HDAC1, FLAG-Tag, His-Tag Recombinant 50051 from BPS Bioscience, Inc.

Product Specs
ItemHDAC1, FLAG-Tag, His-Tag Recombinant
CompanyBPS Bioscience, Inc.
Price $485.00Supplier Page View Company Product Page
Catalog Number50051
Size50 µg
Conjugate/TagC-terminal FLAG-tag, C-terminal His-tag
FormatAqueous buffer solution
Molecular Weight56 kDa
SpeciesHuman
Domain/Region/Terminusfull length
NCBI Full Gene Namehistone deacetylase 1
NCBI Gene AliasesRPD3L1, GON-10, RPD3, HD1, KDAC1
TypeProtein
Source/Expression SystemSf9 cells
insect
ApplicationsUseful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

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BPS Bioscience, Inc.

6405 Mira Mesa Blvd

Suite 100

San Diego, CA 92121

United States

Phone: 858-202-1401

Email: sales-team@bpsbioscience.com

Company Profile

Website: https://bpsbioscience.com/

(1) Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s DiseaseInternational Journal of Molecular SciencesMarch 30, 2026Mireia Toledano-Pinedo, Alicia Porro-Pérez, Linda Schäker-Hübner, Daniel Diez-Iriepa, Isabel Iriepa, Agata Siwek, Małgorzata Wolak, Grzegorz Satała, Andrzej J. Bojarski, Agata Doroz-Płonka, et al.and 10 µL of enzyme solution (human recombinant HDAC1 [BPS Bioscience (San Diego, CA, USA), Catalog# 50051]; HDAC6 [BPS Bioscience (San Diego, CA, USA), Catalog# 50006)] were added. In the case of o-aminoanilide

(2) Cellular Target Engagement and Dissociation Kinetics of Class I-Selective Histone Deacetylase (HDAC) InhibitorsInternational Journal of Molecular SciencesMarch 26, 2026Irina Honin, Zora Novakova, Felix Feller, Simon Schneider, Linda Schäker-Hübner, Cyril Barinka, Finn K. HansenGermany; #6055270). Next, 10 µL of human recombinant HDAC1 (BPS Bioscience Inc., San Diego, CA, USA, #50051), HDAC2 (BPS Bioscience Inc., San Diego, CA, USA; #50052) or HDAC3/NCoR (BPS Bioscience Inc., San Diego,

(3) Ortho -Hydroxyanilides: Slow-Acting, Selective Histone Deacetylase 1/2 Inhibitors Suitable for Photocaging ApplicationsACS Pharmacology & Translational ScienceDecember 12, 2025Irina Honin, Tao Sun, Nisha Setia, Linda Schäker-Hübner, Finn K. HansenWaltham, MA, USA). Then, 10 μL of human recombinant HDAC1 (BPS Bioscience Inc., San Diego, CA, USA, #50051), HDAC2 (BPS Bioscience Inc., San Diego, CA, USA, #50052), HDAC3 (BPS Bioscience Inc., San Diego, CA,

(4) Preclinical Characterization of SDFZ‐8, a Highly Potent HDAC1 Inhibitor, for Cancer ImmunotherapyMedComm (2020)December 1, 2025Yi Zhou, Jintong Du, Xue Li, Huajun Zhao, Junxin Xue, Yuchen Liu, Xinying Yang, Jinming Yu, Xuben Hou, Hao Fangaccording to our previous work [50]. In detail, the HeLa nuclear extract, HDAC1 (BPS BIOSCIENCE INC, 50051), HDAC2 (BPS BIOSCIENCE Inc; 50052), HDAC3/NCOR1 complex (BPS BIOSCIENCE Inc; 50003), HDAC4 (BPS BIOSCIENCE Inc

(5) TNG260 is a Small-Molecule CoREST Inhibitor that Sensitizes STK11-Mutant Tumors to Anti-PD-1 ImmunotherapyCancer ResearchOctober 15, 2025Leanne G. Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S. Patel, Ke Geng, Reshmee Bhattacharya, Gerald S. Falchook, Jonathan W. Goldman, Alexander I. Spira, Salman R. Punekar, et al.provided in Supplementary Table S1. Biochemical assay for deacetylase activity Recombinant HDAC1 (#50051), HDAC2 (#50002), and HDAC3/NCor2 (#50003) enzymes were purchased from BPS Bioscience. Assay reagents

