HDAC6, GST-tag (Sf9-derived) Recombinant 50006 from BPS Bioscience, Inc.

Product Specs
ItemHDAC6, GST-tag (Sf9-derived) Recombinant
CompanyBPS Bioscience, Inc.
Price $530.00Supplier Page View Company Product Page
Catalog Number50006
Size50 µg
Conjugate/TagN-terminal GST-tag
FormatAqueous buffer solution
Molecular Weight159 kDa
SpeciesHuman
Domain/Region/Terminusfull length
NCBI Full Gene Namehistone deacetylase 6
NCBI Gene AliasesCPBHM, HD6, JM21, PPP1R90
TypeProtein
Source/Expression SystemSf9 cells
insect
ApplicationsUseful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

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BPS Bioscience, Inc.

6405 Mira Mesa Blvd

Suite 100

San Diego, CA 92121

United States

Phone: 858-202-1401

Email: sales-team@bpsbioscience.com

Company Profile

Website: https://bpsbioscience.com/

(1) Polyfunctionalized N-Arylsulfonyl Indoles: Identification of (E)-N-Hydroxy-3-{3-[(5-(3-(piperidin-1-yl)propoxy]-1H-indol-1-yl)sulfonyl]phenyl}acrylamide (MTP150) for the Epigenetic-based Therapy of Parkinson’s DiseaseInternational Journal of Molecular SciencesMarch 30, 2026Mireia Toledano-Pinedo, Alicia Porro-Pérez, Linda Schäker-Hübner, Daniel Diez-Iriepa, Isabel Iriepa, Agata Siwek, Małgorzata Wolak, Grzegorz Satała, Andrzej J. Bojarski, Agata Doroz-Płonka, et al.Bioscience (San Diego, CA, USA), Catalog# 50051]; HDAC6 [BPS Bioscience (San Diego, CA, USA), Catalog# 50006)] were added. In the case of o-aminoanilide and hydrazide-based inhibitors, which are known for their

(2) Preclinical Characterization of SDFZ‐8, a Highly Potent HDAC1 Inhibitor, for Cancer ImmunotherapyMedComm (2020)December 1, 2025Yi Zhou, Jintong Du, Xue Li, Huajun Zhao, Junxin Xue, Yuchen Liu, Xinying Yang, Jinming Yu, Xuben Hou, Hao Fang50003), HDAC4 (BPS BIOSCIENCE Inc; 50004), HDAC5 (BPS BIOSCIENCE Inc; 50005), HDAC6 (BPS BIOSCIENCE Inc; 50006), HDAC7 (BPS BIOSCIENCE Inc; 50007), HDAC8 (BPS BIOSCIENCE Inc; 50008), HDAC9 (BPS BIOSCIENCE Inc; 50009),

(3) Development and Characterization of the First Selective Class IIb Histone Deacetylase DegradersJournal of Medicinal ChemistryJuly 10, 2025Shiyang Zhai, Irina Honin, Linda Schäker-Hübner, Maria Hanl, Lukas Jacobi, Finn Dressler, Dominika Ewa Pieńkowska, Philipp König, Jan Gerhartz, Rabea Voget, et al.assay buffer) and 10 μL of human recombinant HDAC enzyme solution (HDAC6 - BPS Bioscience, Catalog# 50006) in assay buffer were added56. The total assay volume of 50 μL (max. 1% DMSO) was incubated at 37 °C

(4) Design and synthesis of thiazole-based hydroxamate histone deacetylase inhibitors with potent antitumor efficacy by inducing apoptosis, pyroptosis and cell cycle arrestSci RepJuly 9, 2025Zhijian Li, Huiran Qiu, Wenxia Lu, Namin Duan, Shule Fan, Rui Zhou, Xiangzhi Li, Hua Zhang, Ning Liu, Feifei YangCorporation. HDAC enzyme (HDAC1 Active motif 31504, HDAC2 BPS Bioscience 50002, HDAC6 BPS Bioscience 50006, HDAC8 Active motif 31566) solution was preincubated with varying concentrations of SAHA or the target

(5) DCAF16-Based Covalent Molecular Glues for Targeted Protein Degradation of Histone DeacetylasesArch Pharm (Weinheim)July 9, 2025Tao Sun, Shiyang Zhai, Stephan Lepper, Beate König, Mateo Malenica, Irina Honin, Finn K. Hansen(BPS Bioscience, Catalog# 50052), HDAC3/NcoR2 (BPS Bioscience, Catalog# 50003), or HDAC6 (BPS Bioscience, Catalog# 50006) was used. The total assay volume of 50 μL (HDAC2/3/6 max. 1% DMSO; HDAC1 max. 5% DMSO) was incubated

