Recombinant Human IL-2 Protein PHC0021 from Thermo Fisher Scientific

Product Specs
ItemRecombinant Human IL-2 Protein
CompanyThermo Fisher Scientific
Price Supplier Page
Catalog NumberPHC0021
Size100 µg
ApplicationsControl, ELISA, Functional assay, Immunohistochemistry, Western Blot
Formatno preservative
TypeRecombinant
SpeciesHuman
Molecule NameHuman IL-2
NCBI Full Gene Nameinterleukin 2
NCBI Gene AliasesIL-2, TCGF, lymphokine
Storage4° C

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Thermo Fisher Scientific

81 Wyman Street

Waltham, MA 02451

United States

Phone: 800-678-5599
Fax: 800-331-2286

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Website: www.thermofisher.com

(1) Ex vivo cytokine responses and metabolic reprogramming are associated with γδ T cell differentiation in Plasmodium falciparum placental malariaFront ImmunolApril 16, 2026Chris Marco Nana Mbianda, Bodin Darcisse Kwanou Tchakounte, Bernard Marie Bitye Zambo, Joséphine Ntankheuh Tchinkou, Derrick Atchombat Nyasse, Balotin Fogang, Rafael José Argüello, Lawrence Ayong, Rosette Megnekoumedium (Gibco, cat# 11020021, USA), supplemented with 100 IU/mL rhIL-2 (Thermo Fisher Scientific, cat# PHC0021, USA), 10% FBS (Gibco, cat# 10082147, USA), 1% Penicillin-Streptomycin (Gibco Thermo Fisher Scientific,

(2) Dysregulation of apolipoprotein o reprograms CCR7+CD4+T cell fate in primary autoimmune thrombocytopeniaiScienceNovember 21, 2025Tengda Li, Xiang Li, He Huangproteins","Chemicals, peptides, and recombinant proteins" ,, Human IL-2 Recombinant Protein,Thermo Fisher Scientific,PHC0021 Antimycin A,Sigma,1397-94-0 AICAR,Sigma,2627-69-2 ,, Critical commercial assays,Critical commercial

(3) Protocol for the biofabrication of immunocompetent tumor-on-chip models from patient solid tumors for assessment of anticancer therapiesSTAR ProtocolsSeptember 19, 2025Martin Nurmik, Ségolène Ladaigue, Isabella Hofer, Auriane Debache, Irina Veith, Fatima Mechta-Grigoriou, Stephanie Descroix, Gerard Zalcman, Maria Carla Parrinisupernatant.19.Resuspend the cells in requisite amount of Medium A, supplemented with 30 ng/mL of rIL-2 (Gibco, #PHC0021), to obtain approximately 5000 CD8+ TILs cells per 100 μL of media.20.Seed 200 μL of CD8+ cell suspension

(4) Bioengineering a Patient‐Derived Vascularized Lung Tumor‐on‐Chip Model to Decipher Immunomodulation by the EndotheliumAdvanced Healthcare MaterialsSeptember 1, 2025Christine Lansche, Ségolène Ladaigue, Giacomo Gropplero, Nicolas Zimmermann, Martin Nurmik, Irina Veith, Manh‐Louis Nguyen, Solenn Brosseau, Nicolas Poté, Pierre Mordant, et al.penicillin/streptomycin solution, 1% sodium pyruvate (Thermo‐Fisher Scientific, 11‐360‐070), 30 ng mL−1 of rIL‐2 (Gibco, #PHC0021). Primary lung CAFs were cultured into standard culture dishes DMEM/high glucose (Cytiva, SH30243.01)

(5) A 3D Tumor Spheroid Model with Robust T Cell Infiltration for Evaluating Immune Cell EngagersiScienceAugust 15, 2025Hin Ching Lo, Hana Choi, Kevin Kolahi, Samantha Rodriguez, Leiru Gonzalez, Felix Chu, Aditee Shrotre, Xi Zhao, Aloma L. D’Souza, Ron Ferrando, et al.12352200 DNase I,Invitrogen,Cat# 18068015 RPMI-1640 media,Gibco,Cat# 11875093 IL2,ThermoFisher,Cat# PHC0021 Pembrolizumab,Selleck Chem,Cat# A2005 EpCAM-CD3 bispecific antibody,Creative Biolabs,Cat# BSSG-079 DAPI,Akoya,Cat#

