Alpha Synuclein Pre-formed Fibrils SPR-324 from StressMarq Biosciences Inc

Product Specs
ItemAlpha Synuclein Pre-formed Fibrils
CompanyStressMarq Biosciences Inc
Price Supplier Page View Company Product Page
Catalog NumberSPR-324
ApplicationsWB, SDS-PAGE, In vivo assay, In vitro assay
Size100 µg
Research AreaNeuroscience, Neurodegeneration, Alzheimer's Disease, Tangles & Tau, Neuroscience, Neurodegeneration, Parkinson's Disease, Synuclein, Neuroscience, Neurodegeneration, Multiple System Atrophy
NCBI Full Gene Namesynuclein, alpha
NCBI Gene AliasesNACP, alpha-Syn, alphaSYN
Conjugate/TagNo tag
TypeProtein
Source/Expression SystemE. coli
Purity>95%
SpeciesMouse

Sequence

MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM GKGEEGYPQE GILEDMPVDP GSEAYEMPSE EGYQDYEPEA

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StressMarq Biosciences Inc

117-1537 Hillside Ave.

Victoria, British Columbia V8T 4Y2

Canada

Phone: +1-250-294-9065
Fax: 1-250-294-9025

Email: info@stressmarq.com

Company Profile

Website: http://www.stressmarq.com

(1) Fluorescence Detection of Alpha-Synuclein Aggregates in the Gut Using a Peptide ProbeACS Chem NeurosciMarch 18, 2026Rachel Sim, Jeremy Lee, Joey Chieng, Ko Hui Tan, Grace Lim, Aaron Foo, Sunny Hei Wong, Kah Leong Lim, Kaicheng LiangInstruments LLC, US). PFF-injected Mouse Tissue Preparation 15 μL of 2 mg/mL α-syn PFF (StressMarq SPR-324) were sonicated in an ultrasonic bath sonicator for 2.5 h at the following conditions: sweep, 37 Hz

(2) Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humansnpj Parkinson's DiseaseFebruary 17, 2026Rachel N. Clark, Reese E. Landes, Muslim Abbas, Victoria G. Mistretta, Jhanvi R. Jhaveri, Kieran A. DeLoatch, Jonathan Franks, Jun Chen, Kelvin C. Luk, Xiaoming Hu, et al.ATTO647 dye (ATTO-TEC, GmbH, Germany, Cat. No. AD 647N-31) was conjugated to PFFs (StressMarq Cat. No. SPR-324) by StressMarq Biosciences, following published protocols for PFF preparation132. Protein conjugation

(3) Artificial miRNA-mediated reduction of SNCA for the treatment of α-synucleinopathiesMolecular therapy : the journal of the American Society of Gene TherapyFebruary 4, 2026Elmer B, Wischhof E, Chan T, Mahendran TA, Ardinger J, Richards B, Liu D, Bladon JH, He Y, Jackson R, et al.

(4) Glycerol 3-phosphate acyltransferase exacerbates α-synuclein-induced toxicity by increasing lipid peroxidationNature communicationsJanuary 19, 2026Ren M, Lim GGY, Tang W, Lim KL.imagesc. Synuclein preformed fibril preparation In total, 15 μl of 2 mg/ml synuclein PFF (StressMarq SPR-324) aliquoted into screw-capped tubes were sonicated in an ultrasonic bath sonicator for 2.5 h at the following

(5) Development of convolutional neural networks for automated brain-wide histopathological analysis in mouse models of synucleinopathiesNPJ Parkinson's diseaseNovember 18, 2025Barber-Janer A, Van Acker E, Vonck E, Plessers D, Rosada F, Van den Haute C, Baekelandt V, Peelaerts W.

(6) Chaperone nanomotors with chemotactic ability for the treatment of Parkinson's diseaseScience advancesSeptember 19, 2025Wang W, Xia X, Zhang Z, Zhu Q, Chen Y, Zhang Y, Chen L, Mao C, Wan M.

(7) Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson's diseaseJournal of neuroinflammationJuly 19, 2025Han C, Wang H, Zhang M, Wu L, Wang A, Yang P, Gao Y, Zhang C, Gao J, Xue T, et al.

(8) Facile generation of drug-like conformational antibodies specific for amyloid fibrilsNature chemical biologyJune 1, 2025Desai AA, Zupancic JM, Trzeciakiewicz H, Gerson JE, DuBois KN, Skinner ME, Sharkey LM, McArthur N, Ferris SP, Bhatt NN, et al.N-acetylated α-synuclein fibrils (Stressmarq, SPR-332), and mouse α-synuclein fibrils (Stressmarq, SPR-324) were first sonicated for 5 min (30 s on, 30 s off) before loading onto the nitrocellulose membrane.

(9) Inhibiting Immune Crosstalk by Modulation of the Intracellular Function and Extracellular Environment of Diseased Microglia to Boost Parkinson's Disease TherapyACS nanoMay 27, 2025Zheng Q, Gao Y, Han M, Wang Y, Liu H, Cao G, Wang T, Zhang H, Li Z.

(10) Trehalose-releasing nanogels reduce α-synuclein-induced Lewy body-like inclusions in primary mouse hippocampal neuronsJournal of materials chemistry. BMay 21, 2025Maruf A, Gerasymchuk D, Hlushchuk I, Er S, Milewska M, Chmielarz P, Domanskyi A, Airavaara M, Wandzik I.

