Human TMPRSS2 Protein (Activity Verified) (Yeast) CSB-YP023924HU from CUSABIO Technology LLC

Product Specs
ItemHuman TMPRSS2 Protein (Activity Verified) (Yeast)
CompanyCUSABIO Technology LLC
Price $306.00Supplier Page View Company Product Page
Catalog NumberCSB-YP023924HU
NCBI Full Gene Nametransmembrane serine protease 2
StorageThe shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃
Molecule NameTMPRSS2
FormatIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0., Liquid or Lyophilized powder
ActivityRecombinant Human TMPRSS2 His tag protein (CSB-YP023924HU) enzyme activity is measured by its ability to cleave fluorogenic peptide substrate(Boc-Gln-Ala-Arg-AMC), The Km is 21.93µM.
Measured by Camostat Mesylate inhibit ratio on TMPRSS2 (CSB-YP023924HU), which can cleave fluorogenic peptide substrate (Boc-Gln-Ala-Arg-AMC). The Camostat Mesylate inhibit EC50 is 0.03347-0.07945µM
Research AreaCancer
NCBI Gene AliasesPRSS10
Domain/Region/Terminus106-492aa, Partial
Gene NameTMPRSS2
Source/Expression SystemYeast
SpeciesHomo sapiens (Human)
Molecular Weight44.8 kDa
PurityGreater than 85% as determined by SDS-PAGE
Conjugate/TagN-terminal 6xHis-tagged
Size20ug

Sequence

WKFMGSKCSN SGIECDSSGT CINPSNWCDG VSHCPGGEDE NRCVRLYGPN FILQVYSSQR KSWHPVCQDD WNENYGRAAC RDMGYKNNFY SSQGIVDDSG STSFMKLNTS AGNVDIYKKL YHSDACSSKA VVSLRCIACG VNLNSSRQSR IVGGESALPG AWPWQVSLHV QNVHVCGGSI ITPEWIVTAA HCVEKPLNNP WHWTAFAGIL RQSFMFYGAG YQVEKVISHP NYDSKTKNND IALMKLQKPL TFNDLVKPVC LPNPGMMLQP EQLCWISGWG ATEEKGKTSE VLNAAKVLLI ETQRCNSRYV YDNLITPAMI CAGFLQGNVD SCQGDSGGPL VTSKNNIWWL IGDTSWGSGC AKAYRPGVYG NVMVFTDWIY RQMRADG

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CUSABIO Technology LLC

7707 Fannin St.

Ste 200-V126

Houston, TX 77054

United States

Phone: 301-363-4651

Email: support@cusabio.com

Company Profile

Website: www.cusabio.com

(1) Simulations and active learning enable efficient identification of an experimentally-validated broad coronavirus inhibitorNat CommunJuly 29, 2025Katarina Elez, Tim Hempel, Jonathan H. Shrimp, Nicole Moor, Lluís Raich, Cheila Rocha, Robin Winter, Tuan Le, Stefan Pöhlmann, Markus Hoffmann, et al.TMPRSS2 protein expressed from yeast (human TMPRSS2 residues 106492, N-terminal 6x His-tag) (cat. # CSB-YP023924HU) was acquired from Cusabio. The fluorogenic peptide substrate, Boc-QAR-AMC·HCl was obtained from Bachem

(2) From N-0385 to N-0920: Unveiling a Host-Directed Protease Inhibitor with Picomolar Antiviral Efficacy against Prevalent SARS-CoV-2 VariantsJournal of Medicinal ChemistryApril 10, 2025Gabriel Lemieux, Jimena Pérez-Vargas, Antoine Désilets, Malihe Hassanzadeh, Connor A. H. Thompson, Alice Gravel-Trudeau, Alexandre Joushomme, Siobhan Ennis, Ivan Villanueva, Étienne Marouseau, et al.conditions). First, we assessed TMPRSS2 inhibition in vitro using an enzyme preparation from Cusabio (CSB-YP023924HU) and a fluorogenic substrate to monitor TMPRSS2 proteolytic activity (Figure 2, left panel, data available

