Description
Product Characteristics: Human DPH1 full-length ORF ( NP_001374, 1 a.a. - 363 a.a.) recombinant protein with GST-tag at N-terminal.
antibodies-online can provide customization with regards to expression system, tag location and sequence for our made to order proteins designed and produced in Germany. Please contact our customer support for further information.:
Target Information: Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2\, MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in synthesis of diphthamide in EEF2 (Liu et al., 2004 [PubMed 15485916]).[supplied by OMIM, Mar 2008]