carl Roth,Cat#6763.1 HEPES pH 7.4,Sigma-Aldrich,Cat#H3375 IFN-β,R&D Systems,Cat#8499-IF-010/CF Immobilon-FL PVDF-Membrane,Merck,Cat#IPFL00010 L-glutamine,PAN-Biotech,Cat#P04-80100 Glycerol,Sigma-Aldrich,Cat#G5516 Glycerol,Sigma-Aldrich,Cat#49782 Guanidinium

(6) Protocol for assessing T cell receptor-mediated human T cell cytotoxicitySTAR ProtocJanuary 4, 2025Kathryne E. Marks, Ifeoluwakiisi Adejoorin, John Sowerby, Deepak A. Rao,Thermo Fisher Scientific,65-0850-84 Dynabeads human T-activator CD3/CD28,Thermo Fisher Scientific,11131D Recombinant human IFNβ,R&D Systems,8499-IF-010/CF Recombinant human IL-15,R&D Systems,BT-015 Fetal bovine serum,GeminiBio,100-106 "Gibco Penicillin-Streptomycin (10,000 U/mL

(7) Molluscum contagiosum virus protein MC089 inhibits interferon regulatory factor 3 activationJournal of General VirologyAugust 21, 2024Mariya Al Hamrashdi, Carla Sanchez Perez, Darya A. Haas, Jyoti Vishwakarma, Andreas Pichlmair, Andrew G. Bowie, Gareth Brady(InvivoGen # ant-nr). A twofold serial dilution of recombinant human IFNβ standard (R and D Systems # 8499-IF-010/CF) was prepared using DMEM with 10% FBS, 1% penicillin and normocin (100 µg ml−1). Supernatants were harvested

(8) Interferons prime the endothelium for toll-like receptor–mediated thrombin generationJournal of Thrombosis and HaemostasisApril 1, 2024Kelsey D. Sack, Nathan Eaton, Maneli Doroudian Tehrani, Robert FlaumenhaftIL-6/9570802, IL-1β/579402, TNFα/570102, IFNα/592704), IFNγ/570206; R&D Systems: IL-10/1064-ILB-010, IFNβ/8499-IF-010/CF, IFNε/9667-ME-025/CF, IFNω/11395–1) for 24 hours prior to 5 hour induction with poly(I:C) (Invivogen,

(9) CCR4-NOT differentially controls host versus virus poly(a)-tail length and regulates HCMV infectionEMBO reportsDecember 6, 2023Burgess HM, Grande R, Riccio S, Dinesh I, Winkler GS, Depledge DP, Mohr I.reagents" Human IL‐4,R&D Systems,6507‐IL‐010/CF Human IL‐12,R&D Systems,10018‐IL‐010 Human IFN‐beta,R&D Systems,8499‐IF‐010/CF actinomycin D,Fisher,AAJ60148LB0 qScript XLT,Quanta,95132‐500 SsoAdvanced SYBR green supermix,Bio‐Rad,1725274 Software,Software,Software SAMtools,Li

(10) SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neckCell reportsJuly 25, 2023Nigam N, Bernard B, Sevilla S, Kim S, Dar MS, Tsai D, Robbins Y, Burkitt K, Sievers C, Allen CT, et al.proteins","Chemicals, peptides, and recombinant proteins" Recombinant human interferon-β,R & D systems Inc.,Cat# 8499-IF-010/CF Critical commercial assays,Critical commercial assays,Critical commercial assays CUT&RUN Kit,Epicypher,Cat#

(11) Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1Life science allianceJune 1, 2023Nchioua R, Schundner A, Klute S, Koepke L, Hirschenberger M, Noettger S, Fois G, Zech F, Graf A, Krebs S, et al.post-seeding, the cells were stimulated with increasing amounts of IFNs (α2 [Cat#11101-2; R&D Systems], β [Cat#8499-IF-010/CF; R&D Systems], and γ [Cat#285-IF-100/CF; R&D Systems] using 5, 50, and 500 IU/ml or IFN-λ1 [Cat#1598-IL-025/CF;

(12) Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene inductioneLifeApril 24, 2023Spens AE, Sutliff NA, Bennett SR, Campbell AE, Tapscott SJ.11668019) according to the manufacturer’s protocol or were stimulated with 1000U IFNβ (R&D Systems, Cat# 8499-IF-010-CF) or 200 ng/ml IFNγ (R&D Systems, Cat# 285-IF-100-CF) by addition directly to cell culture medium. After

(13) A bacterial autotransporter impairs innate immune responses by targeting the transcription factor TFE3Nature communicationsApril 11, 2023Ta A, Ricci-Azevedo R, Vasudevan SO, Wright SS, Kumari P, Havira MS, Surendran Nair M, Rathinam VA, Vanaja SK.

(14) Electrically regulated cell‐based intervention for viral infectionsBioengineering & Translational MedicineMarch 1, 2023Sherri Newmyer, Marvin A. Ssemadaali, Harikrishnan Radhakrishnan, Harold S. Javitz, Parijat Bhatnagarand 1× penicillin–streptomycin solution). Recombinant human IFN‐β1a protein from R&D systems (Cat# 8499‐IF‐010/CF) was used as a control. 4.2 Generation of ES‐Biofactory (ES‐Biofactory➔Nluc; ES‐Biofactory➔IFN‐β) Jurkat

(15) Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisisNatureFebruary 1, 2023Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, et al.IFNβ. Chemical reagents The reagents were as follows: recombinant human IFN-beta protein: R&D Systems, 8499-IF-010/CF; poly(dA:dT): InvivoGen, tlrl-patn; poly(I:C): InvivoGen, tlrl-pic; 2′,3′-dideoxycytidine: Sigma-Aldrich,

(16) A fast-growing dengue virus mutant reveals a dual role of STING in response to infectionOpen biologyDecember 1, 2022Ng WC, Kwek SS, Sun B, Yousefi M, Ong EZ, Tan HC, Puschnik AS, Chan KR, Ooi YS, Ooi EE.

(17) Data supporting the roles of BAP1, STING, and IFN-β in ISGF3 activation in ccRCCData in briefDecember 1, 2022Langbein LE, Sementino E, Zhong Z, Jiang W, Li L, Testa JR, Yang H.

(18) Transcriptomic profiling implicates PAF1 in both active and repressive immune regulatory networksBMC genomicsNovember 30, 2022Kenaston MW, Pham OH, Petit MJ, Shah PS.

(19) STING-pathway modulation to enhance the immunogenicity of adenoviral-vectored vaccinesScientific reportsAugust 24, 2022Padron-Regalado E, Ulaszewska M, Douglas AD, Hill AVS, Spencer AJ.

(20) Phenotypic and Genetic Studies of the Viral Lineage Associated with the Recent Yellow Fever Outbreak in BrazilVirusesAugust 19, 2022Furtado ND, Gómez MM, de Mello IS, Fernandes DR, Bonaldo MC.

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Recombinant Human IFN-beta Protein, CF

IFN-beta Protein

IFN-beta Protein

Recombinant Human IFN-beta Protein, CF from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

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Recombinant Human IFN-beta Protein, CF from R&D Systems, a Bio-Techne Brand

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