(6) Immune targeting of triple-negative breast cancer through a clinically actionable STING agonist-CAR T cell platformCell Reports MedicineJuly 15, 2025Yuqing Zhang, Zehua Li, Jessica Ritter, Elliott J. Brea, Navin R. Mahadevan, Deborah A. Dillon, Sung-Rye Park, Eric Minwei Liu, Michael Y. Tolstorukov, William E. McGourty, et al.314042-01-8 "T cell TransAct™, human",Miltenyi Biotec,Cat# 130-111-160 Human IL-2,Thermo Fisher Scientific,Cat# PHC0021 Human IL-7,Thermo Fisher Scientific,Cat# PHC0075 Human IL-15,Thermo Fisher Scientific,Cat# PHC9154 ,, Critical

(7) Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indicationsScientific ReportsJanuary 31, 2025Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, et al.Scientific, cat# 26050-088) + 500 U/ml Gibco recombinant human (rh) IL-2 (Thermo Fisher Scientific, cat# PHC0021). For primary NK cells, human leukopaks were procured from the San Diego Blood Bank and processed using

(8) Dynamics of tissue repair regulatory T cells and damage in acute Trypanosoma cruzi infectionPLoS pathogensJanuary 1, 2025Boccardo S, Rodriguez C, Gimenez CMS, Araujo Furlan CL, Abrate CP, Almada L, Saldivia Concepción MA, Skewes-Cox P, Rao SPS, Mukdsi JH, et al.detailed above. When indicated, i.p. injections also contained 1 μg of recombinant human IL-2 (Gibco, Cat# PHC0021). PBS was used as vehicle. For treatments with neutralizing antibodies, mice received i.p. injections

(9) Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cellsJournal of Translational MedicineSeptember 27, 2024Angela C. Court, Eliseo Parra-Crisóstomo, Pablo Castro-Córdova, Luiza Abdo, Emmanuel Arthur Albuquerque Aragão, Rocío Lorca, Fernando E. Figueroa, Martín Hernán Bonamino, Maroun Khouryresuspended in 1 mL pf RPMI medium supplemented with 2 mM l-glutamine, 50 U/mL IL-2 (ThermoFisher Scientific #PHC0021), 100 U/mL penicillin, 100 µg/mL streptomycin, 10 mM HEPES, 0.1 mM pyruvate and 20% fetal calf serum

(10) Enhancing immunotherapy through PD‐L1 upregulation: the promising combination of anti‐PD‐L1 plus mTOR inhibitorsMolecular OncologySeptember 11, 2024Anna Hernández‐Prat, Alejo Rodriguez‐Vida, Laura Cardona, Mengjuan Qin, Oriol Arpí‐Llucià, Luis Soria‐Jiménez, Sílvia Menendez, Fabricio Gerel Quimis, Miguel Galindo, Edurne Arriola, et al.l‐glutamine (2 mm·L−1), penicillin/streptomycin (100 U/100 μg·mL−1), 10% FBS and IL‐2 0.3 ng·mL−1 (PHC0021; Fisher Scientific) and maintained at 37 °C under a 5% CO2 humidified atmosphere. PBMC were incubated

(11) UBX-390: A Novel Androgen Receptor Degrader for Therapeutic Intervention in Prostate CancerAdvanced science (Weinheim, Baden-Wurttemberg, Germany)September 1, 2024Lee S, Kim HR, Woo Y, Kim J, Kim HW, Park JY, Suh B, Choi Y, Ahn J, Ryu JH, et al.Unit). Chemicals and Antibodies The chemicals used in this study were DHT (D‐073; Sigma‐Aldrich), IL‐2 (PHC0021, Gibco, Waltham, MA, USA), bortezomib (S1013; Selleckchem, Houston, TX, USA), MLN4924 (5.05477.0001;

(12) Effect and mechanism of T lymphocytes on human induced pluripotent stem cell-derived cardiomyocytes via ProteomicsStem cell research & therapyJuly 29, 2024Ye J, Xu S, Liu X, Zhang Q, Li X, Zhang H, Ma J, Leng L, Zhang S.stimulation of Dynabeads human CD3/CD28 (11132D, Thermo-Fisher Scientific) and recombinant human IL-2 (PHC0021, Thermo-Fisher Scientific) at the prescribed beads-to-cell ratio of 1:1. Then, hiPSC-CMs were introduced

