Recombinant Human ACE2 Protein 230-30165 from RayBiotech

Product Specs
ItemRecombinant Human ACE2 Protein
CompanyRayBiotech
Price $322.00Supplier Page View Company Product Page
Catalog Number230-30165
Size100 µg, 500 µg, 1000 µg
Molecule NameACE2, Angiotensin-converting enzyme 2, ACE-related carboxypeptidase, ACEH, Metalloprotease MPROT15
Research AreaAngiogenesis, Antibody Drug Development, Drug Antibody (DA) Detection, Inflammation, Protein Therapeutics, Receptor-Ligand Binding
SpeciesHuman
Molecular WeightRecombinant protein product has a calculated molecular mass of ∼83 kDa. Due to the abundant glycosylation, it migrates as approximately 90 kDa protein bands in SDS-PAGE under DTT, beta-mercaptoethanol reducing conditions. See deglycosylation analysis image below
FormatLiquid
ConcentrationLot specific (see the label on the vial), determined by BCA protein assay
Source/Expression SystemHEK293 cells
Purity>95 %
Conjugate/TagC-terminal his-tag
NCBI Gene AliasesACEH
NCBI Full Gene Nameangiotensin converting enzyme 2
ApplicationsWB, ELISA

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RayBiotech

3607 Parkway Lane, Ste. 200

Peachtree Corners, Georgia 30092

United States

Phone: 770-729-2992
888-494-8555

Company Profile

Website: www.RayBiotech.com

(1) The LDL receptor related protein 1 (LRP1) facilitates ACE2-mediated endocytosis of SARS-CoV2 spike protein-containing pseudovirionsJournal of Biological ChemistryMay 9, 2025Mashhood M. Wani, Joanna M. Cooper, Mary Migliorini, Dudley K. Stricklandhuman angiotensin-converting enzyme two ectodomain (Gln18 – Ser740) was purchased from RayBiotech (230–30165). LRP1 was purified from human placenta as described (42). Soluble forms of the VLDL receptor containing

(2) N-glycosylation of the SARS-CoV-2 spike protein at Asn331 and Asn343 is involved in spike-ACE2 binding, virus entry, and regulation of IL-6Microbiology and immunologyMay 1, 2024Das T, Luo S, Tang H, Fang J, Mao Y, Yen HH, Dash S, Shajahan A, Pepi L, Huang S, et al.230–30163) Nucleocapsid,SARS-CoV-2,QHD43423,Met1-Ala419,HEK293,RayBiotech (cat. 230–30164) ACE2,Human,Q9BYF1,Gln18-Ser740,HEK293,RayBiotech (cat. 230–30165) p24,HIV,Q9WMW5,Ser5-Cys207,E. coli,RayBiotech (cat. 230–00505) "S1 Subunit, RBD, L452R/T478K mutant",SARS-CoV-2,QHD43416,Arg319-Phe541,HEK293,RayBiotech

(3) The SpACE-CCM: A facile and versatile cell culture medium-based biosensor for detection of SARS-CoV-2 spike-ACE2 interactionBiosensors & bioelectronicsMay 1, 2023Ham Y, Cho NC, Kim D, Kim JH, Jo MJ, Jeong MS, Pak BY, Lee S, Lee MK, Chi SW, et al.spike RBD (aa 319–541, Raybiotech, GA, USA, Cat.# 230–30162) or ACE2 (aa 18–740, Raybiotech, Cat.# 230–30165) proteins. 2.7 Long-term storage evaluation of the SpACE-CCM biosensor To evaluate the stability of

(4) A potent and broad neutralization of SARS-CoV-2 variants of concern by DARPinsNature Chemical BiologyMarch 1, 2023Vikas Chonira, Young D. Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G. Casner, Darcy R. Harris, Adam S. Olia, Tyler Stephens, et al.in each well was quantified using BioFx TMB. For preparation of hACE2-HRP, hACE2 (Raybiotech, Cat #230–30165, 1.76 mg/mL) was first biotinylated as described above and then incubated with an equal molar amount

(5) Targeting SARS-CoV-2 by synthetic dual-acting thiol compounds that inhibit Spike/ACE2 interaction and viral protein productionFASEB journal : official publication of the Federation of American Societies for Experimental BiologyFebruary 1, 2023Fraternale A, De Angelis M, De Santis R, Amatore D, Masini S, Monittola F, Menotta M, Biancucci F, Bartoccini F, Retini M, et al.

(6) Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cellsFrontiers in neuroscienceJanuary 1, 2023McQuaid C, Solorzano A, Dickerson I, Deane R.microscope (Obrekochen, Germany). ACE2 binding to SP Recombinant human ACE2 (HEC 293 cells; cat# 230-30165), RayBiotech Life, 663276971Inc663276971RCRevathi Chandrasekar663276971-944626917Please note that the

(7) Development of a Biosensor Based on Angiotensin‐Converting Enzyme II for Severe Acute Respiratory Syndrome Coronavirus 2 Detection in Human SalivaFront Sens (Lausanne)August 22, 2022Geisianny Moreira, Lisseth Casso-Hartmann, Shoumen Palit Austin Datta, Delphine Dean, Eric McLamore, Diana Vanegashuman ACE2 (C-terminal 6X his-tag; HEK293 cells expression system; 83 kDa; >95% purity; catalog number: 230–30165) was purchased from RayBiotech, Inc. (Norcross, GA, United States). EZ-Link™ NHS-PEG4-Biotin, No-Weigh™ Format