(6) Pharmacological manipulation of liver fibrosis progression using novel HDAC6 inhibitorsThe FEBS JournalMarch 14, 2025Maria Teresa Borrello, Dusan Ruzic, Hannah Paish, Eleanor Graham, Amy L. Collins, Rebecca Scott, Sam Higginbotham, Branko Radovic, Glyn Nelson, David Bulmer, et al.μL of 0.2 nm HDAC enzyme (human recombinant C‐ter‐GST‐HDAC 1 (H83‐30G)) and 0.2 nm N‐ter‐GST‐HDAC 6 (50006) (BPS Bioscience, San Diego, CA, USA) was added. The HDAC1 and HDAC6 deacetylase activity assays were

(7) Exploring Alternative Zinc-Binding Groups in Histone Deacetylase (HDAC) Inhibitors Uncovers DS-103 as a Potent Ethylhydrazide-Based HDAC Inhibitor with Chemosensitizing PropertiesJournal of Medicinal ChemistryFebruary 27, 2025Daniel Stopper, Lukas Biermann, Paris R. Watson, Jingyu Li, Beate König, Matthew N. Gaynes, Lais Pessanha Pessanha de Carvalho, Jana Klose, Maria Hanl, Alexandra Hamacher, et al.(BPS Bioscience, Catalog# 50052); HDAC3/NcoR2 (BPS Bioscience, Catalog# 50003); HDAC6 (BPS Bioscience, Catalog# 50006)) and diluted with 25 μL of assay buffer. Enzyme and inhibitor were preincubated for 60 min (HDAC1–3)

(8) Development of the First-in-Class FEM1B-Recruiting Histone Deacetylase DegradersJournal of Medicinal ChemistryJanuary 23, 2025Felix Feller, Irina Honin, Martina Miranda, Heiko Weber, Svenja Henze, Maria Hanl, Finn K. HansenHDAC2 (Catalog# 50052, BPS Bioscience), HDAC4 (Catalog# 50004, BPS Bioscience), or HDAC6 (Catalog# 50006, BPS Bioscience) were used. The total assay volume of 50 μL (max. 2% DMSO) was incubated at 37 °C for

(9) Design, Synthesis, and Biological Evaluation of HDAC Inhibitors Containing Natural Product-Inspired N-Linked 2-Acetylpyrrole CapMoleculesSeptember 30, 2024Han Zhang, Qianqian Shen, Zhu Hu, Pei-Qian Wu, Yi Chen, Jin-Xin Zhao, Jian-Min YueInhibition Assay HDAC1 (#50001, BPS, San Diego, USA), HDAC3 (#50003, BPS, San Diego, CA, USA) or HDAC6 (#50006, BPS, San Diego, USA), H3(1-21)K9Ac (#AS-64361, Anaspec, Fremont, CA, USA) substrate and test compounds

(10) Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin DeacetylationJournal of Medicinal ChemistryNovember 9, 2023Laura Sinatra, Anja Vogelmann, Florian Friedrich, Margarita A. Tararina, Emilia Neuwirt, Arianna Colcerasa, Philipp König, Lara Toy, Talha Z. Yesiloglu, Sebastian Hilscher, et al.50052), HDAC3/NcoR2 (BPS Bioscience, catalogue no. 50003), or HDAC6 (BPS Bioscience, catalogue no. 50006) was applied. Afterward, 50 μL of 0.4 mg/mL trypsin in trypsin buffer (50 mM Tris-HCl, pH 8.0, 100 mM

(11) Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6Journal of medicinal chemistryOctober 12, 2023König B, Watson PR, Reßing N, Cragin AD, Schäker-Hübner L, Christianson DW, Hansen FK.Bioscience, Catalog# 50003); HDAC4 (BPS Bioscience, Catalog# 50004); HDAC6 (BPS Bioscience, Catalog# 50006) were added. Enzyme and inhibitor were preincubated at 25 °C for 60 minutes. Afterwards, the fluorogenic

(12) Photocaged Histone Deacetylase Inhibitors as Prodrugs in Targeted Cancer TherapyPharmaceuticals (Basel, Switzerland)February 25, 2023Kraft FB, Hanl M, Feller F, Schäker-Hübner L, Hansen FK.USA, Catalog# 50051) or human recombinant HDAC6 (BPS Bioscience Inc., San Diego, CA, USA, Catalog# 50006) enzyme solution in assay buffer were added. The total assay volume (50 µL, 1% DMSO) was incubated at

(13) Solid-Phase Parallel Synthesis of Dual Histone Deacetylase-Cyclooxygenase InhibitorsMolecules (Basel, Switzerland)January 20, 2023Bachmann LM, Hanl M, Feller F, Sinatra L, Schöler A, Pietzsch J, Laube M, Hansen FK.10 µL of human recombinant HDAC1 (BPS Bioscience, Catalog# 50051) or HDAC6 (BPS Bioscience, Catalog# 50006) at 37 °C. After an incubation time of 90 min, 50 µL of 0.4 mg/mL trypsin in trypsin buffer (50 mM Tris-HCl,