(6) TNG260 Is a Small-Molecule CoREST Inhibitor That Sensitizes STK11-Mutant Tumors to Anti–PD-1 ImmunotherapyCancer ResAugust 29, 2025Leanne G. Ahronian, Soumyadip Sahu, Minjie Zhang, Ayushi S. Patel, Ke Geng, Reshmee Bhattacharya, Gerald S. Falchook, Jonathan W. Goldman, Alexander I. Spira, Salman R. Punekar, et al.provided in Supplementary Table S1. Biochemical assay for deacetylase activity Recombinant HDAC1 (#50051), HDAC2 (#50002), and HDAC3/NCor2 (#50003) enzymes were purchased from BPS Bioscience. Assay reagents

(7) Targeting neuroblastoma with hydroxamic acid based HDAC1 and HDAC2 inhibitors: Insights from in vitro and in vivo studiesInvestigational New DrugsJuly 10, 2025Padmini Pai, Yashaswini Reddy, Ipshita Das, Babu Santhi Venkidesh, Poonam Bhandari, Pallavi Rao, Srinivas Oruganti, Keshava Prasad, Manasa Gangadhar Shetty, Kapaettu Satyamoorthy, et al.Sigma Aldrich. Dulbecco’s Modified Eagle Medium (DMEM) was acquired from Himedia. HDAC1 (Catalogue No. 50051) and HDAC2 (Catalogue No. 50002) were purchased from BPS Biosciences. Chemical structure Two novel

(8) DCAF16-Based Covalent Molecular Glues for Targeted Protein Degradation of Histone DeacetylasesArch Pharm (Weinheim)July 9, 2025Tao Sun, Shiyang Zhai, Stephan Lepper, Beate König, Mateo Malenica, Irina Honin, Finn K. Hansenbuffer) [22] and 10 μL of enzyme solution were added. Human recombinant HDAC1 (BPS Bioscience, Catalog# 50051), HDAC2 (BPS Bioscience, Catalog# 50052), HDAC3/NcoR2 (BPS Bioscience, Catalog# 50003), or HDAC6 (BPS Bioscience

(9) Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expression of inflammation genesSci AdvMay 30, 2025Yi-Cheng Sin, Breann Abernathy, Zuo-Fei Yuan, Jason L. Heier, Justin E. Gonzalez, Laurie L. Parker, Douglas G. Mashek, Yue ChenHDAC3 (hs.Ri.HDAC3.13.1) was from Integrated DNA Technologies (Coralville, IA). Recombinant HDAC1 (50051), HDAC2 (50002), and HDAC3/NCOR2 (50003) were from BPS Bioscience (San Diego, CA). Sorbic acid–13C2

(10) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing PropertiesJournal of Medicinal ChemistryFebruary 27, 2025Daniel Stopper, Lukas Biermann, Paris R. Watson, Jingyu Li, Beate König, Matthew N. Gaynes, Lais Pessanha Pessanha de Carvalho, Jana Klose, Maria Hanl, Alexandra Hamacher, et al.were incubated with 10 μL of the respective human recombinant enzyme (HDAC1 (BPS Bioscience, Catalog# 50051); HDAC2 (BPS Bioscience, Catalog# 50052); HDAC3/NcoR2 (BPS Bioscience, Catalog# 50003); HDAC6 (BPS Bioscience,

(11) UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressorsNatureFebruary 12, 2025Megan J. R. Yeo, Olivia Zhang, Xiaowen Xie, Eunju Nam, N. Connor Payne, Pallavi M. Gosavi, Hui Si Kwok, Irtiza Iram, Ceejay Lee, Jiaming Li, et al.the kinetic parameter V/[E] calculation. HDAC1/2 activity assays Recombinant HDAC1 (BPS Bioscience 50051) or HDAC2 (BPS Bioscience 50002) were diluted to 6 nM (1.2×) into buffer containing 50 mM HEPES, pH

(12) Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitorsJ Enzyme Inhib Med ChemFebruary 6, 2025Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, et al.assay 384-well plates (Perkin Elmer, Cat. No. 6007279) were used. Human recombinant HDAC1 (Cat. No. 50051), HDAC2 (Cat. No. 50002), HDAC3 (Cat. No. 50003) and HDAC8 (Cat. No. 50008) were purchased from BPS

(13) Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase DegradersJournal of Medicinal ChemistryJanuary 23, 2025Felix Feller, Irina Honin, Martina Miranda, Heiko Weber, Svenja Henze, Maria Hanl, Finn K. HansenBudendorf, Swiss) were added, followed by 10 μL/well of enzyme solution. Human recombinant HDAC1 (Catalog# 50051, BPS Bioscience, San Diego, CA, USA), HDAC2 (Catalog# 50052, BPS Bioscience), HDAC4 (Catalog# 50004,

