Human ACE2 / ACEH Protein, Fc Tag (MALS verified) AC2-H5257-1MG from ACROBiosystems

Product Specs
ItemHuman ACE2 / ACEH Protein, Fc Tag (MALS verified)
CompanyACROBiosystems
Price $3,010.00Supplier Page View Company Product Page
Catalog NumberAC2-H5257-1MG
Size1mg
Conjugate/TagC-Fc
FormatPowder, 50 mM Tris, 150 mM NaCl, Arginine, pH7.5
Molecular Weight110.0 kDa
SpeciesHuman
Molecule NameACE2
Source/Expression SystemHEK293
Purity95%
NCBI Full Gene Nameangiotensin converting enzyme 2
NCBI Gene AliasesACEH
Domain/Region/TerminusGln 18 - Ser 740
Storage-20℃

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ACROBiosystems

1 Innovation Way

Newark, DE 19711

United States

Phone: +1 800-810-0816
Fax: +1 888-377-6111

Email: order@acrobiosystems.com

Company Profile

Website: http://www.acrobiosystems.com/

(1) Neutralisation resistance of SARS-CoV-2 spike-variants is primarily mediated by synergistic receptor binding domain substitutionsEmerging Microbes & InfectionsDecember 31, 2024Long V. Pham, Alexander P. Underwood, Alekxander Binderup, Ulrik Fahnøe, Carlota Fernandez-Antunez, Blanca Lopez-Mendez, Line Abildgaard Ryberg, Andrea Galli, Christina Sølund, Nina Weis, et al.reference for subtraction of systematic instrumental drift. Human ACE2 Fc tagged (Acro Biosystems, AC2-H5257) at 3 nM or 15 nM was then captured on Fc2 using contact times of 24 s or 48 s and a 5 μl/min flow rate

(2) Micro-second time-resolved X-ray single-molecule internal motions of SARS-CoV-2 spike variantsBiochemistry and Biophysics ReportsJuly 1, 2024Daisuke Sasaki, Tatsuya Arai, Yue Yang, Masahiro Kuramochi, Wakako Furuyama, Asuka Nanbo, Hiroshi Sekiguchi, Nobuhiro Morone, Kazuhiro Mio, Yuji C. Sasakiexperiment, spike variants were adsorbed on the substrate as in the previous experiment, ACE2 receptor (#AC2-H5257, ACRO Biosystems, 50 mg/0.1 mL) was reacted with the spike-variant-adsorbed substrate for 1 h, and then

(3) A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variantsAntibody TherapeuticsMay 3, 2024Marisa L Yang, Tom Z Yuan, Kara Y Chan, Lin Ding, Zhen Han, Hector Franco, Carson Holliday, Shruthi Kannan, Edgar Davidson, Benjamin J Doranz, et al.1% BSA. 10 nM SARS-CoV-2 S RBD BA.4/5 (Acro SPD-C522r) was injected, followed by 10 nM ACE2-Fc (Acro AC2-H5257). Data were analyzed in Carterra’s Kinetics Tool software. Alanine scanning mutagenesis Alanine scanning

(4) Semisynthesis of homogeneous spike RBD glycoforms from SARS-CoV-2 for profiling the correlations between glycan composition and functionNational Science ReviewJanuary 22, 2024Farong Ye, Cheng Li, Feng-Liang Liu, Xinliang Liu, Peng Xu, Rong-Hua Luo, Wenping Song, Yong-Tang Zheng, Tianlei Ying, Biao Yu, et al.RBD: ACROBiosystems, Arg319–Lys537 with His Tag, cat. no. SPD-C52H1. ACE2: ACROBiosystems, cat. no. AC2-H5257.

(5) Circularized Nanodiscs for Multivalent Mosaic Display of SARS-CoV-2 Spike Protein AntigensVaccinesOctober 28, 2023Mabrouk MT, Zidan AA, Aly N, Mohammed MT, Ghantous F, Seaman MS, Lovell JF, Nasr ML.Subsequently, the membrane was incubated with a 1000-fold diluted solution of human ACE2-Fc Tag (Cat # AC2-H5257 from ACRO Biosystems, Newark, DE, USA) for 1 h at RT. The membrane was washed with PBS for 5 min, repeated

