Fig 2: MiR-21 reduces myocardial cell apoptosis by targeting FGF1: (a) changes of miR-21 expression; (b) changes of FGF1 expression; (c) effects of miR-21 and FGF1 on myocardial cell apoptosis. A: in comparison with the normal group, P < 0.05; B: in comparison with the cell model group, P < 0.05; C: in comparison with the miR-NC group, P < 0.05; D: in comparison with the miR-21 minics group, P < 0.05; E: in comparison with the sh-FGF1 group, P < 0.05.

Fig 3: The expression of miR-21 and FGF1 in myocardial tissues: (a) changes of miR-21 in rats; (b) changes of FGF1 in rats. A: in comparison with the CON group, P < 0.05; B: in comparison with the Sham group, P < 0.05; C: in comparison with the model group, P < 0.05; D: in comparison with the miR-21 group, P < 0.05; E: in comparison with FGF1, P < 0.05. CON: control group.

Fig 4: Correlation analysis: (a) analysis of correlation between miR-21 and FGF1; (b) analysis of correlation between miR-21 and DBP; (c) analysis of correlation between miR-21 and SBP; (d) analysis of correlation between miR-21 and HR; (e) analysis of correlation between miR-21 and CF; (f) analysis of correlation between miR-21 and INF; (g) analysis of correlation between miR-21 and VEGF; (h) analysis of correlation between miR-21 and bax; (i) analysis of correlation between miR-21 and bcl-2; (j) analysis of correlation between FGF1 and DBP; (k) analysis of correlation between FGF1 and SBP; (l) analysis of correlation between FGF1 and HR. (m) analysis of correlation between FGF1 and CF; (n) analysis of correlation between FGF1 and INF; (o) analysis of correlation between FGF1 and VEGF; (p) analysis of correlation between FGF1 and bax; (q) analysis of correlation between FGF1 and bcl-2. DBP: diastolic blood pressure; SBP: systolic blood pressure; HR: heart rate; CF: coronary flow.