Recombinant Human Sonic Hedgehog/Shh Protein, High Activity 8908-SH-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Sonic Hedgehog/Shh Protein, High Activity
CompanyR&D Systems, a Bio-Techne Brand
Price $420.00Supplier Page View Company Product Page
Catalog Number8908-SH-005
Size5 ug
FormatSupplied as a 0.2 µm filtered solution in MES, NaCl and CHAPS with BSA as a carrier protein
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 18-24 kDa, reducing conditions
Theoretical: 20 kDa
SpeciesHuman
Molecule NameSonic Hedgehog/Shh
NCBI Full Gene Namesonic hedgehog signaling molecule
NCBI Gene AliasesHPE3, SMMCI, HHG1, TPT, HLP3, TPTPS, ShhNC, MCOPCB5
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemHEK293-derived Recombinant Human Sonic Hedgehog/Shh Protein, High Activity
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -20 to -70 °C as supplied. 3 months, -20 to -70 °C under sterile conditions after opening

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Phosphorylation-induced SUMOylation promotes Ulk4 condensation at the ciliary tip to transduce Hedgehog signalJournal of cell scienceOctober 15, 2025Zhou M, Han Y, Jiang J.h to allow ciliation. The recombinant human Shh N-terminal fragment (Shh-N; 1 ng/ml; R&D Systems, #8908-SH-005) was then added to the same serum-free medium for 12 h or overnight. The cells were treated with TAK-981

(2) Two-way Dispatched function in Sonic hedgehog shedding and transfer to high-density lipoproteinseLifeSeptember 19, 2024Ehring K, Ehlers SF, Froese J, Gude F, Puschmann J, Grobe K.

(3) Diffusion barriers imposed by tissue topology shape Hedgehog morphogen gradientsProceedings of the National Academy of Sciences of the United States of AmericaSeptember 3, 2024Schlissel G, Meziane M, Narducci D, Hansen AS, Li P.

(4) Ulk4 promotes Shh signaling by regulating Stk36 ciliary localization and Gli2 phosphorylationElifeDecember 14, 2023Mengmeng Zhou, Yuhong Han, Jin Jiangfor 12 hr to allow ciliation. The recombinant human Shh N-terminal fragment (1 ng/ml; R&D Systems, #8908-SH-005) was then added to the same serum-free medium for 12 hr or overnight. Immunostaining, immunoprecipitation,

(5) Increasing Ciliary ARL13B Expression Drives Active and Inhibitor-Resistant Smoothened and GLI into Glioma Primary CiliaCellsSeptember 26, 2023Shi P, Tian J, Mallinger JC, Ling D, Deleyrolle LP, McIntyre JC, Caspary T, Breunig JJ, Sarkisian MR.

(6) Dose-dependent phosphorylation and activation of Hh pathway transcription factorsLife Science AllianceNovember 1, 2022Mengmeng Zhou, Yuhong Han, Bing Wang, Yong Suk Cho, Jin Jiangtreatment, cells were starved for 12 h (0.5% BCS), recombinant human Shh N-terminal fragment (1 ng/ml, #8908-SH-005; R&D Systems) or SAG (200 nm, Cat. no. 566660; Sigma-Aldrich) was added to the medium for 12 h or overnight. Immunostaining,

(7) Induced hepatic stem cells are suitable for human hepatocyte productioniScienceOctober 21, 2022Nakashima Y, Miyagi-Shiohira C, Saitoh I, Watanabe M, Matsushita M, Tsukahara M, Noguchi H.Corporation, Osaka, Japan), 200 ng/mL Recombinant Human Sonic Hedgehog/Shh Protein, High Activity (8908-SH-005: R&D SYSTEMS, Minneapolis, MN), 10 ng/mL bFGF (FGF2) (ReproCELL Inc., Kanagawa, Japan) in RPMI 1640

(8) Structural insights into proteolytic activation of the human Dispatched1 transporter for Hedgehog morphogen releaseNature communicationsNovember 29, 2021Li W, Wang L, Wierbowski BM, Lu M, Dong F, Liu W, Li S, Wang P, Salic A, Gong X.

(9) Forebrain Shh overexpression improves cognitive function and locomotor hyperactivity in an aneuploid mouse model of Down syndrome and its euploid littermatesActa neuropathologica communicationsAugust 16, 2021Gao FJ, Klinedinst D, Fernandez FX, Cheng B, Savonenko A, Devenney B, Li Y, Wu D, Pomper MG, Reeves RH.

(10) SLITRK5 is a negative regulator of hedgehog signaling in osteoblastsNature communicationsJuly 29, 2021Sun J, Shin DY, Eiseman M, Yallowitz AR, Li N, Lalani S, Li Z, Cung M, Bok S, Debnath S, et al.

(11) GLI2 but not GLI1/GLI3 plays a central role in the induction of malignant phenotype of gallbladder cancerOncology reportsMarch 1, 2021Ichimiya S, Onishi H, Nagao S, Koga S, Sakihama K, Nakayama K, Fujimura A, Oyama Y, Imaizumi A, Oda Y, et al.

(12) PAUPAR and PAX6 sequentially regulate human embryonic stem cell cortical differentiationNucleic acids researchFebruary 26, 2021Xu Y, Xi J, Wang G, Guo Z, Sun Q, Lu C, Ma L, Wu Y, Jia W, Zhu S, et al.

(13) Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium HomeostasisCell stem cellOctober 1, 2020Kim JW, Yin X, Jhaldiyal A, Khan MR, Martin I, Xie Z, Perez-Rosello T, Kumar M, Abalde-Atristain L, Xu J, et al.

(14) Nicotinamide restricts neural precursor proliferation to enhance catecholaminergic neuronal subtype differentiation from mouse embryonic stem cellsPloS oneJanuary 1, 2020Griffin SM, Pickard MR, Hawkins CP, Williams AC, Fricker RA.

(15) Structures of human Patched and its complex with native palmitoylated sonic hedgehogNatureAugust 1, 2018Qi X, Schmiege P, Coutavas E, Wang J, Li X.

(16) Roles of Ihh signaling in chondroprogenitor function in postnatal condylar cartilageMatrix biology : journal of the International Society for Matrix BiologyApril 1, 2018Kurio N, Saunders C, Bechtold TE, Salhab I, Nah HD, Sinha S, Billings PC, Pacifici M, Koyama E.

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Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Sonic Hedgehog/Shh High Activity Protein

Recombinant Human Sonic Hedgehog/Shh Protein, High Activity from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

Citations (16)

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Recombinant Human Sonic Hedgehog/Shh Protein, High Activity from R&D Systems, a Bio-Techne Brand

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