Human CD137 / 4-1BB Protein (ECD, Fc Tag) 10041-H02H from Sino Biological, Inc.

Product Specs
ItemHuman CD137 / 4-1BB Protein (ECD, Fc Tag)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number10041-H02H
Size100 µg
Conjugate/TagC-human IgG1-Fc
FormatLyophilized from sterile PBS, pH 7.4
Purity≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human TNFRSF9 consists of 401 amino acids and predicts a molecular mass of 44 kDa. As a result of glycosylation, it migrates as an approximately 58.9 kDa band in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameTNFRSF9
Source/Expression SystemHEK293 Cells
NCBI Full Gene NameTNF receptor superfamily member 9
NCBI Gene Aliases4-1BB, CD137, CDw137, ILA, IMD109
Activity1.Immobilized Recombinant Human CD137 / 4-1BB Protein (ECD, Fc Tag) (Cat: 10041-H02H) at 0.1 µg/mL (100 µL/well) can bind Recombinant Human 4-1BBL/TNFSF9 Protein (AVI & Fc Tag), Biotinylated (Cat: 15693-H42H-B), the EC50 is 3-10 ng/mL (QC tested). 2.Loaded Biotinylated Recombinant Human 4-1BB Ligand/TNFSF9 Protein, Fc Tag (Cat. No. 15693-H42H-B) on SA Biosensor, can bind Recombinant Human 4-1BB/CD137 Protein, hFc Tag (Cat. No. 10041-H02H) with an affinity constant of 4.29 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 3.Immobilized Recombinant Human CD137 / 4-1BB Protein (ECD, Fc Tag) (Cat: 10041-H02H) at 1 µg/mL (100 µL/well) can bind Anti-4-1BB (Research Grade Utomilu*mab Biosimilar), the EC50 is 8.9 ng/mL (Routinely tested)

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 AgentsCancer immunology researchDecember 1, 2021Assi HH, Wong C, Tipton KA, Mei L, Wong K, Razo J, Chan C, Howng B, Sagert J, Krimm M, et al.#50124-M02H), B7–1 (Sino Biological, catalogs #10698-H02H and #50446-M02H), CD137 (Sino Biological, catalogs #10041-H02H and #50811-M02H), OX40 (Sino Biological, catalogs #10481-H02H and #50808-M02H), and GITR (R&D Systems,

(2) Novel anti-4-1BB×PD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockadeJournal for immunotherapy of cancerJuly 1, 2021Jeong S, Park E, Kim HD, Sung E, Kim H, Jeon J, Kim Y, Jung UJ, Son YG, Hong Y, et al.were purchased from Sino Biological (human PD-L1: 10084-H08H, monkey PD-L1: 90251-C08H, human 4-1BB: 10041-H02H, monkey 4-1BB: 90847-K02H, human B7-H3: 11188-H08H, human B7-H4: 10738-H08H, human OX40: 10481-H08H,

(3) CD137 ligand feedback upregulates PD-L1 expression on lung cancer via T cell production of IFN-γThoracic cancerDecember 1, 2019Wang H, Yan Z, Hao J, Yang B, Wang J, Yi L, Wang X, Li S, Zhang H, Zhang S.

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Human CD137 / 4-1BB Protein (ECD, Fc Tag)

Human CD137 / 4-1BB Protein (ECD, Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

Citations (3)

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Human CD137 / 4-1BB Protein (ECD, Fc Tag) from Sino Biological, Inc.

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