(6) Peptide foldamer-based inhibitors of the SARS-CoV-2 S protein-human ACE2 interactionJ Enzyme Inhib Med ChemAugust 22, 2023Violeta Marković, Jeelan Basha Shaik, Katarzyna Ożga, Agnieszka Ciesiołkiewicz, Juan Lizandra Perez, Ewa Rudzińska-Szostak, Łukasz Berlicki6HIS-XL665 (CisBio #61HISXLA), proteins: Human ACE2/ACEH Protein, Fc Tag (MALS verified) (AcroBioSystem #AC2-H5257) and SARS-CoV-2 (COVID-19) S protein RBD, His Tag (MALSverified) (AcroBioSystem #SPD-C52H3) and PPI

(7) Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2Nature communicationsJune 16, 2023Gaynor KU, Vaysburd M, Harman MAJ, Albecka A, Jeffrey P, Beswick P, Papa G, Chen L, Mallery D, McGuinness B, et al.tagged Spike Trimer (pCOV54) at 0.20 nM was incubated with 0.20 nM of hACE2 Fc-fusion (ACROBiosystems - AC2-H5257) and a duplicate titration of monomeric or multimeric untagged Bicycles. Finally, 20 µg/mL Nickel-chelate

(8) Neutrophil elastase decreases SARS-CoV-2 spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomain from the epithelial surfaceThe Journal of biological chemistryJune 1, 2023Kummarapurugu AB, Hawkridge AM, Ma J, Osei S, Martin RK, Zheng S, Voynow JA.tested in vitro using recombinant human ACE-2 protein with Fc-tag at the C terminus (catalog number AC2-H5257, Acro BIOSYSTEMS) or SARS-CoV-2 spike protein, His tag, active trimer (catalog number SPN-C52H8, Acro

(9) Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variantsAntibody TherapeuticsJanuary 20, 2023Neil M Bodie, Rina Hashimoto, David Connolly, Jennifer Chu, Kazuo Takayama, Bruce D Uhalassay (Acro Biosystems) **Omicron variant B.1.1.529, 01 November 2022 ***Human ACE2, Fc Tag (Cat. No. AC2-H5257, ACRO Biosystems) ****Human ACE-2 Fc fusion protein (Cat. No. Z03516, Genscript)

(10) Arsenal of nanobodies shows broad-spectrum neutralization against SARS-CoV-2 variants of concern in vitro and in vivo in hamster modelsCommunications biologySeptember 9, 2022Rossotti MA, van Faassen H, Tran AT, Sheff J, Sandhu JK, Duque D, Hewitt M, Wen X, Bavananthasivam J, Beitari S, et al.2-fold serially diluted ACE2-Fc (human ACE2 fused to human IgG1 Fc; ACROBiosystems, Newark, DE, Cat#AC2-H5257) in PBSTC (PBS/0.2% casein/0.1% Tween 20). Wells were washed five times and incubated for 1 h with 1

(11) Functional profiling of Covid 19 vaccine candidate by flow virometryVaccineSeptember 2, 2022Prout A, Rustandi RR, Tubbs C, Winters MA, McKenna P, Vlasak J.Catalog number,Manufacturer,Immunogen,Neutralizing,Species human ACE2-Fc (AC2-H5257),Acro Biosystems,N/A,Yes,Human AM91337,Active Motif,S1,No,Human AM91339,Active Motif,S1,No,Human AM91341,Active

(12) RelCoVaxÂ®, a two antigen subunit protein vaccine candidate against SARS-CoV-2 induces strong immune responses in miceVaccineJuly 30, 2022Abhishek Phatarphekar, G.E.C. Vidyadhar Reddy, Abhiram Gokhale, Gopala Karanam, Pushpa Kuchroo, Ketaki Shinde, Girish Masand, Shyam Pagare, Nilesh Khadpe, Sangita S. Pai, et al.determined for 3 individual batches of purified RBD protein. Human ACE2 with Fc tag (Acro Biosystems, AC2-H5257) was captured on the CM5 chip using a running buffer comprising of 10 mM HEPES pH 7.2, 150 mM NaCl and

(13) Egg-Derived Anti-SARS-CoV-2 Immunoglobulin Y (IgY) With Broad Variant Activity as Intranasal Prophylaxis Against COVID-19Frontiers in ImmunologyJune 1, 2022Lyn R. Frumkin et al.then measured on a Biacore T200 instrument, using Fc-tagged hACE2 receptor protein (ACROBiosystems AC2-H5257); see Supplementary Methods . 2.3 Hen Immunization and IgY Purification and Characterization Nine

