Human BDNF Recombinant Protein PHC7074 from Thermo Fisher Scientific

Product Specs
ItemHuman BDNF Recombinant Protein
CompanyThermo Fisher Scientific
Price Supplier Page View Company Product Page
Catalog NumberPHC7074
Regulatory StatusFor Research Use Only. Not for use in diagnostic procedures
Size10 µg
ApplicationsCELL CULTURE

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Thermo Fisher Scientific

168 Third Avenue

Waltham, MA 02451

United States

Phone: 800-678-5599

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Website: www.thermofisher.com

(1) Activation of the G-protein coupled estrogen receptor 1 (GPER1) reduces transient receptor potential vanilloid 1 (TRPV1) activity and human iPSC-derived nociceptive neuron firingStem Cell Res TherJuly 7, 2026Oliver Dräger, Angelique Grell, Asaria E. Vogel, Erhard Wischmeyer, Beatrice A. NossekThermo Fisher Scientific, Darmstadt, Germany), brain-derived neurotrophic factor (BDNF, 10 ng/ml, # phc7074, Thermo Fisher Scientific, Darmstadt, Germany) and glial cell line-derived neurotrophic factor (GDNF,

(2) A human iPSC-derived sensory neuron platform for high-throughput discovery of neuroprotectants against chemotherapy-induced peripheral neuropathyCell Rep MedMay 19, 2026Veselina Petrova, Caitlin E. Mills, Clemens Hug, Aysel Cetinkaya-Fisgin, Jennifer Splaine, Sepideh Fouladzadeh, Sara Hakim, Rasheen Powell, Shannon Zhen, Mirra Chung, et al.(Thermo Fisher Scientific, cat. no. A1370701), supplemented with 25 ng/mL BDNF (Thermo Fisher Scientific, cat. no. PHC7074), 25 ng/mL GDNF (Thermo Fisher Scientific, cat. no. PHC7045), 25 ng/mL β-NGF (Thermo Fisher Scientific,

(3) Perfluorooctanoic acid (PFOA) induces lipid accumulation, oxidative stress, and reduced neurogenesis in primary human neuronal progenitor cellsFront ToxicolMay 15, 2026William P. Marinello, Mark J. Zylka1% Glutamax (100×), 10 ng/mL NT-3 (Life Technologies; PHC7036) and 10 ng/mL BDNF (Life Technologies; PHC7074). Fresh media was exchanged every 2 days. 2.3 Chemical exposure In all experiments, phNPCs were plated

(4) A class of deep intronic IGHMBP2 variants activate a shared cryptic splice donor, enabling correction of select variants with a single antisense oligonucleotidemedRxivMay 5, 2026Sarah Silverstein, Andrew D Nguyen, Rotem Orbach, Sandra Donkervoort, Thomas Cassini, Mary Koziura, Véronique Bolduc, Audrey M Winkelsas, Ester Masati, Shreya Nandi, et al.(Gibco, 11140050)) supplemented with 2ul/ml doxycycline, 10μM ROCK-inhibitor, 10ng/ml BDNF (Gibco, PHC7074), 10ng/μl GDNF (Gibco, 450–10-10UG), 10ng/μl CNTF (Gibco, 450–13-20UG), 10ng/ml NT-3 (Gibco, 450–03-10UG),

(5) The role of MICOS in modulating mitochondrial dynamics and structural changes in vulnerable regions of Alzheimer’s DiseasebioRxivApril 6, 2026Bryanna Shao, Bartosz Kula, Han Le, Prasanna Venkhatesh, Prasanna Katti, Andrea G. Marshall, Siddharth Chittaranjan, Suraj Thapilyal, Hari Kalpana Kalpana, C. Nivedya, et al.μM), doxycycline (2 μg/mL), and human BDNF recombinant protein (1 μg/mL; Thermo Fisher Scientific, #PHC7074). Media was changed daily. Neuronal cultures were then maintained for 21 days, with half-medium changes

(6) SSEA3 and CD105 positivity are associated with the treatment potency of human neural crest-derived nasal turbinate stem cells for Alzheimer's diseaseTranslational neurodegenerationMarch 3, 2026Lim JY, Lee JE, Lee M, Shim H, Park SI, Park SA, Jeun SS, Wang SM, Kim S, Yang SH, et al.(Thermo Fisher Scientific, 100-18B), brain-derived neurotrophic factor (BDNF) (Thermo Fisher Scientific, PHC7074), and laminin, and the medium was changed every 3–4 days. Mature COs, cultured for 40–50 days, were

