Fig 2: 2D and 3D interaction diagrams of compound P5 with A,C,E) MDM2 and B,D,F) MDMX, illustrating hydrogen bonding, π–π stacking, and hydrophobic interactions. (E) and (F) display hydrophobic interaction surfaces.

Fig 3: Surface plasmon resonance analysis of A,B) MDM2 and C,D) MDMX binding by (B,D) P5 and the (A,C) reference compound Nutlin‐3, with sensorgram traces represented as dotted lines and fitted curves as solid lines.