Human CTLA4 / CD152 Protein (Fc Tag) 11159-H02H6 from Sino Biological, Inc.

Product Specs
ItemHuman CTLA4 / CD152 Protein (Fc Tag)
CompanySino Biological, Inc.
Price $78.00Supplier Page View Company Product Page
Catalog Number11159-H02H6
Conjugate/TagC-human IgG1-Fc
FormatLyophilized from sterile PBS, pH 7.4
Purity≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe recombinant human CTLA4 consists of 368 amino acids and predicts a molecular mass of 40.7 kDa. As a result of glycosylation, the apparent molecular mass of human CTLA4 is approximately 46-55 kDa in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameCTLA4
Source/Expression SystemHEK293 Cells
NCBI Full Gene Namecytotoxic T-lymphocyte associated protein 4
NCBI Gene AliasesALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Activity1.Loaded Recombinant Human CTLA4 / CD152 Protein (Fc Tag) (Cat: 11159-H02H6) on ProA Biosensor, can bind Recombinant Human CD80 / B7-1 Protein (His Tag) (Cat: 10698-H08H) with an affinity constant of 210 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 2.Immobilized Recombinant Human CTLA4 / CD152 Protein (Fc Tag) (Cat: 11159-H02H6) at 2 µg/mL (100 µL/well) can bind Anti-CTLA4(Research grade Ipilimumab biosimilar), the EC50 is 2-6 ng/mL (Routinely tested). 3.Immobilized Recombinant Human CD86 / B7-2 Protein (His Tag) (Cat: 10699-H08H) at 2 µg/mL (100 µL/well) can bind Recombinant Human CTLA4 / CD152 Protein (Fc Tag) (Cat: 11159-H02H6), the EC50 is 3.5-10.5 ng/mL(Routinely tested). 4.Immobilized Recombinant Human CTLA4 / CD152 Protein (Fc Tag) (Cat: 11159-H02H6) at 10 µg/mL (100 µL/well) can bind Recombinant Human CD80 / B7-1 Protein (His Tag) (Cat: 10698-H08H), the EC50 is 0.2-0.8 µg/mL (QC tested)
Size50 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 AgentsCancer immunology researchDecember 1, 2021Assi HH, Wong C, Tipton KA, Mei L, Wong K, Razo J, Chan C, Howng B, Sagert J, Krimm M, et al.related Fc-tagged proteins (both human and mouse proteins) including CTLA-4 (Sino Biological, catalogs #11159-H02H6 and #50503-M02H), PD-1 (Sino Biological, catalogs #10377-H02H and #50124-M02H), B7–1 (Sino Biological,

(2) PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 PathwaysImmunityDecember 17, 2019Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, et al.11524-H02H Human CD28-muFc,ACROBiosystems,Cat # CD8-H52A5 Human CTLA-4-huFc,Sino Biological,Cat# 11159-H02H6 Human CTLA-4-muFc,ACROBiosystems,Cat # CT4-H52A4 Isolated huFc,Sino Biological,Cat# 10702-HNAH Isolated

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Human CTLA4 / CD152 Protein (Fc Tag)

Human CTLA4 / CD152 Protein (Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human CTLA4 / CD152 Protein (Fc Tag) from Sino Biological, Inc.

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