CD40 Ligand/TNFSF5 Protein 8230-CL-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCD40 Ligand/TNFSF5 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $449.00Supplier Page View Company Product Page
Catalog Number8230-CL-050
FormatLyophilized from a 0.2 µm filtered solution in PBS and NaCl with BSA as a carrier protein
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
Purity>95%, by SDS-PAGE with silver staining
NCBI Gene AliasesLy62, Tnfsf5, IMD3, HIGM1, CD40-L, gp39, Cd40l, Tnlg8b, CD40L, CD154, TNFSF5, hCD40L, IGM, Ly-62, T-BAM, TRAP
NCBI Full Gene NameCD40 ligand
Source/Expression SystemCHO-derived Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein
Molecule NameCD40 Ligand/TNFSF5
SpeciesMouse
Size50 ug

Specifications/Features

Available conjugates: Sizes Available: 50 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreadingImmunityMarch 10, 2026Yu Yan (颜雨), Xuesong Wang (王雪松), Zhenfei Xie, Daniel L. V. Bader, Ryan H. Lim, Krystal M. Ma, Christopher A. Cottrell, Jon M. Steichen, Liling Xu, Paula M. Villavicencio, et al.,R and D systems,Cat#: 405-ML-025 Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag) Protein,R and D systems,Cat#: 8230-CL-050 RPMI 1640 Medium,Thermo Fisher Scientific,Cat#: 11875119 Fetal Bovine Serum,MilliporeSigma,Cat#: F4135-500ML HEPES,Thermo Fisher Scientific

(2) Type I interferons induce an epigenetically distinct memory B cell subset in chronic viral infectionImmunityMay 14, 2024Cooper L, Xu H, Polmear J, Kealy L, Szeto C, Pang ES, Gupta M, Kirn A, Taylor JJ, Jackson KJL, et al.,Thermo Fisher Scientific,Cat # AM2542 AMPure XP Beads,Beckman Coulter,Cat # A63881 CD40L,R&D Systems,Cat # 8230-CL-050 Goat anti-mouse F(ab’)2 Ig,Southern Biotech,Cat # 1012–01 IL-21,STEMCELL Technologies,Cat # 78116.1 Critical

(3) Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cellsNature communicationsApril 4, 2022Franchina DG, Kurniawan H, Grusdat M, Binsfeld C, Guerra L, Bonetti L, Soriano-Baguet L, Ewen A, Kobayashi T, Farinelle S, et al.activated with 5 µg/mL anti-IgM (Jackson Immunoresearch 715-006-020), 50 ng/mL CD40 ligand (Bio-techne 8230-CL-050) and 10 ng/mL IL-4 (Miltenyi Biotec 130-097-757). Reduced GSH was purchased from Sigma (G4251). MZB

(4) Targeting BMI-1 in B cells restores effective humoral immune responses and controls chronic viral infectionNature immunologyJanuary 1, 2022Di Pietro A, Polmear J, Cooper L, Damelang T, Hussain T, Hailes L, O'Donnell K, Udupa V, Mi T, Preston S, et al.

(5) The Histone Methyltransferase DOT1L Is Essential for Humoral Immune ResponsesCell reportsDecember 15, 2020Kealy L, Di Pietro A, Hailes L, Scheer S, Dalit L, Groom JR, Zaph C, Good-Jacobson KL.

(6) Missing-in-Metastasis/Metastasis Suppressor 1 Regulates B Cell Receptor Signaling, B Cell Metabolic Potential, and T Cell-Independent Immune ResponsesFrontiers in immunologyJanuary 1, 2020Sarapulov AV, Petrov P, Hernández-Pérez S, Šuštar V, Kuokkanen E, Cords L, Samuel RVM, Vainio M, Fritzsche M, Carrasco YR, et al.Metabolism" CpG ODN 1826,tlrl-1826,Invivogen,Metabolism "CD40L, Recombinant Mouse CD40 Ligand/TNFSF5 (HA-tag)",8230-CL-050,R&D Systems,CSR "IL-4, Recombinant Mouse IL-4",404-ML-010,R&D Systems,"CSR, Metabolism" "IFNγ, Recombinant

(7) Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic CellsJournal of immunology (Baltimore, Md. : 1950)November 15, 2018Abdi K, Laky K, Padhan K, Petrovas C, Skinner J, Kabat J, Dorward DW, Brzostowski J, Long EO, Trinchieri G, et al.