(13) A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organismCommun Med (Lond)March 26, 2024Ptacin JL, Ma L, Caffaro CE, Acuff NV, Germar K, Severy P, Qu Y, Vela JL, Cai X, San Jose KM, et al.Rβ-Fc Sino 10696-H02H). Recombinant human IL-2 (hIL-2) was purchased from Thermo Scientific (Cat. No. PHC0021) and prepared at a stock concentration of 64.5 µM. Using a Biacore 4000 optical biosensor, the Fc-IL-2

(14) Cancer stem cell-derived CHI3L1 activates the MAF/CTLA4 signaling pathway to promote immune escape in triple-negative breast cancerJournal of translational medicineOctober 14, 2023Ji S, Yu H, Zhou D, Fan X, Duan Y, Tan Y, Lang M, Shao G.Dynabeads™ human T activator CD3/CD28 (Thermo Fisher, 11132D, USA) and hrIL-2 (20 I.U./mL, Thermo Fisher, PHC0021, USA). For exogenous treatments, 20 μg/mL anti-CTLA4 ( Bio X Cell, BN13, USA) (BCSCs-231-T + anti-CTLA4),

(15) Cell Granularity Reflects Immune Cell Function and Enables Selection of Lymphocytes with Superior Attributes for ImmunotherapyAdvanced ScienceOctober 1, 2023Tongjin Wu, Joel Heng Loong Tan, Wei‐Xiang Sin, Yen Hoon Luah, Sue Yee Tan, Myra Goh, Michael E. Birnbaum, Qingfeng Chen, Lih Feng Cheowactivated using anti‐CD3/CD28 Dynabeads (3:1 bead‐to‐cell ratio) (Gibco) with 5 ng mL−1 IL‐2 (Gibco, PHC0021) supplemented. In some experiments, the expanded T cells were re‐stimulated by anti‐CD3/CD28 microbeads

(16) Development of a Patient-Derived 3D Immuno-Oncology Platform to Potentiate Immunotherapy Responses in Ascites-Derived Circulating Tumor CellsCancersAugust 16, 2023Gerton TJ, Green A, Campisi M, Chen M, Gjeci I, Mahadevan N, Lee CAA, Mishra R, Vo HV, Haratani K, et al.The activated T cells were cultured in the complete medium with 100 U/mL of human IL-2 (ThermoFisher, PHC0021, Waltham, MA, USA), and the medium and IL-2 were refreshed every three days. After 14 days of activation,

(17) Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune EvasionCellsJanuary 10, 2023Peng W, Ye L, Xue Q, Wei X, Wang Z, Xiang X, Zhang S, Zhang P, Wang H, Zhou Q.ThermoFisher Scientific) for 2 to 3 days in the RPMI 1640 medium containing human rIL-2 (20 U/mL, #PHC0021, ThermoFisher Scientific) and 10% heat-inactivated FBS. Activated CD8+T cells were cultured for 4–6

(18) Cas9 exo-endonuclease eliminates chromosomal translocations during genome editingNature CommunicationsDecember 1, 2022Jianhang Yin et al.cultured in RPMI 1640 (Corning) with 30 units/mL recombinant human interleukin-2 (IL-2, Gibco, cat. no. PHC0021), glutamine (Corning), 15% fetal bovine serum (FBS, Excell Bio), and penicillin/streptomycin (Corning)

(19) BNT162b2-induced neutralizing and non-neutralizing antibody functions against SARS-CoV-2 diminish with ageCell reportsOctober 25, 2022Bates TA, Lu P, Kang YJ, Schoen D, Thornton M, McBride SK, Park C, Kim D, Messer WB, Curlin ME, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, Recombinant human IL-2,Gibco,Cat#PHC0021 recombinant SARS-CoV-2 spike receptor binding domain,BEI Resources,NR-52309 recombinant SARS-CoV-2

(20) PERK reprograms hematopoietic progenitor cells to direct tumor-promoting myelopoiesis in the spleenThe Journal of experimental medicineApril 4, 2022Liu M, Wu C, Luo S, Hua Q, Chen HT, Weng Y, Xu J, Lin H, Wang L, Li J, et al.Thermo Fisher Scientific) and cultured in RPMI 1640 supplemented with 10% FBS, 20 U/ml recombinant IL-2 (PHC0021; Thermo Fisher Scientific), 1 μg/ml anti-CD3 (16-0031; RRID: AB_2865574; Thermo Fisher Scientific),

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Recombinant Human IL-2 Protein from Thermo Fisher Scientific

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Recombinant Human IL-2 Protein from Thermo Fisher Scientific

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