Fig 1: rhIL-22BP-ABD decreases the expression of pro-inflammatory cytokines and STAT3 signaling pathway in psoriatic mice. A The representative images of the H&E-stained skin sections of different treatment groups. B Expression of IL-6 in different treatment groups by ELISA (n = 5). C Expression of TNF-α in different treatment groups by ELISA (n = 5). D The expressions of IL-22, IFN-γ, IL-1β and p-STAT3 proteins in different treatment groups were detected by Western blot. Quantitative data are presented as mean ± standard deviation (n = 5). Statistical significance is indicated as follows: ****P < 0.0001, and ns means no significant difference