Recombinant Human IL-15 Protein 247-ILB-005 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant Human IL-15 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $311.00Supplier Page View Company Product Page
Catalog Number247-ILB-005
Size5 ug (also 25 ug)
FormatLyophilized from a 0.2 µm filtered solution in PBS with BSA as a carrier protein
Purity>97%, by SDS-PAGE with silver staining
Molecular WeightObserved: 10 kDa, under reducing conditions.
Theoretical: 12.5 kDa
SpeciesHuman
Molecule NameIL-15
NCBI Full Gene Nameinterleukin 15
NCBI Gene AliasesIL-15
ApplicationsBioactivity
Conjugate/TagUnconjugated
Source/Expression SystemE. coli-derived Recombinant Human IL-15 Protein
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Toggling of NKG2A expression drives functional specialization of iPSC-derived CAR NK cellsbioRxiv : the preprint server for biologyAugust 23, 2025Kanaya M, Philippon C, Netskar H, Saetersmoen ML, Cieslar-Pobuda A, Torralba-Raga L, Casoni GP, Hammer Q, Vincenti M, Wiiger MT, et al.

(2) Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1EMBO molecular medicineJuly 1, 2025Sánchez-Cerrillo I, Agudo-Lera M, Popova O, Tsukalov I, Calvet-Mirabent M, de Los Santos I, García-Fraile L, Fuentes P, Delgado-Arévalo C, Alcain J, et al.

(3) A thermoplastic chip for 2D and 3D correlative assays combining screening and high-resolution imaging of immune cell responsesCell Reports MethodsJanuary 27, 2025Hanna van Ooijen, Quentin Verron, Hanqing Zhang, Patrick A. Sandoz, Thomas W. Frisk, Valentina Carannante, Karl Olofsson, Arnika K. Wagner, Niklas Sandström, Björn Önfeltsulfate,Sigma-Aldrich,Cat#P3369 Puromycin,ThermoFisher Scientific,Cat#A1113803 Interleukin-2,PeproTech,Cat#200-02 Interleukin-15,R&D Systems,Cat#247-ILB-005 D-Glucose,Sigma-Aldrich,Cat#D8375 D-Mannitol,Sigma-Aldrich,Cat#M4125 L-glutamine,Sigma-Aldrich,Cat#G7513 Lactic

(4) Antigen-Specific T Cell Receptor Discovery for Treating Progressive Multifocal LeukoencephalopathybioRxiv : the preprint server for biologyNovember 4, 2024Gupta S, Martinov T, Thelen A, Sunahara M, Mureli S, Vazquez A, Gerdts J, Dandekar R, Cortese I, Fouassier C, et al.

(5) Dihydrotestosterone Enhances MICA-Mediated Immune Responses to Epstein–Barr Virus-Associated Gastric CarcinomaCancers (Basel)September 21, 2024Donghyun Seo, Hyeji Byun, Miyeon Cho, Sun Hee Lee, Sohyun Youn, Junho Lee, Inuk Jung, Hyosun Cho, Hyojeung Kangpenicillin–streptomycin, IL-2 (20 IU/mL), IL-7 (20 ng/mL, 207-IL-010, R&D Systems), and IL-15 (20 ng/mL, 247-ILB-005, R&D Systems) for seven days. The study protocol was approved by Kyungpook National University (Daegu,

(6) IOS-1002, a Stabilized HLA-B57 Open Format, Exerts Potent Anti-Tumor ActivityCancersAugust 21, 2024Rafiei A, Gualandi M, Yang CL, Woods R, Kumar A, Brunner K, Sigrist J, Ebersbach H, Coats S, Renner C, et al.

(7) A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesisCell death and differentiationAugust 1, 2024Cheng YC, Acedera JD, Li YJ, Shieh SY.(200-LA-002), IL10 (217-IL-005), CCL4 (271-BME-010), CCL20 (360-MP-025), FGF7 (251-KG-010), and IL15 (247-ILB-005) from R&D Systems, and EGF (E4269) from Sigma-Aldrich. Cytokine antibody array analysis CM was prepared

(8) Generation and optimization of off-the-shelf immunotherapeutics targeting TCR-Vβ2+ T cell malignancyNature communicationsJanuary 15, 2024Ren J, Liao X, Lewis JM, Chang J, Qu R, Carlson KR, Foss F, Girardi M.

