A 779 HY-P0216 from MedChemExpress

Product Specs
ItemA 779
CompanyMedChemExpress
Price $30.00Supplier Page View Company Product Page
Catalog NumberHY-P0216
FormulaC39H60N12O11
TypeChemical
ApplicationsBioactivity, Structure and function analysis, ELISA, SDS-PAGE, Western blotting
Size1 mg
Molecule NameA 779
Research AreaEndocrinology; Cardiovascular Disease
Molecular Weight872.97
Purity99.12%

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(1) Angiotensin-(1-7) Alleviates Isoproterenol-Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin II Type 2 ReceptorActa Physiol (Oxf)March 26, 2026Xiaomei Wang, Fei Guo, Xiaoqian Wang, Yu Guo, Siyao Fan, Lan Hong, Honghua Jinμg/kg/day (MCE, HY‐12403, USA; in distilled water); ISO + Ang‐(1–7) + A‐779: A‐7791148 μg/kg/day (MCE, HY‐P0216, USA); ISO + Ang‐(1–7) + PD123319: PD123319 5 mg/kg/day (MCE, HY‐10259A, USA); ISO + Ang‐(1–7) + PD123319

(2) Geraniin Alleviates Mouse Laser-Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell ACE2/Ang-(1-7)/MasR/IL-10 PathwayJournal of cellular and molecular medicineDecember 1, 2024Lu H, Cai Q, Li L, Gu J, Zhang Y, Sun H, Su H, Song L.(1 μM for 24 h) (50–194‐6749, Thermo Fisher Scientific), the MasR antagonist A‐779 (1 μM for 24 h) (HY‐P0216, MedChemExpress), or neutralising anti‐IL‐10 antibody (2 μg for 24 h) (MAB217, R&D Systems, USA). 1.2

(3) ACE2 alleviates sepsis-induced cardiomyopathy through inhibiting M1 macrophage via NF-κB/STAT1 signalsCell Biology and ToxicologySeptember 25, 2024Xue Xiao, Jia-Xin Li, Hui-Hua Li, Fei Tenginsert, while macrophages were positioned in the lower chamber and treated with A779 (10–5 mol/L) (HY-P0216, MCE) and/or LPS (1 ng/μL) for an additional 24 h. Statistical analysis All results were represented

(4) The ACE2/Ang-(1-7)/MasR axis alleviates brain injury after cardiopulmonary resuscitation in rabbits by activating PI3K/Akt signalingTranslational NeuroscienceApril 11, 2024Jing Cheng, Hong Yang, Fang Chen, Li Qiu, Fang Chen, Yanhua Du, Xiangping Mengreceived subcutaneous injections of Ang-(1-7) and A779 solution (a MasR antagonist; 576 μg/kg/day; HY-P0216, MedChemExpress) immediately after resuscitation; (e) in the CA/CPR + LY294002 group, the rabbits underwent

(5) Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytesSignal Transduction and Targeted TherapyFebruary 14, 2024Xinyi Yang, Xu Zheng, Yuqi Zhu, Xiaying Zhao, Jun Liu, Jiangna Xun, Songhua Yuan, Jun Chen, Hanyu Pan, Jinlong Yang, et al.Fluor488-conjugated Antibody (IC050G). Anti-Flag Magnetic Beads (HY-K0207) and ACE2/ANG (1-7) inhibitor-A779 (HY-P0216) were purchased from MCE. The Sipke of SARS-CoV-2 (DRA59) was purchased from novoprotein (Shanghai,

(6) The Ang-(1-7)/MasR axis ameliorates neuroinflammation in hypothermic traumatic brain injury in mice by modulating phenotypic transformation of microgliaPloS oneJanuary 1, 2024Ye D, Liu J, Lin L, Hou P, Feng T, Wang S.treated with LPS (1 μg/mL, L3025, Sigma), Ang-(1–7) (10−6 mol/L, HY-12403, MCE), and A779 (10−5 mol/L, HY-P0216, MCE) for 24 h. RNA extraction and quantitative reverse transcription-PCR Total RNA was extracted

(7) Ang-(1-7)/MasR axis promotes functional recovery after spinal cord injury by regulating microglia/macrophage polarizationCell & bioscienceFebruary 4, 2023Gu G, Zhu B, Ren J, Song X, Fan B, Ding H, Shang J, Wu H, Li J, Wang H, et al.treated with LPS (100 ng/ mL, L3025, Sigma), Ang-(1–7) (10−6 mol/L, HY-12403, MCE) and A779 (10−5 mol/L, HY-P0216, MCE) for 24 h, respectively. Animals 200 female Wistar rats, with each weighing 200-220 g on average,

(8) Recombinant human angiotensin-converting enzyme 2 plays a protective role in mice with sepsis-induced cardiac dysfunction through multiple signaling pathways dependent on converting angiotensin II to angiotensin 1-7Annals of translational medicineJanuary 15, 2023Wu C, Chen Y, Zhou P, Hu Z.dysfunction were also distributed randomly to the LPS + rhACE2 +A779 group, receiving 10 mg/kg A779, (HY-P0216, MedChemExpress, Monmouth Junction, NJ, USA) by tail vein injection (34) prior to receiving 200 µg/kg

(9) [Effects and related mechanism of angiotensin-(1-7) on Toll-like receptor 4-mediated oxidative stress in human umbilical vein endothelial cells]Zhonghua xin xue guan bing za zhiMarch 24, 2017Yan WF, Xue JJ, Yang HY, Liang B, Yang ZM.

(10) The Intensity of Home Care Acuity Scale. Part oneCaring : National Association for Home Care magazineJuly 1, 1997Jones J, Scemons D, Stafford DM.

(11) "ACE-2/Ang1-7/Mas cascade mediates ACE inhibitor, captopril, protective effects in estrogen-deficient osteoporotic rats"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieJanuary 1, 0001"Abuohashish HM, Ahmed MM, Sabry D, Khattab MM, Al-Rejaie SS."

(12) Angiotensin (1-7) ameliorates the structural and biochemical alterations of ovariectomy-induced osteoporosis in rats via activation of ACE-2/Mas receptor axisScientific reportsJanuary 1, 0001"Abuohashish HM, Ahmed MM, Sabry D, Khattab MM, Al-Rejaie SS."

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A 779 from MedChemExpress

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A 779 from MedChemExpress

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