Mouse IL4 / Interleukin-4 Protein 51084-MNAE from Sino Biological, Inc.

Product Specs
ItemMouse IL4 / Interleukin-4 Protein
CompanySino Biological, Inc.
Price $58.00Supplier Page View Company Product Page
Catalog Number51084-MNAE
Conjugate/TagUnconjugated
Purity> 90 % as determined by SDS-PAGE
TypeRecombinant protein
Molecular Weighthe recombinant mouse IL4 consists of 119 amino acids and predicts a molecular mass of 13.4 KDa. It migrates as an approximately 14 KDa band in SDS-PAGE under reducing conditions
SpeciesMouse
Molecule NameIL4
Source/Expression SystemE. coli
Activity1.Measured in a cell proliferation assay using HT-2 mouse T cells. The ED50 for this effect is typically 0.4-4 ng/mL. 2.Immobilized Recombinant Mouse IL4 / Interleukin-4 Protein (Cat: 51084-MNAE) at 5 µg/mL (100 µL/well) can bind Recombinant Mouse IL4R Protein (Fc Tag) (Cat: 51180-M02H), the EC50 is 1.0-3.0 ng/mL (QC tested)
FormatLyophilized from sterile PBS, pH 7.4
Size5 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) A distinct TCR+CD19+ population in the peritoneal cavity: B1a cells as precursors of extrathymic T cellsiScienceApril 17, 2026Su-Min Yee, Jeong-Eun Seon, Jae-Eun Seo, Hae-Jin Seo, Ja-Hun Seo, Seo-Hee Moon, Hyun-Su Koo, Ha-Rim Choi, Su-Man Kim, Hyung-Sik KangRecombinant Mouse IL-2 Protein,Sino Biological Inc.,Cat#51061-MNAE Recombinant Mouse IL-4 Protein,Sino Biological Inc.,Cat#51084-MNAE Recombinant Mouse IL-7 Protein,Sino Biological Inc.,Cat#50217-MNAE Recombinant Mouse IL-21 Protein,Sino Biological Inc

(2) The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell CarcinomaAdvanced ScienceJanuary 29, 2026Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, et al.treated for 24 h: an untreated control, a positive control stimulated with 25 ng/mL IL‐4 (SinoBiological, 51084‐MNAE), and an experimental group treated with 25 ng/mL LAMA4 (Origene, TP724250). Cells were then harvested,

(3) Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal CancerAdvanced ScienceJanuary 1, 2026Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, et al.Sino Biological, Beijing, 51048‐MNAE) and 10 ng mL−1 interleukin‐4 (IL‐4, Sino Biological, Beijing, 51084‐MNAE). Cells were seeded at a density of 1 × 10⁶ cells mL−1 in six‐well plates and incubated at 37 °C with

(4) Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microgliaDrug deliveryDecember 1, 2025Rafiei M, Shojaei A, Chau Y.Sigma–Aldrich (MO, USA). Recombinant Mouse IL-10 Protein (50245-MNAE), Recombinant Mouse IL-4 Protein (51084-MNAE), and Recombinant Mouse IL-13 Protein (50225-MNAH) were purchased from Sino Biological (Beijing, China).

(5) Vitiligo Signature‐Based Drug Screening Identifies Fulvestrant as a Novel Immunotherapy Combination StrategyAdvanced ScienceNovember 1, 2025Jie Zhu, Liting Huang, Suzhen Bi, WeiKaixin Kong, Wanting Feng, Yingjia Li, Zhengwei Xie, Peipei Shan, Sujie Zhupolarization medium containing 25 ng mL−1 M‐CSF1, 20 ng mL−1 interleukin‐4 (IL‐4; Sino Biological, 51084‐MNAE), and 20 ng mL−1 interleukin‐13 (IL‐13; Novoprotein, CX56). Fulvestrant was then added to the culture.

(6) Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10-Notch signalingSignal Transduct Target TherOctober 8, 2025Ke Wang, Jingwen Liao, Yue Yuan, Zhifu Chen, Qiang Gou, Haiming Jing, Mengmeng Liang, Yuanda Tang, Pengju Yan, Xiaoqian Yu, et al.University. Reagents Recombinant mouse GM-CSF (Sino Biological, Cat# 51048-MNAH), recombinant mouse IL-4 (Sino Biological, Cat# 51084-MNAE), and recombinant human Flt3L (Sino Biological, Cat# 10315-HNAE) were utilized for the cultivation of

(7) From inflammation to healing: the crucial role of GPR91 activation and SDH inhibition in chronic diabetic wound recoveryStem cell research & therapyJuly 23, 2025Liu H, Zhao S, Wang H, He X, Gao S, Su M, Zhen M, Chen S, Chen L, Xie J.NG and HG RAW 264.7 and BMDMs cells were polarized into M2 macrophages by treating them with IL-4 (51084-MNAE; Sino Biological) and IL-13 (50225-MNAH; Sino Biological) at a concentration of 20 ng/mL for 24 h. The

(8) Tailoring an intravenously injectable oncolytic virus for augmenting radiotherapyCell reports. MedicineMay 20, 2025Xu C, Chen L, Liu G, Xu J, Lv W, Gao X, Xu P, Tang M, Wang Y, Zhao X, et al.(China),B861682 Murine GM-CSF,Sino Biological Inc (China),51048-M01H Murine IL-4,Sino Biological Inc (China),51084-MNAE Potassium iodide,Aladdin (China),P116284 Cy5.5-NHS ester,Aladdin (China),1469277-96-0 OVA257-264(SIINFEKL),Top