(9) Immunoglobulin-like transcript 2 as an impaired anti-tumor cytotoxicity marker of natural killer cells in patients with hepatocellular carcinomaFrontiers in immunologyJanuary 1, 2024Sakata T, Yoshio S, Yamazoe T, Mori T, Kakazu E, Aoki Y, Aoyanagi N, Okamoto T, Ito T, Toyoda H, et al.cells and 5×104 magnetic cell-sorted NK cells from HVs were conducted with recombinant IL-15 1 ng/mL (247-ILB-005; R&D Systems, Minneapolis, MN) in a 24-well plate for 72 h. For co-cultures using transwell inserts,

(10) IL-10-Engineered Dendritic Cells Modulate Allogeneic CD8(+) T Cell ResponsesInternational journal of molecular sciencesMay 23, 2023Fortunato M, Amodio G, Gregori S.

(11) Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironmentNature CancerMarch 16, 2023Sayali Onkar, Jian Cui, Jian Zou, Carly Cardello, Anthony R. Cillo, Mostofa Rafid Uddin, April Sagan, Marion Joy, Hatice U. Osmanbeyoglu, Katherine L. Pogue-Geile, et al.for flow cytometric analysis Similar protocol was used to test the effect of IL-15 (R&D Systems, cat#247-ILB-005) and IL-33 (R&D Systems, cat# 3625-IL-010) on monocyte polarization. Media containing M-CSF (50ng/ml)+

(12) Identification of T Cell Receptors Targeting a Neoantigen Derived from Recurrently Mutated FGFR3CancersFebruary 6, 2023Tate T, Matsumoto S, Nemoto K, Leisegang M, Nagayama S, Obama K, Nakamura Y, Kiyotani K.

(13) Adipose tissue from subjects with type 2 diabetes exhibits impaired capillary formation in response to GROα: involvement of MMPs-2 and -9AdipocyteDecember 31, 2022Yifat Amir Levy, Theodore P Ciaraldi, Sunder R. Mudaliar, Susan A. Phillips, Robert R. Henry(Life-Technologies/Gibco,). Explants were treated with rIL8 (#208-IL-010/CF), rGROα (#275–GR–010), and rIL15 (#247-ILB-005) (all recombinant proteins are human low-endotoxin from R&D Systems). Media and treatments were replaced

(14) DLL4 and VCAM1 enhance the emergence of T cell-competent hematopoietic progenitors from human pluripotent stem cellsScience advancesAugust 26, 2022Michaels YS, Edgar JM, Major MC, Castle EL, Zimmerman C, Yin T, Hagner A, Lau C, Hsu HH, Ibañez-Rios MI, et al.

(15) Detection of early seeding of Richter transformation in chronic lymphocytic leukemiaNature medicineAugust 1, 2022Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, et al.

(16) Natural killer cell-mediated ADCC in SARS-CoV-2-infected individuals and vaccine recipientsEuropean journal of immunologyAugust 1, 2022Hagemann K, Riecken K, Jung JM, Hildebrandt H, Menzel S, Bunders MJ, Fehse B, Koch-Nolte F, Heinrich F, Peine S, et al.

(17) Novel IL-15 dendritic cells have a potent immunomodulatory effect in immunotherapy of multiple myelomaTranslational oncologyJune 1, 2022Chu TH, Vo MC, Lakshmi TJ, Ahn SY, Kim M, Song GY, Yang DH, Ahn JS, Kim HJ, Jung SH, et al.

(18) The Thermal Dose of Photothermal Therapy Generates Differential Immunogenicity in Human Neuroblastoma CellsCancersMarch 11, 2022Sekhri P, Ledezma DK, Shukla A, Sweeney EE, Fernandes R.

(19) Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphomaNature communicationsSeptember 22, 2021Liang HC, Costanza M, Prutsch N, Zimmerman MW, Gurnhofer E, Montes-Mojarro IA, Abraham BJ, Prokoph N, Stoiber S, Tangermann S, et al.

(20) Deciphering the biology of KIR2DL3⁺ T lymphocytes that are associated to relapse in haploidentical HSCTScientific reportsAugust 4, 2021David G, Willem C, Legrand N, Djaoud Z, Mérieau P, Walencik A, Guillaume T, Gagne K, Chevallier P, Retière C.

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IL-15 Protein

IL-15 Protein

IL-15 Protein

Recombinant Human IL-15 Protein from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

Citations (177)

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Recombinant Human IL-15 Protein from R&D Systems, a Bio-Techne Brand

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