(11) Astrocytes carrying LRRK2 G2019S exhibit increased levels of clusterin chaperone via miR-22-5p and reduced ability to take up α-synuclein fibrilsActa neuropathologica communicationsMay 12, 2025Filippini A, Carini G, Barbon A, Gennarelli M, Russo I.described [15, 46, 48], and resuspended in PBS. While mouse α-syn pffs were acquired by StressMarq (SPR-324). pHrodo-labeled α-syn pffs were generated by using the pHrodoTM iFL Green Microscale Protein Labeling

(12) Peptidomimetics Activating the Proteasome: A New Perspective for Parkinson's TreatmentJournal of medicinal chemistryApril 24, 2025Trepczyk K, Er S, Hlushchuk I, Airavaara M, Alwani A, Maziarz K, Chmielarz P, Słomska K, Wieczerzak E, Jankowska E.

(13) 14-3-3θ phosphorylation exacerbates alpha-synuclein aggregation and toxicityNeurobiology of DiseaseMarch 1, 2025Bing Wang, Mary Gannon, Rudradip Pattanayak, Kasandra Scholz, Frank Sanders Pair, William J. Stone, Roschongporn Ekkatine, Zhongyu Liu, Talene A. YacoubianCre+/− S232D mice were injected with mouse recombinant αsyn PFFs (Type 1), purchased from StressMarq (#SPR-324), following the protocol described in Underwood et al. (Underwood et al., 2021) with slight modifications.

(14) PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's diseaseNPJ Parkinson's diseaseAugust 6, 2024Cao B, Chen X, Li Y, Zhou T, Chen N, Guo Y, Zhao M, Guo C, Shi Y, Wang Q, et al.biological replicates. Primary dopaminergic neurons and SH-SY5Y were stimulated by PFFs (500 ng/mL, Cat#No.SPR324, StressMarq, Canada) for 24 h and BV2 was stimulated by 500 ng/mL PFFs for 12 h. Plasmid construction The

(15) Genetic and pharmacological reduction of CDK14 mitigates synucleinopathyCell death & diseaseApril 4, 2024Parmasad JA, Ricke KM, Nguyen B, Stykel MG, Buchner-Duby B, Bruce A, Geertsma HM, Lian E, Lengacher NA, Callaghan SM, et al.

(16) A Novel NOX Inhibitor Alleviates Parkinson’s Disease Pathology in PFF-Injected MiceInternational Journal of Molecular SciencesSeptember 19, 2023Kwadwo Ofori, Anurupa Ghosh, Dinesh Kumar Verma, Darice Wheeler, Gabriela Cabrera, Jong-Bok Seo, Yong-Hwan Kim12 months for stereotaxic injection with 2 μL of mouse α-syn PFF (2.5 μg/μL in PBS, 5 μg each side, SPR-324, StressMarq) in the dorsal striatum bilaterally, as reported previously [17]. The coordinates for injection

(17) Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrilsbioRxiv : the preprint server for biologyJuly 4, 2023Desai AA, Zupancic JM, Trzeciakiewicz H, Gerson JE, DuBois KN, Skinner ME, Sharkey LM, McArthur N, Ferris SP, Bhatt NN, et al.

(18) Targeted degradation of ⍺-synuclein aggregates in Parkinson's disease using the AUTOTAC technologyMolecular neurodegenerationJune 24, 2023Lee J, Sung KW, Bae EJ, Yoon D, Kim D, Lee JS, Park DH, Park DY, Mun SR, Kwon SC, et al.(BioPORTER QuikEase Protein Delivery Kit, Sigma) following the provider’s instruction. The mouse α-syn PFFs were obtained from StressMarq (SPR-324). Prior to treatment, PFFs were sonicated at 20% amplitude, 1 s pulse on and off for 30 s (SONICS Vibra

(19) A Novel NOX Inhibitor Treatment Attenuates Parkinson's Disease-Related Pathology in Mouse ModelsInternational journal of molecular sciencesApril 12, 2022Ghosh AA, Verma DK, Cabrera G, Ofori K, Hernandez-Quijada K, Kim JK, Chung JH, Moore M, Moon SH, Seo JB, et al.months and stereotaxically injected with 2.5 µL of mouse α-syn PFF (2 μg/μL in PBS, 5 µg each side, SPR-324, StressMarq) in the dorsal striatum bilaterally, as reported previously [29,30,38]. 4.7. Gavaging Schedule The

(20) Cell Culture Media, Unlike the Presence of Insulin, Affect α-Synuclein Aggregation in Dopaminergic NeuronsBiomoleculesApril 9, 2022Hlushchuk I, Barut J, Airavaara M, Luk K, Domanskyi A, Chmielarz P.experiments on cortical or hippocampal neurons, commercially available mouse α-syn PFFs (StressMarq, SPR-324, Cadboro Bay, Victoria, BC, Canada) were diluted in 1× PBS to a final concentration of 100 µg/mL and

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Alpha Synuclein Pre-formed Fibrils (Type 1)

Alpha Synuclein Pre-formed Fibrils (Type 1)

Alpha Synuclein Pre-formed Fibrils (Type 1)

Alpha Synuclein Pre-formed Fibrils (Type 1)

Alpha Synuclein Pre-formed Fibrils (Type 1)

Alpha Synuclein Pre-formed Fibrils from StressMarq Biosciences Inc

Description

Sequence

StressMarq Biosciences Inc

Citations (25)

Reviews

Alpha Synuclein Pre-formed Fibrils from StressMarq Biosciences Inc

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