Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) (HPLC-verified) 10108-H08H from Sino Biological, Inc.

Product Specs
ItemHuman ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) (HPLC-verified)
CompanySino Biological, Inc.
Price $218.00Supplier Page View Company Product Page
Catalog Number10108-H08H
Size20 µg
Conjugate/TagC-His
FormatLyophilized from sterile PBS, pH 7.4
Purity> 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human ACE2 consists of 734 amino acids and predicts a molecular mass of 85.1 kDa
SpeciesHuman
Molecule NameACE2
Source/Expression SystemHEK293 Cells
Activity1. Measured by its binding ability in a functional ELISA. Immobilized 2019-nCoV Spike Protein (RBD, mFc Tag)(Cat: 40592-V05H) at 2 µg/mL (100 µL/well) can bind human ACE2 protein (His tag), the EC50 of ACE2 is 10-30 ng/mL. 2. Measured by its ability to cleave a fluorogenic peptide substrate, McaYVADAPK (Dnp)OH, R&D Systems, Catalog # ES007. The specific activity is >1000 pmols/min/µg. 3.Loaded Recombinant SARS-CoV-2 (2019-nCoV) Spike RBD-mFc Protein (Cat. No. 40592-V05H) on AMC Biosensor, can bind Recombinant Human ACE2 Protein, His Tag (Cat. No. 10108-H08H) with an affinity constant of 2.46 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 4.Recombinant SARS-CoV-2 (2019-nCoV) Spike S1 Protein, Fc Tag (Cat. No. 40591-V02H) captured on Protein A chip can bind Recombinant Human ACE2 Protein, His Tag (Cat. No. 10108-H08H) with an affinity constant of 1.50 nM as determined in an SPR assay (Biacore 8K) (Routinely tested)

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Neutralization of SARS-CoV-2 by IgM-14 via engagement of two distinct spike epitopesPLOS PathogensMarch 25, 2026Yan Wang, Yanping Hu, Zhiqiang Ku, Jason Yeung, Jing Zou, Michael Woodson, Nikolai S. Prokhorov, Ekaterina S. Knyazhanskaya, Haiqing Zhao, Michael B. Sherman, et al.were finally eluted in a buffer composed of 2 mM Tris, pH 8.0, 200 mM NaCl. The human ACE2 protein (10108-H08H) was purchased from Sino Biological. The Fc-tagged wild-type RBD protein and the RBD protein containing

(2) RESP2: An Uncertainty Aware Multi‐Target Multi‐Property Optimization AI Pipeline for Antibody DiscoveryAdvanced ScienceSeptember 4, 2025Jonathan Parkinson, Ryan Hard, Young Su Ko, Wei WangSARS COV‐2 RBD or 3.2 nM WT RBD (Acro Biosystems SPD‐C82E9) + 294 nM soluble ACE2 (Sino Biological 10108‐H08H) in 1% BSA‐PBS (100,000 cells per tube, 1:100 dilution 2276s anti‐c‐myc antibody). Afterwards, cells

(3) ACE2 Receptor and Antibody Binding to SARS-CoV-2 Spikes and Virions by Single-Molecule FluorescenceACS OmegaAugust 12, 2025Souradip Dasgupta, Srijan Ray, Aswin T. Srivatsav, Anthony L. DeVico, Krishanu Raysoluble Angiotensin-converting enzyme 2 (sACE2) protein was commercially procured from Sino Biological (#10108-H08H). sACE2, a homologue of sACE, regulates the renin angiotensin system (RAS) by counterbalancing the ACE

(4) Potential blocker of SARS-CoV entry and a narrow functionality of its spike protein motifs on Qubevirus platformJournal of Biological ChemistryJune 12, 2025Aristide Dzelamonyuy, Augustin Ntemafack, Millie M. Georgiadis, Alain Bopda Bopda Waffofrom ABClonal (Cat # A20135, AS014, and A21181). The rhACE2 was purchased from Sino Biological (Cat # 10108-H08H). The SARS-CoV pseudovirus neutralization kit was purchased from Virongy Biosciences. Methods Contact