(8) Mining the Plasma Cell Transcriptome for Novel Cell Surface ProteinsInternational journal of molecular sciencesJuly 24, 2018Trezise S, Karnowski A, Fedele PL, Mithraprabhu S, Liao Y, D'Costa K, Kueh AJ, Hardy MP, Owczarek CM, Herold MJ, et al.

(9) Regulation of the DNA Repair Complex during Somatic Hypermutation and Class-Switch RecombinationJournal of immunology (Baltimore, Md. : 1950)June 15, 2018Kumar A, Priya A, Ahmed T, Grundström C, Negi N, Grundström T.

(10) B cell activation and plasma cell differentiation are inhibited by de novo DNA methylationNature communicationsMay 15, 2018Barwick BG, Scharer CD, Martinez RJ, Price MJ, Wein AN, Haines RR, Bally APR, Kohlmeier JE, Boss JM.

(11) Plasma cell differentiation is controlled by multiple cell division-coupled epigenetic programsNature communicationsApril 27, 2018Scharer CD, Barwick BG, Guo M, Bally APR, Boss JM.

(12) Zinc finger-IRF composite elements bound by Ikaros/IRF4 complexes function as gene repression in plasma cellBlood advancesApril 24, 2018Ochiai K, Kondo H, Okamura Y, Shima H, Kurokochi Y, Kimura K, Funayama R, Nagashima T, Nakayama K, Yui K, et al.

(13) T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell FateImmunityApril 17, 2018Ise W, Fujii K, Shiroguchi K, Ito A, Kometani K, Takeda K, Kawakami E, Yamashita K, Suzuki K, Okada T, et al.

(14) Bach2 Promotes B Cell Receptor-Induced Proliferation of B Lymphocytes and Represses Cyclin-Dependent Kinase InhibitorsJournal of immunology (Baltimore, Md. : 1950)April 15, 2018Miura Y, Morooka M, Sax N, Roychoudhuri R, Itoh-Nakadai A, Brydun A, Funayama R, Nakayama K, Satomi S, Matsumoto M, et al.

(15) Identification and characterisation of the CD40-ligand of Sigmodon hispidusPloS oneJanuary 1, 2018Russell MS, Muralidharan A, Larocque L, Cao J, Deschambault Y, Varga J, Thulasi Raman SN, Li X.

(16) Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritisTheranosticsJanuary 1, 2018Cosenza S, Toupet K, Maumus M, Luz-Crawford P, Blanc-Brude O, Jorgensen C, Noël D.

(17) The Small Rho GTPase TC10 Modulates B Cell Immune ResponsesJournal of immunology (Baltimore, Md. : 1950)September 1, 2017Burbage M, Keppler SJ, Montaner B, Mattila PK, Batista FD.

(18) Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivoScientific reportsJuly 11, 2017Lee BC, Lee SG, Choo MK, Kim JH, Lee HM, Kim S, Fomenko DE, Kim HY, Park JM, Gladyshev VN.

(19) Regulated localization of an AID complex with E2A, PAX5 and IRF4 at the Igh locusMolecular immunologyDecember 1, 2016Hauser J, Grundström C, Kumar R, Grundström T.

(20) TLR3-Induced Maturation of Murine Dendritic Cells Regulates CTL Responses by Modulating PD-L1 TraffickingPloS oneJanuary 1, 2016Varthaman A, Moreau HD, Maurin M, Benaroch P.

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CD40 Ligand/TNFSF5 Protein

CD40 Ligand/TNFSF5 Protein from R&D Systems, a Bio-Techne Brand

Description

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (24)

Reviews

CD40 Ligand/TNFSF5 Protein from R&D Systems, a Bio-Techne Brand

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