(7) Statins and genetic inhibition of the mevalonate pathway activate an ATF3-STMN2 regenerative programbioRxivFebruary 26, 2026Matthew Nolan, Sandeep Aryal, I. Sandra Ndayambaje, Maize Cao, Peyton Lee, Moriah Hovde, Shuqi Yun, Josette Wlaschin, Aaron Held, Hortense Beaussant, et al.B27 supplement (Gibco, #17504–044), 1% GlutaMax (Gibco, 35050061), 1ng/mL BDNF (Life Technologies, PHC7074), 1ng/ml NT3 (Peprotech, #450–03), 50ng/ml Aphidicolin (CellSignaling, #32774) and 2μg/mL doxycycline

(8) Blocking RAN translation without altering repeat RNAs rescues C9ORF72 -related ALS and FTD phenotypesScienceFebruary 5, 2026Xin Jiang, Laure Schaeffer, Divya Patni, Tommaso Russo, Chao-Zong Lee, Corey Aguilar, Christine Marques, Karen Jansen-West, Marian Hruska-Plochan, Ananya Ray-Soni, et al.GlutaMax (Gibco, 35050061), 0.2% 2-Mercaptoethanol (Gibco, 31350010), 1 ng/ml BDNF (Life Technologies, PHC7074), 1 ng/ml GDNF (Stemcell Technologies, 78139.1), 1 ng/ml IGF-1 (R&D Systems, 291-G1-200), 1 ng/ml CNTF

(9) Dysregulated Expression of Inflammasome and Extracellular Matrix Genes in C9orf72 -ALS/FTD MicrogliaASN NeuroDecember 31, 2025Louise Thiry, Nisha S. Pulimood, Ye Man Tang, Stefano StifaniCat. No. 291-G1-200), brain-derived neurotrophic factor (10 ng/mL; Thermo-Fisher Scientific; Cat. No. PHC7074) and ciliary neurotrophic factor (10 ng/mL; R&D Systems; Cat. No. 257-NT-050). Motor neuron culture

(10) Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndromeEMBO molecular medicineDecember 1, 2025Sharma Y, Bhatia P, Rangappa G, Saha S, Raghu P.Acids,Gibco,11140-050 Penstrep,Gibco,15140-122 Glutamax,Gibco,35050-061 SB-43142,Sigma-Aldrich,301836-41-9 LDN,Sigma-Aldrich,SML0559 FGF2,Gibco,PHG0369 EGF,Gibco,PHG0311 BDNF,Gibco,PHC7074 BDNF,Peprotech,450-02 GDNF,Gibco,PHC7041 NT3,Peprotech,450-03 Ascorbic acid,Sigma-Aldrich,A4544 dbcAMP,Sigma-Aldrich,D0627 DAPT,Sigma-Aldrich,D5942 AggreWell 800

(11) Mitochondrial structure and function in OCRL depleted cellsFrontiers in Cell and Developmental BiologyNovember 20, 2025Ron George Philip, Priyanka Bhatia, Yojet Sharma, Padinjat Raghupoly-L-ornithine/laminin and maintained in neural differentiation medium (NDM) supplemented with 10 ng/mL BDNF (Gibco # PHC7074), GDNF (Gibco #PHC7041), IGF (Gibco, #PHG0078) ascorbic acid (50 μM, Sigma # A4544), and dbcAMP (1000μM,

(12) Enhanced Schwann cell differentiation of skin‐derived neural crest‐like stem cells through the synergistic action of SOX10 and immobilized NRG1 signalingBioengineering & Translational MedicineNovember 1, 2025Ashis Kumar Podder, Pihu Mehrotra, Pedro Lei, Stelios T. AndreadisAscorbic acid (200 μg/mL), NRG1 (50 ng/mL, Sigma, Catalog # H7660), BDNF (10 ng/mL, Invitrogen, Catalog # PHC7074), RepSox (10 μM, Cayman Chemical, Catalog #14794) for 7 days. The medium was changed every alternate

(13) Lithium partially rescues gene expression and enhancer activity from heterozygous knockout of AKAP11 while inducing novel differential changesSci RepOctober 29, 2025Nargess Farhangdoost, Alessia Pietrantonio, Yumin Liu, Calwing Liao, Daniel Rochefort, Alain Pacis, Martin Alda, Patrick A. Dion, Boris Chaumette, Anouar Khayachi, et al.µg/ml (Sigma-Aldrich, Cat #A9501-1G), brain-derived neurotrophic factor 20 ng/ml (BDNF, GIBCO, Cat. #PHC7074), Wnt3a 10 ng/ml (R&D Systems, Cat. #5036-WN-500), and laminin 1 µg/ml (Gibco, Cat. #23017015) for 14