(5) An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse modelsNat CommunMay 1, 2025Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, et al.and RBD-albumin fusions, plates were coated with 2 µg/mL of His-tagged recombinant human ACE2 (Cat. 10108-H08H, Sino Biological) before serial dilutions of RBD-MSA and RBD-HSA fusions (150 nM-0.023 nM) were added,

(6) Lysosomal “TRAP”: a neotype modality for clearance of viruses and variantsNature CommunicationsNovember 23, 2024Chengliang Lyu, Zhanlong He, Xiaoming Hu, Shuang Wang, Meng Qin, Li Zhu, Yanyan Li, Fengmei Yang, Zhouguang Jiao, Xiao Zhang, et al.protein utilized in the study was a commercial product and purchased from SinoBiological company (cat: 10108-H08H). This recombinant human ACE2 protein was produced by human HEK293T cells, in which the transferred

(7) Single-particle rotational sensing for analyzing the neutralization activity of antiviral antibodiesTalantaNovember 1, 2024Shang J, Li H, Liu X, Sun S, Huan S, Xiong B.

(8) Deciphering Pathways and Thermodynamics of Protein Assembly Using Native Mass SpectrometryJournal of the American Chemical SocietyOctober 23, 2024Bui DT, Kitova EN, Kitov PI, Han L, Mahal LK, Klassen JS.

(9) Expression and purification of SARS-CoV-2 receptor binding domain in Escherichia coli for diagnostic and therapeutic purposesResearch in Pharmaceutical SciencesOctober 22, 2024Hajarossadat Ghaderi, Alireza Shoari, Shima Salehi, Ayda Hassanzadeh Eskafi, Mahdi Habibi-Anbouhi, Reza Ahangari Cohan, Reza Moazzami, Mahdi Behdaniand expression of recombinant RBD, respectively. ACE2 was purchased from Sino Biological (Cat. No. 10108-H08H, Beijing, China). The pET-22b (+) vector (Novagen, USA) was used to clone the RBD protein gene downstream

(10) Biosensor-based active ingredient recognition system for screening potential small molecular Severe acute respiratory syndrome coronavirus 2 entry blockers targeting the spike protein from Rugosa roseBiomedical chromatography : BMCOctober 1, 2024Yu W, Yi SZ, Jiang CY, Guan JW, Xue R, Zhang XX, Zeng T, Tang H, Chen W, Han B.

(11) RESP2: An uncertainty aware multi-target multi-property optimization AI pipeline for antibody discoverybioRxiv : the preprint server for biologyJuly 31, 2024Parkinson J, Hard R, Ko YS, Wang W.SARS COV-2 RBD or 3.2 nM WT RBD (Acro Biosystems SPD-C82E9) + 294 nM soluble ACE2 (Sino Biological 10108-H08H) in 1% BSA-PBS (100,000 cells per tube, 1:100 dilution 2276s anti-c-myc antibody). Afterwards, cells

(12) Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mappingCommunications BiologyJuly 3, 2024Niklas Berndt Thalén, Maximilian Karlander, Magnus Lundqvist, Helena Persson, Camilla Hofström, S. Pauliina Turunen, Magdalena Godzwon, Anna-Luisa Volk, Magdalena Malm, Mats Ohlin, et al.Corning Costar (Kennebunk, ME, USA)). For competitive binding to S1 epitopes, recombinant human ACE2 (10108-H08H, SinoBiological (Beijing, China)), S1-binding antibody fragments scFvs, Fabs, human IgG1 CR3022 (srbd-mab1,

(13) Nasal delivery of encapsulated recombinant ACE2 as a prophylactic drug for SARS-CoV-2International journal of pharmaceuticsApril 25, 2024Baldelli A, Jerry Wong CY, Oguzlu H, Gholizadeh H, Guo Y, Ong HX, Singh A, Traini D, Pratap-Singh A.

