Fig 1: (A) Representative images of IHC staining of IGF-1 and IGF-1r in the control group, the C. acnes group, the C. acnes +Phage group, the C. acnes +Antibiotics group, and the phage group at 400 × magnification. (B) IHC scores of IGF-1 in IHC staining images (C) Measurement of IHC scores of IGF-1r in IHC staining images. (D) The protein bands of IGF-1, IGF-1r, and GAPDH in the control group, the C. acnes group, the C. acnes +Phage group, the C. acnes +Antibiotics group and the phage group are shown by the Western blot method. (E) The expression levels of IGF-1 protein were measured by the WB method. GAPDH served as the internal control. (F) The expression levels of IGF-1r protein were measured by the WB method. GAPDH served as the internal control. (G) Relative expression of mRNA of IGF-1 in the control group, the C. acnes group, the C. acnes +Phage group, the C. acnes +Antibiotics group, and the phage group detected by the qRT-PCR method. GAPDH served as the internal control. Ns, no significance; * P < 0.05; ** P < 0.01.