(14) The SARS-CoV-2 spike protein binds and modulates estrogen receptorsbioRxiv : the preprint server for biologyMay 23, 2022Solis O, Beccari AR, Iaconis D, Talarico C, Ruiz-Bedoya CA, Nwachukwu JC, Cimini A, Castelli V, Bertini R, Montopoli M, et al.mM MgCl2, 0.1 mM EDTA, pH 7.4) and incubated with human ACE2 Fc Tag (0.2 μg/well) (Acro Biosystems, #AC2-H5257) in incubation buffer (50 mM Tris, 5 mM MgCl2, 0.1 mM EDTA, 2% BSA, pH 7.4) for 60 minutes with gentle

(15) Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasmaLife science allianceFebruary 1, 2022Schneider MM, Emmenegger M, Xu CK, Condado Morales I, Meisl G, Turelli P, Zografou C, Zimmermann MR, Frey BM, Fiedler S, et al.patients who signed an informed consent. Reagents SARS-CoV-2 RBD (SPD-C52H3), ACE2 receptor protein (AC2-H5257), and SARS-CoV-2 spike S1 protein (S1N-C42H4) were purchased from SinoBio and SARS-CoV-2 spike S2 protein

(16) GlycoGrip: Cell Surface-Inspired Universal Sensor for BetacoronavirusesACS Central ScienceJanuary 26, 2022Sang Hoon Kim, Fiona L. Kearns, Mia A. Rosenfeld, Lorenzo Casalino, Micah J. Papanikolas, Carlos Simmerling, Rommie E. Amaro, Ronit FreemanSARS-CoV-2 Delta (B.1.617.2) spike (10878-CV-100) were purchased from R&D systems. Fc tagged human ACE2 (AC2-H5257) were purchased from Acro Biosystems. Streptavidin modified BLI biosensor tips (18-5019) and antihuman

(17) SARS-CoV-2 spike binding to ACE2 is stronger and longer ranged due to glycan interactionBiophysical journalJanuary 4, 2022Huang Y, Harris BS, Minami SA, Jung S, Shah PS, Nandi S, McDonald KA, Faller R.the ACE2 and RBD using the gmx energy command (54). Experiments Protein deglycosylation ACE2-Fc (AC2-H5257; Acro Biosystems, Newark, DE) and RBD (40592-V08B; Sino Biological, Chesterbrook, PA) deglycosylation

(18) Non-propagative human parainfluenza virus type 2 nasal vaccine robustly protects the upper and lower airways against SARS-CoV-2iScienceDecember 17, 2021Ohtsuka J, Imai M, Fukumura M, Maeda M, Eguchi A, Ono R, Maemura T, Ito M, Yamayoshi S, Kataoka Y, et al.#40591-V02H SARS-CoV-2 Spike Protein RBD,Sino Biological Inc.,Cat #40592-V02H Human ACE2 Protein,AcroBiosystems,Cat #AC2-H5257 Dako REAL EnVision Detection System,Dako,Cat #K5007 ,, Critical commercial assays,Critical commercial

(19) Lyophilized, thermostable Spike or RBD immunogenic liposomes induce protective immunity against SARS-CoV-2 in miceScience advancesDecember 3, 2021Mabrouk MT, Chiem K, Rujas E, Huang WC, Jahagirdar D, Quinn B, Surendran Nair M, Nissly RH, Cavener VS, Boyle NR, et al.min at RT, followed by incubating with 1000× diluted human ACE2-Fc Tag (ACROBiosystems, catalog no. AC2-H5257) for 1 hour at RT. The membrane was washed with PBS for 5 min twice and then incubated with horseradish

(20) Picomolar inhibition of SARS-CoV-2 variants of concern by an engineered ACE2-IgG4-Fc fusion proteinAntiviral ResearchDecember 1, 2021Hristo L. Svilenov et al.commercially available ACE2-Fc proteins obtained from Genscript (Cat.No. Z03484-1) and Acrobiosystems (Cat.No. AC2-H5257) were used as reference. 2.8 Determination of binding affinity to spike protein RBD using surface plasmon resonance

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Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

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Human ACE2 / ACEH Protein, Fc Tag (MALS verified) from ACROBiosystems

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Human ACE2 / ACEH Protein, Fc Tag (MALS verified) from ACROBiosystems

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