(3) Notes on AEMS methods development for high throughput experimentation in drug discoverySLAS TechnologyDecember 4, 2024Meghav Verma, Nate Hoxie, John Janiszewski, Charles Bonney, Matthew D. Hall, Sam Michael, Tom Covey, Jonathan H. ShrimpTMPRSS2 protein expressed from yeast (human TMPRSS2 residues 106–492, N- terminal 6× His-tag) (cat. # CSB-YP023924HU) was acquired from Cusabio. The fluorogenic peptide substrate, Boc-QAR- AMC. HCl was obtained from Bachem

(4) The Proteolytic Activity of Neutrophil-Derived Serine Proteases Bound to the Cell Surface Arming Lung Epithelial Cells for Viral DefenseMolecules (Basel, Switzerland)September 19, 2024Assylbekova A, Allayarova M, Konysbekova M, Bekturgan A, Makhanova A, Brown S, Grzegorzek N, Kalbacher H, Kalendar R, Burster T.addition of CaCl2 to a final concentration of 1.2 mM, or recombinant human TMPRSS2 (4 μg/mL, Cat. No. CSB-YP023924HU, Batch No. DA0471a3g001, BIOZOL, CUSABIO Technology, LLC, TX, USA) was incubated with 200 μg/mL peptide

(5) Small molecule in situ resin capture provides a compound first approach to natural product discoveryNature CommunicationsJune 19, 2024Alexander Bogdanov, Mariam N. Salib, Alexander B. Chase, Heinz Hammerlindl, Mitchell N. Muskat, Stephanie Luedtke, Elany Barbosa da Silva, Anthony J. O’Donoghue, Lani F. Wu, Steven J. Altschuler, et al.purchased from Acro Biosystems (PAE-C518), and human TMPRSS2 was purchased from Cusabio Technology (CSB-YP023924HU). Other recombinant proteases were purchased from R&D Systems, which included SARS-CoV-1 3CL/Mpro (E-718),

(6) Mechanism-Based Macrocyclic Inhibitors of Serine ProteasesJournal of Medicinal ChemistryMarch 28, 2024Vishnu C. Damalanka, Victoria Banas, Paolo De Bona, Maithri M. Kashipathy, Kevin Battaile, Scott Lovell, James W. Janetkawith recombinant HGFA (1514-SE-010, R&D Systems), matriptase (3946-SEB-010, R&D Systems), TMPRSS2 (CSB-YP023924HU, Cusabio Technology), or activated hepsin in black 384-well plates (Corning # 3575). [Hepsin activation:

(7) Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus ReplicationChemMedChemJanuary 15, 2024Colombo É, Désilets A, Hassanzadeh M, Lemieux G, Marois I, Cliche D, Delbrouck JA, Murza A, Jean F, Marsault E, et al.

(8) In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assaysBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieDecember 1, 2023van Eijk N, Schmacke LC, Steinmetzer T, Pilgram O, Poór M, Pászti-Gere E.

(9) Reactive Centre Loop Mutagenesis of SerpinB3 to Target TMPRSS2 and Furin: Inhibition of SARS-CoV-2 Cell Entry and ReplicationInternational Journal of Molecular SciencesOctober 19, 2022Saravjeet Singh, Sophie Oâ€™Reilly, Hossam Gewaid, Andrew G. Bowie, Virginie Gautier, D. Margaret WorrallInstitute, Slovenia. Recombinant human TMPRSS2 was obtained from Cusabio Technology, Houston, TX, USA) (CSB-YP023924HU) and recombinant human furin from BioLegend, CA, USA (719404). Proteases were incubated with a 1:5 molar

