Fig 1: Cell model of AD-related Tau pathology: effects of oTau on primary mouse HNs. (A) Schematic representation of the protocol. (B) Elongation analysis of primary mouse HNs treated with 50 nM oTau versus control condition. Violin plot, data are expressed as median (dashed line) and 25–75 percentiles (dotted lines). n = 120, from four replicates. Mann–Whitney test for unpaired data, two-tailed. **** = p < 0.0001. (C) Analysis of the percentage of pyknotic nuclei of primary mouse HNs treated with 50 nM oTau versus control condition. Violin plot, data are expressed as median (dashed line) and 25–75 percentiles (dotted lines). n = 16, from four replicates. N > 2000 of total nuclei for each replicate. Unpaired t-test, two-tailed. ns, not significant.