Fig 1: Neurons have function MR1, but 5XFAD/MR1 KO mice have reduced NeuN staining. A, Representative immunostaining images of NeuN (black) in the cortex and hippocampus. B, Densitometry analysis using integrated pixel density of NeuN in (B) cortex and (C) CA1 hippocampus. D, IL‐2 production from MAIT cells that were co‐culture alone or with/without primary neurons, fixed E. coli, and/or anti‐MR1 antibody. Statistical analysis was performed using a two‐way ANOVA with Tukey multiple comparisons test (B–C) and one‐way ANOVA with Dunnett multiple comparisons test (D). *P < 0.05, ***P < 0.001, ***P < 0.001 (n = 3–6/group). The data are shown as the mean ± SEM. ANOVA, analysis of variance; KO, knock out; MAIT, mucosal‐associated invariant T; SEM, standard error of the mean.