TGF-beta 1 Protein 7754-BH-005/CF from R&D Systems, a Bio-Techne Brand

Product Specs
ItemTGF-beta 1 Protein
CompanyR&D Systems, a Bio-Techne Brand
Price Pricing Info Supplier Page View Company Product Page
Catalog Number7754-BH-005/CF
Quantity5 ug (also 25 ug, 100 ug, 500 ug, 1000 ug)
Molecule NameTGF-beta 1
SpeciesHuman
Source/Expression SystemHEK293-derived Recombinant Human TGF-beta 1 (Human Cell-expressed)
NCBI Full Gene Nametransforming growth factor beta 1
NCBI Gene AliasesTGF-beta1, TGFB, DPD1, TGFbeta, CED, IBDIMDE, LAP
FormatLyophilized from a 0.2 µm filtered solution in Acetonitrile and TFA
Purity>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Molecular WeightObserved: 11 kDa, reducing conditions
Theoretical: 12.8 kDa (monomer)
Brand/TrademarkR&D Systems, a Bio-Techne Brand
ApplicationsBioactivity
Conjugate/TagUnconjugated
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Unconjugated

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Epidermal growth factor receptor activation is essential for kidney fibrosis developmentNature CommunicationsNovember 14, 2023Shirong Cao, Yu Pan, Andrew S. Terker, Juan Pablo Arroyo Ornelas, Yinqiu Wang, Jiaqi Tang, Aolei Niu, Sarah Abu Kar, Mengdi Jiang, Wentian Luo, et al.Sigma-Aldrich), HB-EGF plus an EGFR inhibitor (AG1478, 10 μM, LC laboratories) or TGF-β (5 ng/ml, cat# 7754BH005CF, R&D Systems™) in the presence or absence of 5% serum for 16 h. Cells in the upper chamber were removed

(2) Minoxidil weakens newly synthesized collagen in fibrotic synoviocytes from osteoarthritis patientsJ Exp OrthopAugust 21, 2023Stefan Sarkovich, Peter P. Issa, Andrew Longanecker, Davis Martin, Kaitlyn Redondo, Patrick McTernan, Jennifer Simkin, Luis Marrerocontrol. Stimulation and treatment of cultured FSCs Carrier-free, recombinant TGFβ1 (R&D Systems; #7754-BH-005/CF) was dissolved in 10 mM citric acid to a 50,000 ng/ml stock for dilution in SGM to 1, 2, or 4 ng/mL

(3) Conserved stromal-immune cell circuits secure B cell homeostasis and functionNature immunologyJuly 1, 2023Lütge M, De Martin A, Gil-Cruz C, Perez-Shibayama C, Stanossek Y, Onder L, Cheng HW, Kurz L, Cadosch N, Soneson C, et al.

(4) Poricoic acid A suppresses renal fibroblast activation and interstitial fibrosis in UUO rats via upregulating Sirt3 and promoting β-catenin K49 deacetylationActa pharmacologica SinicaMay 1, 2023Chen DQ, Chen L, Guo Y, Wu XQ, Zhao TT, Zhao HL, Zhang HJ, Yan MH, Zhang GQ, Li P.

(5) Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasionJournal of Clinical InvestigationApril 17, 2023Yea Ji Jeong, Hildur Knutsdottir, Fatemeh Shojaeian, Michael G. Lerner, Maria F. Wissler, Elodie Henriet, Tammy Ng, Shalini Datta, Bernat Navarro-Serer, Peter Chianchiano, et al.(Sigma-Aldrich, PF024; 10 ng/mL), SDF-1 (CXCL12) (Peprotech, 300-28B; 100 ng/mL), and TGF-β1 (Biotechne, 7754-BH-005/CF; 5 ng/mL). The control organoids were given feeding media only. All PDAC organoids were imaged 72 hours

(6) DRAK2 contributes to type 1 diabetes by negatively regulating IL-2 sensitivity to alter regulatory T cell developmentCell reportsFebruary 28, 2023Mandarano AH, Harris TL, Creasy BM, Wehenkel M, Duggar M, Wilander BA, Mishra A, Crawford JC, Mullen SA, Williams KM, et al.

(7) TGF-β is elevated in hyperuricemic individuals and mediates urate-induced hyperinflammatory phenotype in human mononuclear cellsArthritis research & therapyFebruary 27, 2023Klück V, Cabău G, Mies L, Bukkems F, van Emst L, Bakker R, van Caam A, HINT consortium, Crişan TO, Joosten LAB.

(8) Nsun2 coupling with RoRγt shapes the fate of Th17 cells and promotes colitisNature communicationsFebruary 16, 2023Yang WL, Qiu W, Zhang T, Xu K, Gu ZJ, Zhou Y, Xu HJ, Yang ZZ, Shen B, Zhao YL, et al.

