ROS1 (G2032R), Active AAA73930 from AAA Biotech, LLC

Description

Recombinant human ROS1 (G2032R)(1881-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_002944.
ROS1 is a proto-oncogene and member of the sevenless subfamily of tyrosine kinase insulin receptor genes. ROS1 is highly-expressed in a variety of tumor cell lines and functions as a growth or differentiation factor receptor. The FIG gene can fuse with the ROS1 gene in glioblastoma cell lines (1). The resulting ROS1/FIG fusion protein is a constitutively activated tyrosine kinase. Direct interaction of ROS1 and the phosphatase SHP-1 can lead to efficient downregulation of ROS1-mediated signaling (2). Binding sites in the ROS1 cytoplasmic domain display high affinity binding to the SHP-1 N-terminal SH2 domain

Product Specs
ItemROS1 (G2032R), Active
CompanyAAA Biotech, LLC
Price $445.00Supplier Page View Company Product Page
Catalog NumberAAA73930
StorageStore product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles
TypeRecombinant Protein
Size0.05 mg, 5x0.5 mg, 4x0.5 mg, 3x0.5 mg, 2x0.5 mg, 0.01 mg, 0.5 mg
FormatRecombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol
ApplicationsWB (Western Blot), Kinase Assay
HostSf9 insect cells
Molecular Weight~82kDa
NCBI Full Gene NameROS proto-oncogene 1, receptor tyrosine kinase
NCBI Gene AliasesMCF3, ROS, c-ros-1
Molecule NameROS1