Fig 1: nuclear hormone receptor (NR) panel results.(A) Concentration-response for recruitment of coregulator D22 to RXRα (dotted lines) and RXRβ (solid line), determined by coregulator TR-FRET (CRT) assay, showing mean and SD, normalized to SR11237 as a full agonist. (B) Concentration-response for recruitment of coregulator SRC2 to farnesoid X receptor (FXR) determined by CRT assay, showing mean and SD, normalized to Obeticholic acid (OCA) as a full agonist. (C) Concentration-response for recruitment of coregulator C33 to PPARδ determined by CRT assay, showing mean and SD, normalized to GW501516 as a full agonist. (D) Concentration-response for recruitment of coregulator D22 to RARα (dotted lines) and recruitment of coregulator SRC2-2 RARβ (solid line), determined by CRT assay, showing mean and SD, normalized to TTNPB as a full agonist. (E) Concentration-response for recruitment of coregulator SRC1-4 to pregnane X receptor PXR determined by CRT assay, showing mean and SD, normalized to T0901317(T0) as a full agonist. Figure 2—figure supplement 1—source data 1.Summary of nuclear hormone receptor (NR) panel parameters. Figure 2—figure supplement 1—source data 2.Coregulator peptide sequences.