(9) 5-FU-miR-15a Inhibits Activation of Pancreatic Stellate Cells by Reducing YAP1 and BCL-2 Levels In VitroInternational journal of molecular sciencesFebruary 16, 2023Almanzar VMD, Shah K, LaComb JF, Mojumdar A, Patel HR, Cheung J, Tang M, Ju J, Bialkowska AB.

(10) ANGPTL4 stabilizes atherosclerotic plaques and modulates the phenotypic transition of vascular smooth muscle cells through KLF4 downregulationExperimental & molecular medicineFebruary 1, 2023Cho DI, Ahn MJ, Cho HH, Cho M, Jun JH, Kang BG, Lim SY, Yoo SJ, Kim MR, Kim HS, et al.

(11) xcore: an R package for inference of gene expression regulatorsBMC bioinformaticsJanuary 11, 2023Migdał M, Arakawa T, Takizawa S, Furuno M, Suzuki H, Arner E, Winata CL, Kaczkowski B.

(12) LINC01146/F11R facilitates growth and metastasis of prostate cancer under the regulation of TGF-βThe Journal of steroid biochemistry and molecular biologyJanuary 1, 2023Guo X, Gu Y, Guo C, Pei L, Hao C.

(13) TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle developmenteLifeDecember 21, 2022Feng J, Han X, Yuan Y, Cho CK, Janečková E, Guo T, Pareek S, Rahman MS, Zheng B, Bi J, et al.

(14) Nanoparticle endothelial delivery of PGC-1α attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodelingRedox biologyDecember 1, 2022Cai D, Chen SY.

(15) SMAD3 mutation in LDS3 causes bone fragility by impairing the TGF-β pathway and enhancing osteoclastogenesisBone reportsDecember 1, 2022El-Gazzar A, Kang H, Fratzl-Zelman N, Webb E, Barnes AM, Jovanovic M, Mehta SG, Datta V, Saraff V, Dale RK, et al.

(16) Airway basal cells show a dedifferentiated KRT17(high)Phenotype and promote fibrosis in idiopathic pulmonary fibrosisNature communicationsSeptember 26, 2022Jaeger B, Schupp JC, Plappert L, Terwolbeck O, Artysh N, Kayser G, Engelhard P, Adams TS, Zweigerdt R, Kempf H, et al.control, for cFn and Type I Collagen, fibroblasts were treated with 10 ng/ml TGF-beta (R&D Systems, #7754-BH-005/CF) for 48 h. Afterward, the cells were directly lysed in 5 × Laemmli buffer containing 10% β-mercaptoethanol

(17) IL-17A in Human Liver: Significant Source of Inflammation and Trigger of Liver Fibrosis InitiationInternational journal of molecular sciencesAugust 29, 2022Kartasheva-Ebertz D, Gaston J, Lair-Mehiri L, Mottez E, Buivan TP, Massault PP, Scatton O, Gaujoux S, Vaillant JC, Pol S, et al.

(18) Sphingosine kinase 1 mediates sexual dimorphism in fibrosis in a mouse model of NASHMolecular metabolismAugust 1, 2022Montefusco D, Jamil M, Maczis MA, Schroeder W, Levi M, Ranjit S, Allegood J, Bandyopadhyay D, Retnam R, Spiegel S, et al.

(19) Modified Shenlingbaizhu Decoction represses the pluripotency of colorectal cancer stem cells by inhibiting TGF-β mediated EMT programPhytomedicine : international journal of phytotherapy and phytopharmacologyAugust 1, 2022Dai Y, Wang H, Sun R, Diao J, Ma Y, Shao M, Xu Y, Zhang Q, Gao Z, Zeng Z, et al.

(20) Kynurenine metabolites predict survival in pulmonary arterial hypertension: A role for IL-6/IL-6RαScientific reportsJuly 19, 2022Cai Z, Tian S, Klein T, Tu L, Geenen LW, Koudstaal T, van den Bosch AE, de Rijke YB, Reiss IKM, Boersma E, et al.was 20 ng/mL for TNF-α (210-TA-020/CF), IL-6 (7270-IL-025/CF), IL-6/IL-6Rα (8954-SR/CF) and TGF-β1 (7754-BH-005/CF). MVECs were exposed to cytokines or hypoxia in basal medium with 0.5% FBS for 24 h prior to collection

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TGF-beta 1 Protein

TGF-beta 1 Protein

TGF-beta 1 Protein

TGF-beta 1 Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (57)

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TGF-beta 1 Protein from R&D Systems, a Bio-Techne Brand

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