HDAC8, His-Tag Recombinant 50008 from BPS Bioscience, Inc.

Product Specs
ItemHDAC8, His-Tag Recombinant
CompanyBPS Bioscience, Inc.
Price $460.00Supplier Page View Company Product Page
Catalog Number50008
Size50 µg
Conjugate/TagC-terminal His-tag
FormatAqueous buffer solution
Molecular Weight42.4 kDa
SpeciesHuman
Domain/Region/Terminusfull length
NCBI Full Gene Namehistone deacetylase 8
NCBI Gene AliasesMRXS6, WTS, CDLS5, KDAC8, HD8, CDA07, RPD3, HDACL1
TypeProtein
Source/Expression SystemSf9 cells
insect
ApplicationsUseful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling

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BPS Bioscience, Inc.

6405 Mira Mesa Blvd

Suite 100

San Diego, CA 92121

United States

Phone: 858-202-1401

Email: sales-team@bpsbioscience.com

Company Profile

Website: https://bpsbioscience.com/

(1) Preclinical Characterization of SDFZ‐8, a Highly Potent HDAC1 Inhibitor, for Cancer ImmunotherapyMedComm (2020)December 1, 2025Yi Zhou, Jintong Du, Xue Li, Huajun Zhao, Junxin Xue, Yuchen Liu, Xinying Yang, Jinming Yu, Xuben Hou, Hao Fang50005), HDAC6 (BPS BIOSCIENCE Inc; 50006), HDAC7 (BPS BIOSCIENCE Inc; 50007), HDAC8 (BPS BIOSCIENCE Inc; 50008), HDAC9 (BPS BIOSCIENCE Inc; 50009), HDAC10 (BPS BIOSCIENCE Inc; 50010), or HDAC11 (BPS BIOSCIENCE Inc;

(2) Discovery of novel biphenyl compounds bearing hydroxamic acid moiety as the first PD-L1/class I HDACs dual inhibitorsJ Enzyme Inhib Med ChemFebruary 6, 2025Dandan Yuan, Yali Gao, Lin Xia, Han Liu, Xingye Wu, Xueyan Ding, Yudan Huang, Changchun Deng, Jin Li, Wenqi Dai, et al.recombinant HDAC1 (Cat. No. 50051), HDAC2 (Cat. No. 50002), HDAC3 (Cat. No. 50003) and HDAC8 (Cat. No. 50008) were purchased from BPS Biosciences. SAHA (Cat. No. SML0061) was purchased from Sigma. The compounds

(3) Exploration of Hydrazide-Based HDAC8 PROTACs for the Treatment of Hematological Malignancies and Solid TumorsJournal of medicinal chemistryAugust 22, 2024Zhao C, Zhang J, Zhou H, Setroikromo R, Poelarends GJ, Dekker FJ.(BPS Bioscience, Catalog#: 50003) and human recombinant C-terminal His-tag HDAC8 (BPS Bioscience, Catalog#: 50008) were diluted in assay buffer (25 mM Tris-HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1

(4) Synthesis and Biological Evaluation of Novel 2-Aroyl Benzofuran-Based Hydroxamic Acids as Antimicrotubule AgentsInternational Journal of Molecular SciencesJuly 9, 2024Elena Mariotto, Martina Canton, Chiara Marchioro, Andrea Brancale, Ernest Hamel, Katia Varani, Fabrizio Vincenzi, Tiziano De Ventura, Chiara Padroni, Giampietro Viola, et al.human recombinant HDAC1 (BPS Bioscience; Cat. # 50051), human recombinant HDAC8 (BPS Bioscience; Cat. # 50008), or 500 ng of human recombinant HDAC10 (BPS Bioscience; Cat. # 50060) in an assay buffer containing

(5) Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological EvaluationPharmaceuticsNovember 25, 2022Dusan Ruzic, Bernhard Ellinger, Nemanja Djokovic, Juan F. Santibanez, Sheraz Gul, Milan Beljkas, Ana Djuric, Arasu Ganesan, Aleksandar Pavic, Tatjana Srdic-Rajic, et al.HDAC-3/NcoR2 (Catalog #50003), N-ter-GST-HDAC-6 (Catalog #50006), and C-terminal His-tag-HDAC8 (Catalog #50008) proteins were purchased from BPS Bioscience (San Diego, CA, USA). Trichostatin A (Sigma-Aldrich, St.

