Recombinant Human Gas6 Protein, CF 885-GSB-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human Gas6 Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $516.00Supplier Page View Company Product Page
Catalog Number885-GSB-050
Size50 ug (also 500 ug)
FormatLyophilized from a 0.2 µm filtered solution in Tris, NaCl and Citrate
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecular WeightObserved: 70-85 kDa, reducing conditions
Theoretical: 70.5 kDa
SpeciesHuman
Molecule NameGas6
NCBI Full Gene Namegrowth arrest specific 6
NCBI Gene AliasesAXLLG, AXSF
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemNS0-derived Recombinant Human Gas6 Protein, CF
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Opposing role of phagocytic receptors MERTK and AXL in Progranulin deficient FTDCommun BiolJuly 1, 2025Claire Dudley Clelland, Li Fan, Rowan Saloner, Jon Iker Etchegaray, Chad Richard Altobelli, Sally Salomonsson, Alisha M. Maltos, Aradhana Sachdev, Jingjie Zhu, Se-In Lee, et al.BSA to prevent nonspecific binding. 150 RU of Fc-Mer or 140 RU of Fc-Axl was immobilized. Then, Gas6 (885-GSB-050, R&D Systems) or PGRN (AG-40A-0188Y-C050, AdipoGen) at the indicated concentration was injected at 20

(2) Roles of class III phosphatidylinositol 3-kinase, Vps34, in phagocytosis, autophagy, and endocytosis in retinal pigmented epitheliumiScienceMay 16, 2025Feng He, Ralph M. Nichols, Melina A. Agosto, Theodore G. WenselLab,017-000-121 BSA,Sigma,A9647 Fish gelatin,Sigma,G7765 MFG-E8,R & D Systems,2767-MF-050 Gas6,R & D Systems,885-GSB-050 Sodium cacodylate trihydrate,Sigma,C4945 Glutathione Sepharose High Performance GST-tagged protein purification

(3) Polychlorinated Biphenyl-126 Activates AXL/ERb/DNMT3A Axis to Drive Endometriosis ProgressionResearch squareMay 13, 2025Park Y, Sung N, Kim E, Jeong J, Sim J, Park MJ, Lydon J, Guan X, Han SJ.

(4) AXL-Mediated Drug Resistance in ALK-Rearranged NSCLC Enhanced by GAS6 From Macrophages and MMP11 Positive FibroblastsCancer scienceApril 1, 2025Utsumi T, Mizuta H, Seto Y, Uchibori K, Nishio M, Okamoto I, Katayama R.from Shanghai Biochempartner (Shanghai, China) and Biovision (Milpitas, CA, USA). In addition, human (885‐GSB‐050) and mouse (986‐GS‐025) recombinant Gas6 proteins were obtained from R&D Systems (Minneapolis, MN, USA). 2.4

(5) Non-canonical roles of CFH in retinal pigment epithelial cells revealed by dysfunctional rare CFH variantsStem cell reportsJanuary 14, 2025ten Brink SCA, Koolen L, Klaver CCW, Bakker RA, den Hollander AI, Almedawar S.

(6) Targeting Tyro3, Axl, and MerTK Receptor Tyrosine Kinases Significantly Sensitizes Triple-Negative Breast Cancer to CDK4/6 InhibitionCancersJune 18, 2024Demirsoy S, Tran H, Liu J, Li Y, Yang S, Aregawi D, Glantz MJ, Jacob NK, Walter V, Schell TD, et al.

(7) Regulation of Mertk Surface Expression via ADAM17 and γ-Secretase Proteolytic ProcessingInternational journal of molecular sciencesApril 17, 2024Lahey KC, Varsanyi C, Wang Z, Aquib A, Gadiyar V, Rodrigues AA, Pulica R, Desind S, Davra V, Calianese DC, et al.Gas6 reagents were analyzed for concentration via Western blotting using a Gas6 standard (R&D Systems, 885-GSB-050). Both Gas6-VK and Gas6-W were then diluted with SF DMEM to a stock concentration of 100 nM, with a

(8) Gas6-Axl Signaling Induces SRF/MRTF-A Gene Transcription via MICAL2GenesDecember 18, 2023Lundquist MR, Jaffrey SR.

