Fig 1: Prediction and validation of ENR targets. (A) Venn diagram illustrating the overlap among predicted ENR targets, inflammatory bowel disease‐related genes, and differentially expressed genes. (B) Protein–protein interaction network representing 90 key target proteins. (C) Sankey diagram displaying enriched KEGG and GO pathways for differentially expressed genes. (D) Comparison of mitochondrial complex protein homology across rats, humans, and zebrafish. (E) Molecular docking simulation diagram of CYC1 protein and ENR. (F) Surface plasmon resonance (SPR) analysis demonstrating binding affinity between ENR and the CYC1 protein.