Human B7-H3 / CD276 Protein (ECD,His Tag) 11188-H08H from Sino Biological, Inc.

Product Specs
ItemHuman B7-H3 / CD276 Protein (ECD,His Tag)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number11188-H08H
Conjugate/TagC-His
Purity≥ 98 % as determined by SDS-PAGE ≥ 90 % as determined by SEC-HPLC. ≥ 90 % as determined by SEC-MALS(Routinely tested)
TypeRecombinant protein
Molecular WeightThe recombinant human CD276 consists of 444 amino acids and predictes a molecular mass of 48 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of human CD276 is approximately 68 kDa due to glycosylation. The molecular weight of this protein is around 61 kDa verified by SEC-MALS (Routinely tested)
SpeciesHuman
Molecule NameCD276
Source/Expression SystemHEK293 Cells
FormatLyophilized from sterile PBS, pH 7.4
NCBI Full Gene NameCD276 molecule
NCBI Gene Aliases4Ig-B7-H3, B7-H3, B7H3, B7RP-2
Activity1.Immobilized Anti-Human B7H3 antibody, human IgG1 at 2 µg/mL (100 µL/well) can bind Recombinant Human B7-H3 / CD276 Protein (ECD,His Tag) (Cat:11188-H08H), The EC50 is 2.5-7.5 ng/mL. 2.Loaded Enoblituzumab on proA Biosensor, can bind Recombinant Human B7-H3 Protein, His Tag (Cat. No. 11188-H08H) with an affinity constant of 1.06 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested)
Size100 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) A Moderate-Affinity Antibody–Drug Conjugate Targeting B7-H3 Exerts Potent Antitumor EfficacyPharmaceuticals (Basel)April 8, 2026Ziyu Zhang, Huifang Zong, Zhen Li, Shusheng Wang, Xiaodong Xiao, Yueqing Xie, Jianwei ZhuBio-Layer Interferometry Assay Recombinant human B7-H3 (rhB7-H3) protein (4Ig B7-H3, His tag) (Cat: 11188-H08H, Sino Biological, Inc., Beijing, China), composed of the full-length extracellular domain of human B7-H3

(2) B7-H3-mediated cis-inhibition of EGFR by a tumor-selective bispecific antibody enhances anti-tumor efficacy and minimizes toxicitiesNature CommunicationsFebruary 24, 2026Jian Guan, Tiongsun Chia, Bin Li, Tianyu Zhu, Zhengguang Liao, Junjie Deng, Fenggen Fu, Weiwei Wu, Chengtao Liu, Ya Liu, et al.for 100 seconds. The analytes, 2Ig-B7-H3 (Sino Biological, 29849-H08H), 4Ig-B7-H3 (Sino Biological, 11188-H08H), and EGFR (Acro Biosystems, EGR-H5222) were prepared at 100 nM, associated with the antibody for 100

(3) Design and Preclinical Validation of an Anti-B7-H3-Specific Radiotracer: A Non-Invasive Imaging Tool to Guide B7-H3-Targeted TherapiesPharmaceuticals (Basel)September 30, 2025Cyprine Neba Funeh, Fien Meeus, Niels Van Winnendael, Timo W. M. De Groof, Matthias D’Huyvetter, Nick DevoogdtThermoFisher, Waltham, MA, USA) were coated with 1 µg/mL of the 3 B7-H3 recombinant proteins: h4IgB7-H3 (cat. 11188-H08H, Sino Biologicals, Beijing, China), h2IgB7-H3 (cat. 50973-M08H, Sino Biologicals, Beijing, China), and

(4) Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunityNature communicationsApril 14, 2025Huang Y, Zhong WQ, Yang XY, Shan JL, Zhou L, Li ZL, Guo YQ, Zhang KM, Du T, Zhang HL, et al.was immunized by human 4Ig-B7H3-His fusion protein with an extracellular domain (Met1-Thr461) (Cat. 11188-H08H, Sino Biological) for five times, then its spleen was isolated to obtain B cells. Monoclonal B7H3 antibodies

(5) A Novel Anti-B7-H3 × Anti-CD3 Bispecific Antibody with Potent Antitumor ActivityLife (Basel, Switzerland)January 21, 2022Feng Y, Xie K, Yin Y, Li B, Pi C, Xu X, Huang T, Zhang J, Wang B, Gu H, et al.immunized with recombinant extracellular domain of human B7-H3 linked to His tag protein (B7-H3-ECD) (11188-H08H, SinoBiological, Beijing, China). Parental mAb against B7-H3 were screened based on the results of the

(6) Novel anti-4-1BB×PD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockadeJournal for immunotherapy of cancerJuly 1, 2021Jeong S, Park E, Kim HD, Sung E, Kim H, Jeon J, Kim Y, Jung UJ, Son YG, Hong Y, et al.10084-H08H, monkey PD-L1: 90251-C08H, human 4-1BB: 10041-H02H, monkey 4-1BB: 90847-K02H, human B7-H3: 11188-H08H, human B7-H4: 10738-H08H, human OX40: 10481-H08H, human GITR: 10643-H08H). Each well of the Nunc Maxisorp

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Human B7-H3 / CD276 Protein (ECD,His Tag)

Human B7-H3 / CD276 Protein (ECD,His Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human B7-H3 / CD276 Protein (ECD,His Tag) from Sino Biological, Inc.

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