CD19 Fc Chimera Protein 9269-CD-050 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemCD19 Fc Chimera Protein
CompanyR&D Systems, a Bio-Techne Brand
Price $528.00Supplier Page View Company Product Page
Catalog Number9269-CD-050
Size50 ug
ApplicationsBioactivity
Conjugate/TagUnconjugated
Purity>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining
SpeciesHuman
Molecule NameCD19
Source/Expression SystemCHO-derived Recombinant Human CD19 Fc Chimera Protein, CF
NCBI Full Gene NameCD19 molecule
NCBI Gene AliasesB4, CVID3
FormatLyophilized from a 0.2 µm filtered solution in PBS
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 3 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Sizes Available: 50 ug

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Simultaneous secretion of a PD-L1 x 4-1BB bispecific antibody improves antileukemic efficacy of STAb-T cells secreting a CD19-specific T-cell engagerOncoimmunologyDecember 31, 2025Marina Gómez-Rosel, Laura Rubio-Pérez, Ivana Zagorac, Carmen Domínguez-Alonso, Laura Díez-Alonso, Oana Hangiu, Rocío Navarro, Raúl Torres-Ruíz, Sandra Rodríguez-Perales, Francisco J. Blanco, et al.as negative controls. Enzyme-Linked Immunosorbent Assay (ELISA) Human CD19-Fc (5 μg/mL) (Cat. No. 9269-CD−050, R&D Systems), human PD-L1-Fc (2.5 μg/mL) (Cat. No. 156-B7−100, R&D Systems), or human 4-1BB-Fc (2.5

(2) Optimal pairing of binder and co-stimulatory domains improves dual CART cell efficacyMolecular therapy : the journal of the American Society of Gene TherapyNovember 5, 2025Shukla D, Manne S, Jiang S, Ruella M, Wherry EJ, Riley JL.4×108 beads/ml and then incubated overnight with 200μg of CD19 Fc Chimera Protein (R&D Systems; Cat#9269-CD-050) or CD22 protein (Sino Biological; Cat#11958-H08H1) at room temperature with gentle tilting and rotation.

(3) Simultaneous secretion of a PD-L1 x 4-1BB bispecific antibody improves antileukemic efficacy of STAb-T cells secreting a CD19-specific T-cell engagerOncoimmunologyOctober 26, 2025Marina Gómez-Rosel, Laura Rubio-Pérez, Ivana Zagorac, Carmen Domínguez-Alonso, Laura Díez-Alonso, Oana Hangiu, Rocío Navarro, Raúl Torres-Ruíz, Sandra Rodríguez-Perales, Francisco J. Blanco, et al.as negative controls. Enzyme-Linked Immunosorbent Assay (ELISA) Human CD19-Fc (5 μg/mL) (Cat. No. 9269-CD−050, R&D Systems), human PD-L1-Fc (2.5 μg/mL) (Cat. No. 156-B7−100, R&D Systems), or human 4-1BB-Fc (2.5

(4) Tandem CD19/CD22 CAR T-cells as potential therapy for children and young adults with high-risk r/r B-ALLEBioMedicineAugust 1, 2025González-Martínez B, Galán-Gómez V, Navarro-Zapata A, Mirones-Aguilar I, Cobo M, Pernas-Sánchez A, Vallejo S, Sánchez-Zapardiel E, León-Triana O, Echecopar C, et al.anti-CD4-VioBlue was from Miltenyi Biotec (Cat. No. 130-113-219); anti-CD19-Fc was from R&D system (9269-CD-050); Alexa Fluor® 647 AffiniPure® F(ab')2 Fragment Goat Anti-Human IgG was from Jackson ImmunoResearch

(5) IFN-γ–resistant CD28 CAR T cells demonstrate increased survival, efficacy, and durability in multiple murine tumor modelsScience Translational MedicineJune 4, 2025Stefanie R. Bailey, Hana N. Takei, Giulia Escobar, Michael C. Kann, Amanda A. Bouffard, Tamina Kienka, Valentina M. Supper, Alexander Armstrong, Diego Salas-Benito, Merle K. Phillips, et al.or 18 hours with plate-bound CD19 (Recombinant Human CD19 Fc Chimera Protein, CF; R&D Systems Cat. 9269-CD-050), mesothelin (Recombinant Human Mesothelin; PeproTech Cat. 100–63), or EGFR (Recombinant Human EGF Receptor (EGFR