(14) Rapid isolation of pan-neutralizing antibodies against Omicron variants from convalescent individuals infected with SARS-CoV-2Frontiers in immunologyJanuary 1, 2024Yu P, Ran J, Yang R, Zhu H, Lu S, Wu Y, Zhao T, Xiong T.expression medium (Kairuibiotech, K03252) under the same conditions. Recombinant proteins, including ACE2 (10108-H08H), Spike (BA.4/5) S1+S2 trimer (40589-V08H32), and Spike RBDs of BA.4/5 (40592-V08H130), XBB.1.5 (40592-V08H146),

(15) Surrogate Virus Neutralisation Test Based on Nanoluciferase-Tagged Antigens to Quantify Inhibitory Antibodies against SARS-CoV-2 and Characterise Omicron-Specific Reactivity in a Vaccination CohortVaccines (Basel)December 8, 2023Michael Schoefbaenker, Rieke Neddermeyer, Theresa Guenther, Marlin M. Mueller, Marie-Luise Romberg, Nica Classen, Marc T. Hennies, Eike R. Hrincius, Stephan Ludwig, Joachim E. Kuehn, et al.Germany) were coated with 200 ng/well of recombinant hACE2 (Sino Biological Inc., Beijing, China, #10108-H08H) diluted in 100 µL carbonate buffer at 4 °C for 16 h. The coated plates were washed four times using

(16) Superior immunogenicity of mRNA over adenoviral vectored COVID-19 vaccines reflects B cell dynamics independent of anti-vector immunity: Implications for future pandemic vaccinesVaccineNovember 22, 2023Liu Y, Sánchez-Ovando S, Carolan L, Dowson L, Khvorov A, Jessica Hadiprodjo A, Tseng YY, Delahunty C, Khatami A, Macnish M, et al.strain (YP_009724390.1) and Human angiotensin-converting enzyme 2 (hACE2) protein (Sino Biological, 10108-H08H). Sera were serially diluted 3-fold from 1:10 to 1:21870 for testing. GraphPad Prism version 9.5.1 for

(17) Mapping immunological and host receptor binding determinants of SARS-CoV spike protein utilizing the Qubevirus platformJournal of Biological ChemistryNovember 15, 2023Carrie Sanders, Aristide Dzelamonyuy, Augustin Ntemafack, Nadia Alatoom, Godwin Nchinda, Millie M. Georgiadis, Alain Bopda Waffofrom SARS-CoV patients was provided by NIH (61). The rhACE2 was purchased from Sino Biological (Cat# 10108-H08H). Construction of recombinant plasmid vectors for recombinant phages with various S protein fragments Fusion

(18) Effects of spike proteins on angiotensin converting enzyme 2 (ACE2)Archives of biochemistry and biophysicsOctober 15, 2023Bejoy J, Williams CI, Cole HJ, Manzoor S, Davoodi P, Battaile JI, Kaushik A, Nikolaienko SI, Brelidze TI, Gychka SG, et al.HIV-1 gp120 subtype A (Cat# 40403-V08H), HIV-1 gp120 subtype B (Cat# 40404-V08H), and human ACE2 (Cat# 10108-H08H) produced in HEK293 cells were purchased from Sino Biological Inc. (Wayne, PA, USA). Recombinant SARS-CoV

(19) A bioengineered pseudovirus nanoparticle displaying SARS‐CoV 2 RBD fully protects mice from mortality and weight loss caused by SARS‐CoV 2 challengeBiotechnology JournalOctober 1, 2023Ming Xia, Krisangel López, Frank S. Vago, Pengwei Huang, Dawn I. Auguste, Wen Jiang, Albert J. Auguste, Ming TanRBD to host receptors. To this end, the commercial recombinant ACE2 protein (Sino Biological, Cat: 10108-H08H) was used as the SARS-CoV-2 receptor. The ACE2 protein at 1 ng/μL was coated on microtiter plates overnight.

(20) Omicron BQ.1.1 and XBB.1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccinationCell ReportsJune 1, 2023Bin Ju, Qing Fan, Congcong Liu, Senlin Shen, Miao Wang, Huimin Guo, Bing Zhou, Xiangyang Ge, Zheng Zhang15575-038 SARS-CoV-2 WT RBD probe,Sino Biological Inc.,Cat# 40592-V08B Human ACE2,Sino Biological Inc.,Cat# 10108-H08H SARS-CoV-2 BA.2 spike trimer,Sino Biological Inc.,Cat# 40589-V08H28 SARS-CoV-2 WT RBD with His tag,Ju

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Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) (HPLC-verified)

Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) (HPLC-verified) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human ACE2 / Angiotensin-Converting Enzyme 2 Protein (His Tag) (HPLC-verified) from Sino Biological, Inc.

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