(9) Mertk-expressing microglia influence oligodendrogenesis and myelin modelling in the CNSJournal of neuroinflammationNovember 6, 2023Nguyen LT, Aprico A, Nwoke E, Walsh AD, Blades F, Avneri R, Martin E, Zalc B, Kilpatrick TJ, Binder MD.

(10) CNK2 promotes cancer cell motility by mediating ARF6 activation downstream of AXL signallingNature communicationsJune 15, 2023Serwe G, Kachaner D, Gagnon J, Plutoni C, Lajoie D, Duramé E, Sahmi M, Garrido D, Lefrançois M, Arseneault G, et al.

(11) Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liverPLoS pathogensJune 1, 2023Tsugawa H, Ohki T, Tsubaki S, Tanaka R, Matsuzaki J, Suzuki H, Hozumi K.

(12) PRAME Is a Novel Target of Tumor-Intrinsic Gas6/Axl Activation and Promotes Cancer Cell Invasion in Hepatocellular CarcinomaCancersApril 22, 2023Hedrich V, Breitenecker K, Ortmayr G, Pupp F, Huber H, Chen D, Sahoo S, Jolly MK, Mikulits W.

(13) Targeting AXL Using the AVB-500 Soluble Receptor and through Genetic Knockdown Inhibits Bile Duct Cancer Growth and MetastasisCancersMarch 21, 2023Kim J, Nam G, Shin YK, Vilaplana-Lopera N, Jeung HC, Moon EJ, Lee IJ.and then treated with 10 μg/mL or 100 μg/mL AVB-500 with the addition of 50 ng/mL GAS6 (R&D systems #885-GSB-050) for 24 h. 2.4. Growth Curve Analysis Wild-type HUCCT1 and SNU1196 cells, and those infected with

(14) AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancerBMC cancerApril 23, 2022Iida M, McDaniel NK, Kostecki KL, Welke NB, Kranjac CA, Liu P, Longhurst C, Bruce JY, Hong S, Salgia R, et al.

(15) High Glucose Impairs Expression and Activation of MerTK in ARPE-19 CellsInternational journal of molecular sciencesJanuary 20, 2022Puddu A, Ravera S, Panfoli I, Bertola N, Maggi D.

(16) Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cellsOncology lettersNovember 1, 2021Chang H, An R, Li X, Lang X, Feng J, Lv M.

(17) Corosolic Acid Attenuates the Invasiveness of Glioblastoma Cells by Promoting CHIP-Mediated AXL Degradation and Inhibiting GAS6/AXL/JAK AxisCellsOctober 28, 2021Sun LW, Kao SH, Yang SF, Jhang SW, Lin YC, Chen CM, Hsieh YH.

(18) Quantitative Tyrosine Phosphoproteome Profiling of AXL Receptor Tyrosine Kinase Signaling NetworkCancersAugust 23, 2021Wu X, Wang L, Pearson NA, Renuse S, Cheng R, Liang Y, Mun DG, Madugundu AK, Xu Y, Gill PS, et al.

(19) KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathwayCell death and differentiationApril 1, 2021Du W, Zhu J, Zeng Y, Liu T, Zhang Y, Cai T, Fu Y, Zhang W, Zhang R, Liu Z, et al.

(20) ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXLNature communicationsNovember 17, 2020Pietrobono S, Anichini G, Sala C, Manetti F, Almada LL, Pepe S, Carr RM, Paradise BD, Sarkaria JN, Davila JI, et al.serum-starved for 16 h and stimulated for 1 hr with 250 ng/ml of human recombinant GAS6 (R&D Systems, 885-GSB-050) on ice. Cells were then crosslinked with 3 mM BS3 (Sigma-Aldrich, Cat.no. 82436-77-9) for 20 min on

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Recombinant Human Gas6 Protein, CF

Gas6 Protein

Gas6 Protein

Recombinant Human Gas6 Protein, CF from R&D Systems, a Bio-Techne Brand

R&D Systems, a Bio-Techne Brand

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Recombinant Human Gas6 Protein, CF from R&D Systems, a Bio-Techne Brand

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