Human IGFBP3 / IBP3 Protein (His Tag) 10430-H07H from Sino Biological, Inc.

Product Specs
ItemHuman IGFBP3 / IBP3 Protein (His Tag)
CompanySino Biological, Inc.
Price $348.00Supplier Page View Company Product Page
Catalog Number10430-H07H
Conjugate/TagN-His
Purity> 85 % as determined by SDS-PAGE
TypeRecombinant protein
Molecular WeightThe secreted recombinant human IGFBP3 comprises 280 amino acids with a predicted molecular mass of 31 kDa. As a result of glycosylation, the apparent molecular mass of rhIGFBP3 is approximately 40-45 kDa in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameIGFBP3
Source/Expression SystemHEK293 Cells
NCBI Full Gene Nameinsulin like growth factor binding protein 3
NCBI Gene AliasesBP-53, IBP3
Activity1. Measured by its binding ability in a functional ELISA. Immobilized human IGF2 (Cat:13032-H24E) at 10 µg/mL (100 µl/well) can bind biotinylated Human His-IGFBP3, The EC50 of biotinylated Human His-IGFBP3 is 18 ng/mL. 2. Measured by its binding ability in a functional ELISA. Immobilized human IGF1 (Cat:10598-H24E) at 10 µg/mL (100 µl/well) can bind biotinylated Human His-IGFBP3, The EC50 of biotinylated Human His-IGFBP3 is 24 ng/mL. 3. Measured by its ability to inhibit the biological activity of IGFI or IGFII on MCF7 human breast adenocarcinoma cells (Karey, K.P. et al. (1988) Cancer Research 48:4083.). The ED50 for this effect is typically 0.05-0.2 µg/mL in the presence of 14 ng/mL human IGFII
FormatLyophilized from sterile PBS, pH 7.4
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Immunoaffinity Mass Spectrometry Diagnostic Tests for Multi-Biomarker AssaysMethods in molecular biology (Clifton, N.J.)January 1, 2023Bringans S, Casey T, Ito J, Lumbantobing T, O'Neill R, Lipscombe R.

(2) Opposing Roles of IGFBP-3 and Heparanase in Regulating A549 Lung Cancer Cell SurvivalCellsNovember 8, 2022Al Khashali H, Wareham J, Ray R, Haddad B, Coleman KL, Ranzenberger R, McCombs P, Guthrie J, Heyl D, Evans HG.biotin-hyaluronan (B1557) were purchased from Sigma-Aldrich (Burlington, MA, USA). The IGFBP-3 protein (10430-H07H) was purchased from SinoBiological (Wayne, PA, USA). The heparanase inhibitor OGT 2115 was obtained

(3) IGFBP-3 functions as a molecular switch that mediates mitochondrial and metabolic homeostasisFASEB journal : official publication of the Federation of American Societies for Experimental BiologyJanuary 1, 2022Stuard WL, Titone R, Robertson DM.

(4) Validation of a multiplexed LC-MS/MS clinical assay to quantify insulin-like growth factor-binding proteins in human serum and its application in a clinical studyToxicology and applied pharmacologyMay 15, 2019Liu N, Tengstrand E, Boernsen KO, Bek S, Hsieh F.

(5) Mutual regulation between IGF-1R and IGFBP-3 in human corneal epithelial cellsJournal of cellular physiologyFebruary 1, 2019Titone R, Zhu M, Robertson DM.

(6) Novel nuclear localization and potential function of insulin-like growth factor-1 receptor/insulin receptor hybrid in corneal epithelial cellsPloS oneJanuary 1, 2012Wu YC, Zhu M, Robertson DM.

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Human IGFBP3 / IBP3 Protein (His Tag)

Human IGFBP3 / IBP3 Protein (His Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human IGFBP3 / IBP3 Protein (His Tag) from Sino Biological, Inc.

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