Recombinant SARS-CoV-2 Spike S2 Subunit His-tag Protein, CF 10594-CV-100 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemRecombinant SARS-CoV-2 Spike S2 Subunit His-tag Protein, CF
CompanyR&D Systems, a Bio-Techne Brand
Price $629.00Supplier Page View Company Product Page
Catalog Number10594-CV-100
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose
ApplicationsBioactivity
Size100 ug
Conjugate/TagUnconjugated
Purity>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
Molecule NameSpike S2 Subunit
Source/Expression SystemHEK293-derived Recombinant SARS-CoV-2 Spike S2 Subunit His-tag Protein, CF
Molecular WeightObserved: 80-100 kDa, under reducing conditions
Theoretical: 60 kDa
SpeciesSARS-CoV-2
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution
NCBI Gene Aliasesspike glycoprotein

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Endemic penetrance of SARS-CoV-2 has impacted marginally on immunity to spike protein of human coronavirusesCommunications BiologyJanuary 3, 2026Tara Lancaster, Gokhan Tut, Panagiota Sylla, David Bone, Christopher Bentley, Eliska Spalkova, Azar Jadir, Rachel Bruton, Katie Spencer, Soumyajit Mallick, et al.SARS-CoV-2 S1 protein (R&D Systems, 10569-CV-100) or recombinant SARS-CoV-2 S2 protein (R&D Systems, 10594-CV-100) at a concentration of 500 µg/ml in PBS, or with PBS alone. Plasma was then diluted at 1:5000 in diluent

(2) The monomeric but not homotrimeric spike protein of SARS-CoV-2 activates TLR4 signalingMolecular biology reportsJune 23, 2025Lübow C, Weindl G.proteins (all from Bio-Techne GmbH, Wiesbaden, Germany) were used: S1 subunit (10569-CV-100), S2 subunit (10594-CV-100), spike protein (10549-CV-100), spike (GCN4-IZ) protein (10561-CV-100), B.1.1.7 spike (GCN4-IZ) protein

(3) Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopyNature communicationsJanuary 2, 2025Zhang Q, Rosa RSL, Ray A, Durlet K, Dorrazehi GM, Bernardi RC, Alsteens D.

(4) An Optimised Indirect ELISA Protocol for Detection and Quantification of Anti-viral Antibodies in Human Plasma or Serum: A Case Study Using SARS-CoV-2Bio ProtocDecember 20, 2023Claire Baine, Jackson Sembera, Gerald Kevin Oluka, Joseph Ssebwana Katende, Violet Ankunda, Jennifer Serwanganumber: 10549-CV-01M)Recombinant SARS-CoV-2 Spike S2 Subunit protein (R&D Systems, catalog number: 10594-CV-100)SARS-CoV-2 RBD (S1) S-protein obtained from a pHL-sec expression vector in HEK 293T/17 cells [obtained

(5) Investigation of SARS-CoV-2 individual proteins reveals the in vitro and in vivo immunogenicity of membrane proteinScientific reportsDecember 18, 2023Haystead T, Lee E, Cho K, Gullickson G, Hughes P, Krafsur G, Freeze R, Scarneo S.Spike Protein S1 Subunit,R&D Systems,10569-CV-100 SARS-CoV-2 Spike Protein S2 Subunit,R&D Systems,10594-CV-100 SARS-CoV-2 Spike Protein RBD Subunit,R&D Systems,10500-CV-100 SARS-CoV-2 Spike Protein Full Length,R&D Systems

(6) Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection historyScientific reportsAugust 13, 2023Kiszel P, Sík P, Miklós J, Kajdácsi E, Sinkovits G, Cervenak L, Prohászka Z.biotecne",10569-CV-100 "Recombinant SARS-CoV-2 spike S2 subunit His-tag protein, CF","R&D systems, biotecne",10594-CV-100 "Recombinant SARS-CoV-2 nucleocapsid His protein, CF","R&D systems, biotecne",10474-CV-050 Software,Software,Software GraphPad

(7) Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronavirusesCell host & microbeJanuary 11, 2023Dacon C, Peng L, Lin TH, Tucker C, Lee CD, Cong Y, Wang L, Purser L, Cooper AJR, Williams JK, et al.40605-V08B-B HKU1-CoV spike,Sino Biological,Cat. # 40606-V08B SARS-CoV-2 S2 subunit,R&D Systems,Cat. # 10594-CV-100 Protein G Elution Buffer,Thermo Scientific,Cat. # 21004 IL21,Gibco,Cat. # PHC0211 R848,Invivogen,Cat.

(8) Evidence, detailed characterization and clinical context of complement activation in acute multisystem inflammatory syndrome in childrenScientific reportsNovember 17, 2022Sinkovits G, Schnur J, Hurler L, Kiszel P, Prohászka ZZ, Sík P, Kajdácsi E, Cervenak L, Maráczi V, Dávid M, et al.

(9) Children develop robust and sustained cross-reactive spike-specific immune responses to SARS-CoV-2 infectionNature immunologyJanuary 1, 2022Dowell AC, Butler MS, Jinks E, Tut G, Lancaster T, Sylla P, Begum J, Bruton R, Pearce H, Verma K, et al.recombinant spike S1 domain (catalog no. 10569-CV-100; R&D Systems) or spike S2 domain (catalog no. 10594-CV-100; R&D Systems) at a concentration of 500 μg ml−1 in PBS or PBS alone (mock). Samples were incubated at

(10) Humoral immune responses during SARS-CoV-2 mRNA vaccine administration in seropositive and seronegative individualsBMC medicineJuly 26, 2021Fraley E, LeMaster C, Geanes E, Banerjee D, Khanal S, Grundberg E, Selvarangan R, Bradley T.

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(1)

7/6/2022Cell Culture Testing of S2 Sub Unit Scott ScarneoHere we tested the S2 sub unit of the spike protein for immunogenicity against human macrophages. The protein was treated in cell culture and down stream inflammatory markers measured.

Spike S2 Subunit His-tag Protein

Spike S2 Subunit His-tag Protein

Spike S2 Subunit His-tag Protein

Recombinant SARS-CoV-2 Spike S2 Subunit His-tag Protein, CF from R&D Systems, a Bio-Techne Brand

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R&D Systems, a Bio-Techne Brand

Citations (10)

Reviews

Recombinant SARS-CoV-2 Spike S2 Subunit His-tag Protein, CF from R&D Systems, a Bio-Techne Brand

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