(6) Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in MiceJournal of Medicinal ChemistryFebruary 24, 2022Jawad B. Belayet, Sarah Beamish, Mizzanoor Rahaman, Samer Alanani, Rajdeep S. Virdi, David N. Frick, A. F. M. Towheedur Rahman, Joseph S. Ulicki, Sreya Biswas, Leggy A. Arnold, et al.HDAC2 (Catalogue #50002), HDAC3 (Catalogue #50051), HDAC6 (Catalogue #50046), and HDAC8 (Catalogue #50008). Each protein was diluted to the same concentration based on their calculated molar mass in “HDAC-Glo

(7) High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assaysSTAR ProtocolsMarch 4, 2021Carlos Moreno-Yruela, Christian A. OlsenN-terminal His-tag),Millipore,Cat#14-832 HDAC8 (full length with C-terminal His-tag),BPS Bioscience,Cat#50008 HDAC9 (aa 604–1066 with C-terminal His-tag),BPS Bioscience,Cat#50009 HDAC10 (aa 2–631 with N-terminal

(8) Hydroxamic acid-modified peptide microarrays for profiling isozyme-selective interactions and inhibition of histone deacetylasesNature communicationsJanuary 4, 2021Moreno-Yruela C, Bæk M, Vrsanova AE, Schulte C, Maric HM, Olsen CA.80%, activity ≥ 3000 pmol/min/µg), HDAC8 (full length, C-terminal His tag, BPS Bioscience, cat. #: 50008, lots 150714 and 161216, purity ≥ 90%, activity ≥ 300 NATURE COMMUNICATIONS | (2021)12:62 | https://doi.org/10.1038/s41467-020-20250-9

(9) A novel multistage antiplasmodial inhibitor targeting Plasmodium falciparum histone deacetylase 1Cell DiscoveryDecember 11, 2020Zhenghui Huang et al.LC-MS/MS. Human HDAC inhibition assay Human HDACs 1–3 (Cat# 50058, 5002, 50003), 6 (Cat# 50046), and 8 (Cat# 50008) and Sirt 2 (Cat# 50013) were purchased from BPS Bioscience. SAHA and suramin were used as positive

(10) Natural HDAC-1/8 inhibitor baicalein exerts therapeutic effect in CBF-AMLClinical and translational medicineAugust 1, 2020Yu X, Li H, Hu P, Qing Y, Wang X, Zhu M, Wang H, Wang Z, Xu J, Guo Q, et al.BPS Bioscience, California, USA) were K379‐382 (RHKK(Ac)AMC) residues of p53. The substrate of HDAC‐8 (#50008, BPS Bioscience, California, USA) was p53‐K379‐K382(RHK(Ac)K(Ac)AMC). The deacetylation of the substrates

(11) Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 InhibitorsChemMedChemJuly 3, 2020Michael Morgen et al.HDAC1 cat. #50051; HDAC2 cat. #50002; HDAC3/NcoR2 complex cat. #50003; HDAC6 cat. #50006; HDAC8 cat. #50008). The assay was carried out in a 384‐well plate (4512, Corning) format according to the manufacturer's

(12) Design and synthesis of diazine-based panobinostat analogues for HDAC8 inhibitionBeilstein Journal of Organic ChemistryApril 7, 2020Sivaraman Balasubramaniam, Sajith Vijayan, Liam V Goldman, Xavier A May, Kyra Dodson, Sweta Adhikari, Fatima Rivas, Davita L Watkins, Shana V StoddardInformation File 1. HDAC8 enzymatic activity assay A fluorogenic assay (BPS Bioscience, catalog # 50008) was performed to evaluate the inhibition potential of the designed inhibitors. The assay was carried

(13) HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl LysineACS Chemical BiologyOctober 21, 2016Pornpun Aramsangtienchai, Nicole A. Spiegelman, Bin He, Seth P. Miller, Lunzhi Dai, Yingming Zhao, Hening Linenzyme. METHODS Material and reagents Recombinant human HDAC8 from Sf9 cells was purchased from BPS Bioscience (cat#50008). HDAC inhibitors (PCI-34051, SAHA, Panobinostat, and Mocetinostat) were purchased from Selleckchem.com

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HDAC8, His-Tag Recombinant

HDAC8, His-Tag Recombinant

HDAC8, His-tag

HDAC8, His-Tag Recombinant

HDAC8, His-Tag Recombinant from BPS Bioscience, Inc.

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BPS Bioscience, Inc.

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HDAC8, His-Tag Recombinant from BPS Bioscience, Inc.

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