Human CD16a / FCGR3A Protein (176 Phe, His Tag) 10389-H08H from Sino Biological, Inc.

Product Specs
ItemHuman CD16a / FCGR3A Protein (176 Phe, His Tag)
CompanySino Biological, Inc.
Price $2,148.00Supplier Page View Company Product Page
Catalog Number10389-H08H
Conjugate/TagC-His
Purity≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ≥ 90 % as determined by SEC-MALS(Routinely tested)
TypeRecombinant protein
Molecular WeightThe secreted recombinant human CD16a consists of 203 amino acids and has a predicted molecular mass of 23.3 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of human CD16a is approximately 45.2 kDa due to glycosylation. The molecular weight of this protein is around 36-48 kDa verified by SEC-MALS (Routinely tested)
SpeciesHuman
Molecule NameFCGR3A
Source/Expression SystemHEK293 Cells
FormatLyophilized from sterile PBS, pH 7.4
Activity1. Loaded Recombinant Human CD16a / FCGR3A Protein (F176, His Tag) (Cat: 10389-H08H) on His1K Biosensor, can bind anti-VEGFA(Research grade Bevacizumab Biosimilar) with an affinity constant of 1.9 µM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 2. anti-VEGFA(Research grade Bevacizumab Biosimilar) captured on ProA chip, can bind Recombinant Human CD16a / FCGR3A Protein (F176, His Tag) (Cat: 10389-H08H) with an affinity constant of 2.67 µM as determined in an SPR assay (Biacore T200) (Routinely tested). 3. Recombinant Human CD16a / FCGR3A Protein (F176, His Tag) (Cat: 10389-H08H) captured on CM5 Chip via Anti-his antibody chip, can bind anti-CD20(Research grade Rituximab Biosimilar) with an affinity constant of 0.499 µM as determined in an SPR assay (Biacore T200) (QC tested)
Size1 mg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) A MERTK-Targeting Antibody-Drug Conjugate Selectively Depletes M2 Tumor-Associated Macrophages and MERTK-Expressing Cancer CellsCancer ResApril 15, 2026Shugaku Takeda, Subhasree Sridhar, Daniel Schefer, Celia Andreu-Agullo, Pui C. Lo, Minhee Lee, Robert Busby, David M. Darst, Anne Assmus, Suresh Anaganti, et al.Uppsala, Sweden). The following Fc gamma receptors were obtained by Sino Biological: FcgRIllA176Phe (10389-H08H), FcgRIllA176val (10389-H08H1), FcgRIlIB (11046-H08H), FcgRIIA167Arg (10374-H08H), FcgRIlA167His (10374-H08H1),

(2) Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMVCell ReportsDecember 23, 2025Ahlam N. Qerqez, Katja Hoffmann, Alison G. Lee, Sumit Pareek, Kelli Hager, Akaash K. Mishra, George Delidakis, Kirsten Bentley, Lauren Kerr-Jones, Mica Cabrera, et al.FCM-H82W4 Calcein AM,BD Pharmingen,Cat# 564061 "CD16A F158 ectodomain, His tag",SinoBiological,Cat# 10389-H08H "CD16A V158 ectodomain, His tag",SinoBiological,Cat# 10389-H27H Flash Red 1μm Beads,Bangs Laboratories,Cat#

(3) Systematic analysis of Fc mutations designed to reduce binding to Fc-gamma receptorsmAbsDecember 31, 2024Geoff Hale, Jelle De Vos, Alastair Douglas Davy, Koen Sandra, Ian Wilkinson,Sino Biological,10374-H08H1 FcγRIIb (CD32b),human,Sino Biological,10259-H08H FcγRIIIa (CD16a) 158F allele,human,Sino Biological,10389-H08H FcγRIIIa (CD16a) 158 V allele,human,Sino Biological,10389-H08H1 FcγRIIIb (CD16b) NA1 allele,human,Sino Biological

(4) Enhanced efficacy of glycoengineered rice cell-produced trastuzumabPlant biotechnology journalNovember 1, 2024Shin JH, Oh S, Jang MH, Lee SY, Min C, Eu YJ, Begum H, Kim JC, Lee GR, Oh HB, et al.(SPR) The binding of TMab and P‐TMab to human FcγRIIIa variants (V158 and F158 allotypes) (10389‐H08H1 and 10389‐H08H; Sino Biological, Beijing, China) was assessed using a Biacore X100 surface plasmon resonance biosensor

(5) FcyRIIB is a novel immune checkpoint in the tumor microenvironment limiting activity of Treg-targeting antibodiesbioRxivJuly 4, 2023David Knorr, Rom Leidner, Shawn Jensen, Ryan Meng, Andrew Jones, Carmen Ballesteros-Merino, R. Bryan Bell, Maria Baez, David Sprott, Carlo Bifulco, et al.(Sino Biological, 11159-HNAH), and human FcyRs (human FCGR2A #10374-H08H, human FCGR2B #10259-H08H, human FCGR3A #10389-H08H, Sino Biological). 96 well ELISA Half Area High Binding plates (Greiner Bio-One, #675061) were coated

(6) Anti-SARS-CoV-2 antibodies elicited by COVID-19 mRNA vaccine exhibit a unique glycosylation patternCell ReportsDecember 14, 2021Inbal Farkash, Tali Feferman, Noy Cohen-Saban, Yahel Avraham, David Morgenstern, Grace Mayuni, Natasha Barth, Yaniv Lustig, Liron Miller, Dror S. Shouval, et al.FcγRIIB,Sino Biological,Cat# 10259-H08H the human recombinant receptors FcγR,Sino Biological,Cat# 10389-H08H C1q,Sigma Aldrich,Cat# C1740 Nonident P40 Substitute (GEPAL),Sigma Aldrich,Cat# CA-630 TopTip Borate

(7) FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodiesProceedings of the National Academy of Sciences of the United States of AmericaJune 9, 2020Borghi S, Bournazos S, Thulin NK, Li C, Gajewski A, Sherwood RW, Zhang S, Harris E, Jagannathan P, Wang LX, et al.FcγRIIb (10259H08H, Sino Biological), FcγRIIIaV158 (10389-H08H1, Sino Biological), and FcγRIIIaF158 (10389-H08H, Sino Biological). The FcγRs were injected through flow cells at a flow rate of 20 μL·min−1 with the

(8) Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: a requirement for stable antibody interactionsJournal of proteome researchDecember 5, 2014Hayes JM, Frostell A, Cosgrave EF, Struwe WB, Potter O, Davey GP, Karlsson R, Anneren C, Rudd PM.

(9) FcγRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor MicroenvironmentCancer immunology researchJanuary 1, 0001"Knorr DA, Blanchard L, Leidner RS, Jensen SM, Meng R, Jones A, Ballesteros-Merino C, Bell RB, Baez M, Marino A, et al."Sino Biological), and recombinant human FcγRs (human FCGR2A #10374-H08H, human FCGR2B #10259-H08H, human FCGR3A #10389-H08H, Sino Biological). Ninety-six–well ELISA Half Area High Binding plates (#675061, Greiner Bio-One) were

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Human CD16a / FCGR3A Protein (176 Phe, His Tag)

Human CD16a / FCGR3A Protein (176 Phe, His Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human CD16a / FCGR3A Protein (176 Phe, His Tag) from Sino Biological, Inc.

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