(14) Micro-scale screening of genetically modified Fusarium fujikuroi strain extends the apicidin familyNatural Products and BioprospectingDecember 1, 2024Alica Fischle, Mika Lutsch, Florian Hübner, Linda Schäker-Hübner, Lina Schürmann, Finn K. Hansen, Svetlana A. Kalinina(Z-Lys(Ac)-AMC[37], 21.43 µM in assay buffer) and 10 µL enzyme solution (HDAC1-BPS Bioscience, Catalog# 50051; HDAC2-BPS Bioscience, Catalog# 50052; HDAC3/NcoR2-BPS Bioscience, Catalog# 50003; HDAC6-BPS Bioscience,

(15) Aromatic Amino Acid Hydroxylases as Off-Targets of Histone Deacetylase InhibitorsACS Chemical NeuroscienceNovember 20, 2024Anne Baumann, Niklas Papenkordt, Dina Robaa, Peter D. Szigetvari, Anja Vogelmann, Franz Bracher, Wolfgang Sippl, Manfred Jung, Jan Haavikwere used. Assay volume was 60 μL, and 52 μL of human recombinant HDAC1 (BPS Bioscience, catalog no. 50051) in incubation buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 1 mg/mL BSA)

(16) Distribution and diversity of classical deacylases in bacteriaNature CommunicationsNovember 3, 2024Leonie G. Graf, Carlos Moreno-Yruela, Chuan Qin, Sabrina Schulze, Gottfried J. Palm, Ole Schmöker, Nancy Wang, Dianna M. Hocking, Leila Jebeli, Britta Girbardt, et al.PRO, TECAN). As controls human HsHDAC1 (full length, C-terminal His-FLAG-Tag, BPS Bioscience, cat no. 50051), HsHDAC6 (full length, N-terminal GST-Tag, Sigma-Aldrich, cat no.382180), HsHDAC7 (a.a. 518-end, N-terminal

(17) Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid TumorsJournal of medicinal chemistryAugust 22, 2024Zhao C, Zhang J, Zhou H, Setroikromo R, Poelarends GJ, Dekker FJ.Inhibition Assay Human recombinant C-terminal FLAG-tag, C-terminal His-tag HDAC1 (BPS Bioscience, Catalog#: 50051), Human recombinant C-terminal FLAG-tag HDAC2 (BPS Bioscience, Catalog#: 50052), human recombinant C-terminal

(18) Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule AgentsInternational Journal of Molecular SciencesJuly 9, 2024Elena Mariotto, Martina Canton, Chiara Marchioro, Andrea Brancale, Ernest Hamel, Katia Varani, Fabrizio Vincenzi, Tiziano De Ventura, Chiara Padroni, Giampietro Viola, et al.(BPS Bioscience, San Diego, CA, USA; Cat. # 50056), human recombinant HDAC1 (BPS Bioscience; Cat. # 50051), human recombinant HDAC8 (BPS Bioscience; Cat. # 50008), or 500 ng of human recombinant HDAC10 (BPS Bioscience

(19) Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin DeacetylationJournal of Medicinal ChemistryNovember 9, 2023Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A. Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z. Yesiloglu, Sebastian Hilscher, et al.the plates were incubated at 37 °C for 90 min. Human recombinant HDAC1 (BPS Bioscience, catalogue no. 50051), HDAC2 (BPS Bioscience, catalogue no. 50052), HDAC3/NcoR2 (BPS Bioscience, catalogue no. 50003), or

(20) Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6Journal of medicinal chemistryOctober 12, 2023König B, Watson PR, Reßing N, Cragin AD, Schäker-Hübner L, Christianson DW, Hansen FK.Then, 25 μL assay buffer and 10 μL enzyme solution (human recombinant HDAC1 (BPS Bioscience, Catalog# 50051); HDAC2 (BPS Bioscience, Catalog# 50052); HDAC3/NcoR2 (BPS Bioscience, Catalog# 50003); HDAC4 (BPS Bioscience,

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HDAC1, FLAG-Tag, His-Tag Recombinant

HDAC1, FLAG-tag, His-tag

HDAC1, FLAG-Tag, His-Tag Recombinant from BPS Bioscience, Inc.

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BPS Bioscience, Inc.

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HDAC1, FLAG-Tag, His-Tag Recombinant from BPS Bioscience, Inc.

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