Fig 1: GLP-1(7–37) and GLP-1RA sequences. Amino acid sequences for GLP-1(7–37) (PDB entry 3IOL, chain B), exenatide (PDB entry 7MLL, chain A), dulaglutide (with a modified IgG4 Fc domain, DrugBank entry DB09045), liraglutide (PDB entry 4APD, chain A), semaglutide (PDB entry 7KI0, chain E), and tirzepatide (PDB entry 7RGP, chain F). Differences in GLP-1RA amino acid sequences relative to GLP-1 are indicated in blue. Aib, 2-aminoisobutyric acid. The lysine residues of liraglutide, semaglutide, and tirzepatide that are modified with linkers are highlighted in red. Expanded structures are shown in Figure S1.
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