(8) A tethered ligand assay to probe SARS-CoV-2:ACE2 interactionsProceedings of the National Academy of SciencesApril 5, 2022Magnus S. Bauer et al.recombinant human ACE2 (GLN18-SER740, C-terminal His-tag) from RayBiotech (âˆ¼3.8 ÂµM in measurement buffer, # 230-30165-100) was flushed into the flow cell and briefly incubated before the measurement. Supplementary Material Supplementary

(9) Monoclonal Antibodies Capable of Binding SARS-CoV-2 Spike Protein Receptor Binding Motif Specifically Prevent GM-CSF Induction.bioRxivMarch 31, 2022Xiaoling Qiang, Shu Zhu, Jianhua Li, Ping Wang, Kevin J. Tracey, Haichao Wangwas obtained from two different commercial sources, Biolegend (Cat. # 7920008) and Raybiotech (Cat. # 230–30165). Cell culture Human blood was purchased from the New York Blood Center (Long Island City, NY, USA),

(10) Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2Nature communicationsJanuary 20, 2022El-Shennawy L, Hoffmann AD, Dashzeveg NK, McAndrews KM, Mehl PJ, Cornish D, Yu Z, Tokars VL, Nicolaescu V, Tomatsidou A, et al.cell culture-derived EVs”, resuspended in PBS, mixed with 2 µg recombinant ACE2 protein (RayBiotech 230-30165-100), and subjected to density gradient fractionation as in ref. 73. Resuspended pellets were loaded into

(11) Host Cell Glycocalyx Remodeling Reveals SARS-CoV-2 Spike Protein Glycomic Binding SitesFrontiers in molecular biosciencesJanuary 1, 2022Sheng Y, Vinjamuri A, Alvarez MRS, Xie Y, McGrath M, Chen S, Barboza M, Frieman M, Lebrilla CB.Information Recombinant human angiotensin-converting enzyme 2 (ACE2) (RayBiotech, Georgia, Product Number 230-30165), SARS-CoV-2 spike protein S1 Subunit RBD (Arg319-Phe541) (RayBiotech, Georgia, Product Number 230-30162)

(12) Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cellsScientific reportsNovember 12, 2021Caohuy H, Eidelman O, Chen T, Liu S, Yang Q, Bera A, Walton NI, Wang TT, Pollard HB.were obtained as follows: Recombinant (exodomain) Human Angiotensin Converting Enzyme 2 (ACE2) (Cat # 230-30165; lot 04U06020TW) was purchased from RayBiotech (Peachtree Corners, GA, 30092). Human ACE2 Biotinylated

(13) Directed evolution of potent neutralizing nanobodies against SARS-CoV-2 using CDR-swapping mutagenesisCell chemical biologySeptember 16, 2021Zupancic JM, Desai AA, Schardt JS, Pornnoppadol G, Makowski EK, Smith MD, Kennedy AA, Garcia de Mattos Barbosa M, Cascalho M, Lanigan TM, et al.first pre-incubated with soluble nanobodies/antibodies in the bivalent format or ACE2 (RayBiotech, 230-30165) over a range of concentrations (0.05, 0.5, 5, 50 and 500 nM) for 2 h at room temperature with mild

(14) Molecular Masks for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus EntryInternational journal of molecular sciencesAugust 20, 2021Shukla SP, Cho KB, Rustagi V, Gao X, Fu X, Zhang SX, Guo B, Udugamasooriya DG.100 µL/well of recombinant human angiotensin-converting enzyme 2 (ACE2) (His-tag) (RayBiotech, Cat# 230-30165-100, Peachtree Corners, GA, USA) protein (1 µg/mL in TBS) was added to nickel coated white 96-well plates

(15) Engineered Multivalent Nanobodies Potently and Broadly Neutralize SARS‐CoV‐2 VariantsAdvanced TherapeuticsAugust 2, 2021Jennifer M. Zupancic, John S. Schardt, Alec A. Desai, Emily K. Makowski, Matthew D. Smith, Ghasidit Pornnoppadol, Mayara Garcia de Mattos Barbosa, Marilia Cascalho, Thomas M. Lanigan, Peter M. Tessiermild agitation with varying concentrations (500, 50, 5, 0.5, and 0.05 nm) of soluble ACE2 (RayBiotech, 230‐30165), nanobody‐Fc fusion protein, or mAb. After 2 h, 1 × 105 yeast cells displaying VHH‐72 were added to

(16) Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiencyCell reports. MedicineJanuary 19, 2021Honjo K, Russell RM, Li R, Liu W, Stoltz R, Tabengwa EM, Hua Y, Prichard L, Kornbrust AN, Sterrett S, et al.Avi-tag,"Brouwer et al., Produced In House",PMID: 32540902 Recombinant human ACE2,Raybiotech,Cat# 230-30165 Recombinant SARS-CoV-2 S1 subunit (RBD),Raybiotech,Cat# 230-30162 DMEM,ThermoFisher,Cat# 10566024 "Characterized

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Recombinant Human ACE2 Protein from RayBiotech

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Recombinant Human ACE2 Protein from RayBiotech

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