(14) Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological EvaluationPharmaceuticsNovember 25, 2022Dusan Ruzic, Bernhard Ellinger, Nemanja Djokovic, Juan F. Santibanez, Sheraz Gul, Milan Beljkas, Ana Djuric, Arasu Ganesan, Aleksandar Pavic, Tatjana Srdic-Rajic, et al.recombinant C-ter-His-FLAG-HDAC1 (Catalog #50051), HDAC-3/NcoR2 (Catalog #50003), N-ter-GST-HDAC-6 (Catalog #50006), and C-terminal His-tag-HDAC8 (Catalog #50008) proteins were purchased from BPS Bioscience (San Diego,

(15) Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute LeukemiaJournal of Medicinal ChemistryNovember 24, 2022Nina Reßing, Julian Schliehe-Diecks, Paris R. Watson, Melf Sönnichsen, Abigail D. Cragin, Andrea Schöler, Jing Yang, Linda Schäker-Hübner, Arndt Borkhardt, David W. Christianson, et al.50052), HDAC3/NcoR2 (BPS Bioscience, Catalog# 50003) or full length HDAC6 (BPS Bioscience, Catalog# 50006) at 37 °C. After an incubation time of 90 min, 50 μL of 0.4 mg/mL trypsin in trypsin buffer (50 mM Tris-HCl,

(16) First Fluorescent Acetylspermidine Deacetylation Assay for HDAC10 Identifies Selective Inhibitors with Cellular Target Engagement**ChemBioChemJuly 19, 2022Daniel Herp, Johannes Ridinger, Dina Robaa, Stephen A. Shinsky, Karin Schmidtkunz, Talha Z. Yesiloglu, Theresa Bayer, Raphael R. Steimbach, Corey J. Herbstâ€Gervasoni, Annika Merz, et al.HDAC1 (BPS Bioscience, catalog no. 50051) and human recombinant HDAC6 (BPS Bioscience, catalog no. 50006) were used. Activity assays were performed in OptiPlateTM‐96 F black microplates (PerkinElmer). The

(17) Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs InhibitorsDrug Des Devel TherApril 11, 2022Suhua Wang, Siyuan Han, Weiyan Cheng, Ruoyang Miao, Shasha Li, Xin Tian, Quancheng KanMotif, 31504), HDAC2 (BPS bioscience, 50002), HDAC5 (BPS bioscience, 50005), HDAC6 (BPS bioscience, 50006), HDAC8 (Active Motif, 31566), HDAC11 (BPS bioscience, 50011), and compounds solution were dissolved

(18) Design, Synthesis, and Biological Evaluation of 2-Anilino-4-Triazolpyrimidine Derivatives as CDK4/HDACs InhibitorsDrug Design, Development and TherapyApril 11, 2022Suhua Wang, Siyuan Han, Weiyan Cheng, Ruoyang Miao, Shasha Li, Xin Tian, Quancheng KanMotif, 31504), HDAC2 (BPS bioscience, 50002), HDAC5 (BPS bioscience, 50005), HDAC6 (BPS bioscience, 50006), HDAC8 (Active Motif, 31566), HDAC11 (BPS bioscience, 50011), and compounds solution were dissolved

(19) Development of a NanoBRET assay to validate inhibitors of Sirt2-mediated lysine deacetylation and defatty-acylation that block prostate cancer cell migration†RSC Chemical BiologyApril 6, 2022A. Vogelmann et al.HDAC1 (BPS Bioscience, catalogue no. 50051) or human recombinant HDAC6 (BPS Bioscience, catalogue no. 50006) in incubation buffer (50 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 1 mg mL−1 BSA)

(20) Synthesis, Antiplasmodial, and Antileukemia Activity of Dihydroartemisinin–HDAC Inhibitor Hybrids as Multitarget DrugsPharmaceuticals (Basel)March 9, 2022Lukas von Bredow et al.Inc., San Diego, CA, USA, Catalog# 50051) or HDAC6 (BPS Bioscience Inc., San Diego, CA, USA, Catalog# 50006) at 37 °C. After an incubation time of 90 min, 50 µL of 0.4 mg/mL trypsin in trypsin buffer (50 mM Tris-HCl,

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HDAC6, GST-tag (Sf9-derived) Recombinant

HDAC6, GST-tag (Sf9-derived) Recombinant

HDAC6, GST-tag (Sf9-derived) Recombinant

HDAC6, GST-tag (Sf9-derived) Recombinant from BPS Bioscience, Inc.

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BPS Bioscience, Inc.

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HDAC6, GST-tag (Sf9-derived) Recombinant from BPS Bioscience, Inc.

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