(6) Tandem CAR T-cells targeting CD19 and NKG2DL can overcome CD19 antigen escape in B-ALLFront ImmunolMay 9, 2025Jennifer Bolsée, Benjamin Violle, Céline Jacques-Hespel, Thuy Nguyen, Caroline Lonez, Eytan BremanCD19-binding domain was detected using a recombinant human CD19 tagged with a human Fc (rhCD19-Fc, 9269-CD-050, R&D systems) that was recognized by an anti-human IgG-Fc antibody (12-4998-82, ThermoFisher). NKG2DL-binding

(7) Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responsesJCI insightSeptember 8, 2022Bolivar-Wagers S, Loschi ML, Jin S, Thangavelu G, Larson JH, McDonald-Hyman CS, Aguilar EG, Saha A, Koehn BH, Hefazi M, et al.

(8) Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell EngagersCancer Immunology ResearchApril 1, 2022Belén Blanco et al.detect the 19-BiTE secreted to culture supernatants, human CD19:human Fc chimera (CD19:Fc; catalog no. 9269-CD-050, R&D Systems) was immobilized (5 μg/mL) on Maxisorp plates (catalog no. M9410-1CS, NUNC) overnight at

(9) A rational approach to assess off-target reactivity of a dual-signal integrator for T cell therapyToxicology and applied pharmacologyFebruary 15, 2022Wang X, Wong LM, McElvain ME, Martire S, Lee WH, Li CZ, Fisher FA, Maheshwari RL, Wu ML, Imun MC, et al.

(10) Overcoming CAR-Mediated CD19 Downmodulation and Leukemia Relapse with T Lymphocytes Secreting Anti-CD19 T-cell EngagersCancer Immunol ResFebruary 14, 2022Belén Blanco, Ángel Ramírez-Fernández, Clara Bueno, Lidia Argemí-Muntadas, Patricia Fuentes, Óscar Aguilar-Sopeña, Francisco Gutierrez-Agüera, Samanta Romina Zanetti, Antonio Tapia-Galisteo, Laura Díez-Alonso, et al.detect the 19-BiTE secreted to culture supernatants, human CD19:human Fc chimera (CD19:Fc; catalog no. 9269-CD-050, R&D Systems) was immobilized (5 μg/mL) on Maxisorp plates (catalog no. M9410-1CS, NUNC) overnight at

(11) HLA-independent T cell receptors for targeting tumors with low antigen densityNature medicineFebruary 1, 2022Mansilla-Soto J, Eyquem J, Haubner S, Hamieh M, Feucht J, Paillon N, Zucchetti AE, Li Z, Sjöstrand M, Lindenbergh PL, et al.in 100ul MACS buffer containing increasing concentrations of recombinant hCD19-hFc (R&D Systems, CF 9269-CD-050), at 4 °C for 60min. After a wash with 2ml of MACS buffer, cells were resuspended in 100ul MACS buffer

(12) Liposome-based nanocarriers loaded with anthrax lethal factor and armed with anti-CD19 VHH for effectively inhibiting MAPK pathway in B cellsInternational immunopharmacologyNovember 1, 2021Banihashemi SR, Rahbarizadeh F, Zavaran Hosseini A, Ahmadvand D, Khoshtinat Nikkhoi S.

(13) HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responsesCell host & microbeMarch 10, 2021Clayton KL, Mylvaganam G, Villasmil-Ocando A, Stuart H, Maus MV, Rashidian M, Ploegh HL, Walker BD.Cat#28990944) the Lingwood Lab (Ragon Institute of MGH, MIT and Harvard). Recombinant CD19-Fc (R&D Systems, Cat#9269-CD-050) and the purified soluble envelope protein were coated overnight on a Not Treated, sterile 96 well plate

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CD19 Fc Chimera Protein

CD19 Fc Chimera Protein

CD19 Fc Chimera Protein

CD19 Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

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CD19 Fc Chimera Protein from R&D Systems, a Bio-Techne Brand

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