(10) Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 InfectionsmBioJune 28, 2022Rosendal E, Mihai IS, Becker M, Das D, Frängsmyr L, Persson BD, Rankin GD, Gröning R, Trygg J, Forsell M, et al.mesylate (3081) were purchased from R&D Systems. Active recombinant TMPRSS2 was purchased from Cusabio (CSB-YP023924HU). Tissue plasminogen activator (tPA, T0831) was purchased from Sigma. Expression plasmids encoding the

(11) Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19ACS Infectious DiseasesJune 10, 2022Jonathan H. Shrimp et al.TMPRSS2 protein expressed from yeast (human TMPRSS2 residues 106–492, N-terminal 6× His-tag) (cat. # CSB-YP023924HU) was acquired from Cusabio. The fluorogenic peptide substrate, Boc-QAR-AMC. HCl was obtained from Bachem

(12) Novel cleavage sites identified in SARS-CoV-2 spike protein reveal mechanism for cathepsin L-facilitated viral infection and treatment strategiesCell discoveryJune 6, 2022Zhao MM, Zhu Y, Zhang L, Zhong G, Tai L, Liu S, Yin G, Lu J, He Q, Li MJ, et al.

(13) A Suite of TMPRSS2 Assays for Screening Drug Repurposing Candidates as Potential Treatments of COVID-19bioRxivMarch 29, 2022Jonathan H. Shrimp et al.TMPRSS2 protein expressed from yeast (human TMPRSS2 residues 106–492, N-terminal 6x His-tag) (cat.# CSB-YP023924HU) was acquired from Cusabio. The fluorogenic peptide substrate, Boc-QAR-AMC. HCl was obtained from Bachem

(14) Potent Anti-SARS-CoV-2 Activity by the Natural Product Gallinamide A and Analogues via Inhibition of Cathepsin LJournal of medicinal chemistryFebruary 24, 2022Ashhurst AS, Tang AH, Fajtová P, Yoon MC, Aggarwal A, Bedding MJ, Stoye A, Beretta L, Pwee D, Drelich A, et al.(Sigma-Aldrich, C9521) was then added. Recombinant human TMPRSS2 was purchased from Cusabio Technology (CSB-YP023924HU) and assayed with 86 μM Boc-QAR-AMC in 25 mM Tris-HCl, 150 mM NaCl, 5 mM CaCl2, 0.01% Triton X-100,

(15) Antiviral Potential of the Antimicrobial Drug Atovaquone against SARS-CoV-2 and Emerging Variants of ConcernACS infectious diseasesNovember 12, 2021Carter-Timofte ME, Arulanandam R, Kurmasheva N, Fu K, Laroche G, Taha Z, van der Horst D, Cassin L, van der Sluis RM, Palermo E, et al.

(16) A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cellsProceedings of the National Academy of Sciences of the United States of AmericaOctober 26, 2021Mahoney M, Damalanka VC, Tartell MA, Chung DH, Lourenço AL, Pwee D, Mayer Bridwell AE, Hoffmann M, Voss J, Karmakar P, et al.S8E). Recombinant enzyme inhibition assays. Recombinant human TMPRSS2 was purchased from Cusabio Technology (CSB-YP023924HU) and assayed in 25 mM Tris·HCl, 150 mM NaCl, 5 mM CaCl2, 0.01% Triton X-100, pH 8.0 at a final concentration

(17) Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2Frontiers in Molecular BiosciencesApril 30, 2021Jacopo Sgrignani, Andrea CavalliBH was measured by MST. Recombinant human TMPRSS2 (106-492aa, 6xHisTag) was acquired from Cusabio (CSB-YP023924HU) and labeled using a His-tag-specific dye (Monolith His-Tag Labeling Kit RED-tris-NTA (MO-L018), NanoTemper® Technologies

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Recombinant Human Transmembrane protease serine 2(TMPRSS2),partial (Active) (Yeast)

Human TMPRSS2 Protein (Activity Verified) (Yeast) from CUSABIO Technology LLC

Sequence

CUSABIO Technology LLC

Citations (17)

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Human TMPRSS2 Protein (Activity Verified) (Yeast) from CUSABIO Technology LLC

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