(9) TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositisNat CommunMay 15, 2025Yimei Lai, Shuang Wang, Tingting Ren, Jia Shi, Yichao Qian, Shuyi Wang, Mianjing Zhou, Ryu Watanabe, Mengyuan Li, Xinyuan Ruan, et al.anti-IFNγ antibody (Clone# R4-6A2, 5 μg/ml, BioLegend, Cat# 505702), IL-4 (20 ng/ml, Sino Biological, Cat# 51084-MNAE), and IL-2 (20 ng/ml). Th17 cells: anti-IFNγ antibody (5 μg/ml), anti-IL-4 antibody (5 μg/ml), TGFβ1

(10) RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancerJ Transl MedFebruary 17, 2025Songliu Hu, Ning Zhan, Jian Li, Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, et al.factor (GenScript, Nanjing, China, Z03300) and interleukin (IL)-4 (SinoBiological, Beijing, China, 51084-MNAE). The bottom chamber contained 600 µL conditioned medium (without FBS) containing H520 cells or the

(11) STING-activating dendritic cell-targeted nanovaccines that evoke potent antigen cross-presentation for cancer immunotherapyBioactive materialsDecember 1, 2024Nguyen NT, Le XT, Lee WT, Lim YT, Oh KT, Lee ES, Choi HG, Youn YS.purchased from PeproTech (Thermo Fisher Scientific, MA, USA). Recombinant mouse IL-4 protein (cat. no. 51084-MNAE) was purchased from Sino Biological (Beijing, China). Human FLT3-ligand (research grade) was purchased

(12) Prior Fc receptor activation primes macrophages for increased sensitivity to IgG via long-term and short-term mechanismsDevelopmental cellNovember 4, 2024Bond A, Fiaz S, Rollins K, Nario JEQ, Snyder ET, Atkins DJ, Rosen SJ, Granados A, Dey SS, Wilson MZ, et al.were added to the cells for 24 hours. For M2 polarized cells, 20 ng/ml IL-4 (Sino Biological, Cat# 51084-MNAE) was added to the cells for 24 hours. The BMDMs were then collected for RNA extraction. Optogenetic

(13) CD5L up-regulates the TGF-β signaling pathway and promotes renal fibrosisLife sciencesOctober 1, 2024Chen C, Feng C, Luo Q, Zeng Y, Yuan W, Cui Y, Tang Z, Zhang H, Li T, Peng J, et al.

(14) Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosinBMC pharmacology & toxicologyApril 22, 2024Tian C, Liu Q, Zhang X, Li Z.

(15) Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinomaNature communicationsFebruary 2, 2024Liu C, Zhou C, Xia W, Zhou Y, Qiu Y, Weng J, Zhou Q, Chen W, Wang YN, Lee HH, et al.obtained from PeproTech. Human IFN-γ (cat. no. 570202) was obtained from BioLegend. Mouse IL-4 (cat. no. 51084-MNAE) and mouse IFN-γ (cat. no. 50709-MNAH) were obtained from Sino Biological. The ALKi crizotinib (cat.

(16) MCT1-governed pyruvate metabolism is essential for antibody class-switch recombination through H3K27 acetylationNature communicationsJanuary 2, 2024Chi W, Kang N, Sheng L, Liu S, Tao L, Cao X, Liu Y, Zhu C, Zhang Y, Wu B, et al.purchased from Sigma. SRBC was purchased from Solarbio (S9702). IL-4 was purchased from Sino Biological (51084-MNAE). AZD3965 was purchased from Cayman (No. 19912). BMS-303141 (ACL inhibitor) was purchased from MCE (HY-16107). Mice

(17) Medrysone promotes corneal injury repair by promoting M2-like polarization of macrophagesBMC ophthalmologyDecember 11, 2023Zhu Y, Jin X, Fu N, Li J.

(18) mRNA Delivery Platform Based on Bacterial Outer Membrane Vesicles for Tumor VaccineBio-protocolJuly 5, 2023Gao X, Li Y, Nie G, Zhao X.83264)β-Mercaptoethanol (β-ME) (Gibco, catalog number: 21985023)IL-4 (Sino Biological, catalog number: 51084-MNAE)Granulocyte-macrophage colony-stimulating factor (GM-CSF) (Sino Biological, catalog number: 51048-M01H)FITC-anti-mouse CD11c

(19) Tolperisone induces UPR-mediated tumor inhibition and synergizes with proteasome inhibitor and immunotherapy by targeting LSD1Expert opinion on therapeutic targetsJuly 1, 2023Jiang W, Yang Z, Chen P, Zhao M, Wang Y, Wang J, Li X, Wang M, Hou P.

(20) Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophageImmunity, inflammation and diseaseFebruary 1, 2023Bao X, Liu B, Jiang Y, Feng T, Cao W, Shi J, Jiang Y, Chen X, Yang J, Li J, et al.macrophages was divide equally in a six‐well plate and co‐stimulated with 20 ng/mL IL‐4 (Sino Biological, 51084‐MNAE) and 10 ng/mL IL‐13 (Sino Biological, 50225‐MNAH) for 48 h to induce M2. 2.4 Allergic rhinitis modeling The

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Mouse IL4 / Interleukin-4 Protein

Mouse IL4 / Interleukin-4 Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Mouse IL4 / Interleukin-4 Protein from Sino Biological, Inc.

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