(14) Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregationBrain CommunicationsSeptember 1, 2025Ellen Sapp, Adel Boudi, Andrew Iwanowicz, Jillian Belgrad, Rachael Miller, Riannon Robertson, Daniel O’Reilly, Ken Yamada, Yunping Deng, Marion Joni, et al.cells were cultured continuously in NMM with brain derived neurotrophic factor (BDNF, 10 ng/mL, Gibco, PHC7074) and glial cell line derived neurotrophic factor (GDNF, 10 ng/mL, Gibco, PHC7075) 42 days after the

(15) Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCsBIO-PROTOCOLJuly 5, 2025Louise Thiry, Julien Sirois, Thomas M. Durcan, Stefano Stifanibrain–derived neurotrophic factor recombinant protein (BDNF) (Thermo Fisher Scientific, catalog number: PHC7074) 22. Recombinant human ciliary neurotrophic factor (CNTF) (R&D Systems, catalog number: 257-NT-050) 23.

(16) Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCsBio ProtocJuly 5, 2025Louise Thiry, Julien Sirois, Thomas M. Durcan, Stefano Stifanibrain–derived neurotrophic factor recombinant protein (BDNF) (Thermo Fisher Scientific, catalog number: PHC7074) 22. Recombinant human ciliary neurotrophic factor (CNTF) (R&D Systems, catalog number: 257-NT-050) 23.

(17) Starting a synthetic biological intelligence lab from scratchPatterns (N Y)April 23, 2025Md Sayed Tanveer, Dhruvik Patel, Hunter E. Schweiger, Kwaku Dad Abu-Bonsrah, Brad Watmuff, Azin Azadi, Sergey Pryshchep, Karthikeyan Narayanan, Christopher Puleo, Kannathal Natarajan, et al.maturation)",before −1,"10 μg in 20 μL distilled water for 0.5 mg/mL, further diluted in 20 mL of 0.1% BSA",PHC7074 Bovine serum albumin (BSA),Fisher BioReagents,"media (BDNF dilution, maintenance + maturation)",before

(18) Mutant huntingtin induces neuronal apoptosis via derepressing the non-canonical poly(A) polymerase PAPD5Nat CommunApril 9, 2025Zhefan Stephen Chen, Shaohong Isaac Peng, Lok I Leong, Terence Gall-Duncan, Nathan Siu Jun Wong, Tsz Ho Li, Xiao Lin, Yuming Wei, Alex Chun Koon, Junzhe Huang, et al.N2B27 medium supplemented with 10 ng/ml human brain-derived neurotrophic factor recombinant protein (PHC7074, Thermo Fisher Scientific) and 10 ng/ml human glial cell line-derived neurotrophic factor recombinant

(19) Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington’s Disease Prefrontal CortexJournal of Huntington's DiseaseFebruary 7, 2025Tiziana Petrozziello, Sommer S. Huntress, Ayleen L. Castillo-Torres, James P. Quinn, Theresa R. Connors, Corinne A. Auger, Alexandra N. Mills, Spencer E. Kim, Sophia Liu, Farah Mahmood, et al.observed. Upon successful neural development, cells were cultured continuously in NMM with BDNF (10ng/mL; #PHC7074, Gibco, ThermoFisher Scientific, MA) and GDNF (10 ng/mL, #PHC7075, Gibco, ThermoFisher Scientific, MA)

(20) Multifactorial approach is needed to unravel the maturation phases of human neurons derived from induced pluripotent stem cellsSci RepJanuary 21, 2025Maissa Ben Mahmoud, Anikó Rátkai, Krisztina Bauer, Norbert Bencsik, Attila Szücs, Katalin Schlett, Krisztián Tárnok2% of B27 Supplement and 1 μg/mL laminin, 10 ng/mL brain derived neurotrophic factors (BDNF, Gibco, #PHC7074), 10 ng/mL glial derived neurotrophic factor (GDNF, Gibco, #PHC7045), 1 mM dibutyryl cyclic-AMP (Sigma,

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Human BDNF Recombinant Protein from Thermo Fisher Scientific

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Human BDNF Recombinant Protein from Thermo Fisher Scientific

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