Human CD80 / B7-1 Protein (ECD, Fc Tag) 10698-H02H from Sino Biological, Inc.

Product Specs
ItemHuman CD80 / B7-1 Protein (ECD, Fc Tag)
CompanySino Biological, Inc.
Price $198.00Supplier Page View Company Product Page
Catalog Number10698-H02H
Conjugate/TagC-human IgG1-Fc
FormatLyophilized from sterile PBS, pH 7.4
Purity≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human CD80 consists of 446 amino acids and predicts a molecular mass of 50.6 kDa. As a result of glycosylation, it migrates as an approximately 65.8 kDa band in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameCD80
Source/Expression SystemHEK293 Cells
NCBI Full Gene NameCD80 molecule
NCBI Gene AliasesB7, B7-1, B7.1, BB1, CD28LG, CD28LG1, LAB7
Size100 µg
Activity1.Loaded Recombinant Human B7-1/CD80 Protein, hFc Tag (Cat. No. 10698-H02H) on ProA Biosensor, can bind Recombinant Human CTLA-4 Protein (Cat. No. 11159-HNAH) with an affinity constant of 2.09 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 2.Loaded Recombinant Human B7-1/CD80 Protein, hFc Tag (Cat. No. 10698-H02H) on proA Biosensor, can bind Recombinant Human, Cynomolgus, Rhesus CD28 Protein, His Tag (Cat. No. 90182-C08H) with an affinity constant of 0.895 µM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 3.Immobilized Recombinant Human CD80 / B7-1 Protein (ECD, Fc Tag) (Cat: 10698-H02H) at 5 µg/mL (100 µL/well) can bind Recombinant Human CTLA-4 Protein (ECD, Fc & AVI Tag), Biotinylated (Cat: 11159-H41H-B), the EC50 is 2.3 ng/mL (Routinely tested). 4.Immobilized Recombinant Human CD80 / B7-1 Protein (ECD, Fc Tag) (Cat: 10698-H02H) at 5 µg/mL (100 µL/well) can bind Recombinant Human PD-L1 Protein (Fc & AVI Tag), Biotinylated (Cat: 10084-H41H-B), the EC50 is 243 ng/mL (Routinely tested)

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) CTLA4 depletes T cell endogenous and trogocytosed B7 ligands via cis-endocytosisThe Journal of experimental medicineJuly 3, 2023Xu X, Dennett P, Zhang J, Sherrard A, Zhao Y, Masubuchi T, Bui JD, Chen X, Hui E.CD28−/−CTLA4ΔICD-mCherry+CD80+, or CD28−/−CTLA4ΔICD-mCherry+CD86+ Jurkat cells were incubated with 10 µg/ml soluble CD80-Ig (#10698-H02H-100; Sino Biological) or CD86-Ig (#775606; BioLegend) on ice for 30 min, washed twice with 1× PBS containing

(2) Soluble CTLA-4 mutants ameliorate immune-related adverse events but preserve efficacy of CTLA-4- and PD-1-targeted immunotherapyScience translational medicineMarch 1, 2023Liu M, Wang X, Du X, Wu W, Zhang Y, Zhang P, Ai C, Devenport M, Su J, Muthana MM, et al.

(3) Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 AgentsCancer immunology researchDecember 1, 2021Assi HH, Wong C, Tipton KA, Mei L, Wong K, Razo J, Chan C, Howng B, Sagert J, Krimm M, et al.#50503-M02H), PD-1 (Sino Biological, catalogs #10377-H02H and #50124-M02H), B7–1 (Sino Biological, catalogs #10698-H02H and #50446-M02H), CD137 (Sino Biological, catalogs #10041-H02H and #50811-M02H), OX40 (Sino Biological,

(4) A VEGFR2-MICA bispecific antibody activates tumor-infiltrating lymphocytes and exhibits potent anti-tumor efficacy in miceCancer immunology, immunotherapy : CIISeptember 1, 2019Xu Y, Zhang X, Wang Y, Pan M, Wang M, Zhang J.

(5) Immune Checkpoint Inhibitor-induced Reinvigoration of Tumor-infiltrating CD8⁺ T Cells is Determined by Their Differentiation Status in GlioblastomaClinical cancer research : an official journal of the American Association for Cancer ResearchApril 15, 2019Park J, Kwon M, Kim KH, Kim TS, Hong SH, Kim CG, Kang SG, Moon JH, Kim EH, Park SH, et al.

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Human CD80 / B7-1 Protein (ECD, Fc Tag)

Human CD80 / B7-1 Protein (ECD, Fc Tag) from Sino Biological, Inc.

Description

Sino Biological, Inc.

Citations (5)

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Human CD80 / B7-1 Protein (ECD, Fc Tag) from Sino Biological, Inc.

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