Human R-Spondin 1 / RSPO1 Protein 11083-HNAS from Sino Biological, Inc.

Product Specs
ItemHuman R-Spondin 1 / RSPO1 Protein
CompanySino Biological, Inc.
Price $2,268.00Supplier Page View Company Product Page
Catalog Number11083-HNAS
Conjugate/TagUnconjugated
Purity≥ 95 % as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC
Size1 mg
FormatLyophilized from sterile PBS, PH 7.4
Activity1.Measured by its ability to induce activation of ßcatenin response in a Topflash Luciferase assay using HEK293T human embryonic kidney cells. The ED50 for this effect is typically 10-80 ng/mL in the presence of 5 ng/mL recombinant mouse Wnt3a. 2.Human intestinal cancer organoids were cultured with RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 3.Human colorectum organoids were cultured with RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 4.Human lung cancer organoids were cultured with FGF2(Cat#10014-HNAE), FGF4(Cat#16043-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 5.Human lung organoids were cultured with FGF2(Cat#10014-HNAE), FGF4(Cat#16043-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 6.Human cholangiocarcinomas organoids were cultured with FGF2(Cat#10014-HNAE), HGF(Cat#10463-HNAS), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 7.Human liver cancer organoids were cultured with FGF2(Cat#10014-HNAE), HGF(Cat#10463-HNAS), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), TGFB1(Cat#10804-HNAC), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 8.Human kidney cancer organoids were cultured with FGF2(Cat#10014-HNAE), FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 9.Human kidney organoids were cultured with FGF7(Cat#10210-H07E), EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS), HGF(Cat#10463-HNAS), FGF4(Cat#16043-HNAE). (Routinely tested). Data provided by D1 Medical Technology. 10.Human gastric cancer organoids were cultured with EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 11.Human stomach organoids organoids were cultured with EGF(Cat#50482-MNCH), FGF10(Cat#10573-HNAE), NOG(Cat#50688-M02H), RSPO1(Cat#11083-HNAS). (Routinely tested). Data provided by D1 Medical Technology. 12.Human breast cancer organoids were cultured with FGF7(Cat#10210-H07E), RSPO1(Cat#11083-HNAS), IGF1(Cat#10598-HNAE), EGF(Cat#50482-MNCH), NRG1 Beta 1(Cat#11609-H01H), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology. 13.Human ovarian organoids were cultured with IGF1(Cat#10598-HNAE), NRG1 Beta 1(Cat#11609-H01H), RSPO1(Cat#11083-HNAS), EGF(Cat#50482-MNCH), NOG(Cat#50688-M02H). (Routinely tested). Data provided by D1 Medical Technology
Source/Expression SystemCHO Stable Cells
Molecule NameRSPO1
SpeciesHuman
Molecular WeightThe recombinant human RSPO1 consists of 243 amino acids and has a predicted molecular mass of 26.8 kDa. As a result of glycosylation, the apparent molecular mass of it is approximately 40 and 31 kDa in SDS-PAGE under reducing conditions
TypeRecombinant protein

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Non-invasive in vivo monitoring of transplanted human intestinal organoids using bioluminescenceSurgery open scienceJune 1, 2026Moneme C, da Silva AVA, Obidike PC, Hogg BA, Brousseau GB, Robinson C, Roig-Laboy C, de Sousa JK, Zhang Y, Cheng LS, et al.supplemented with 50 ng/mL rhEGF (Sinobiological, #GMP-10605-HNAE), 500 ng/mL rhRSpondin1 (Sinobiological, #11083-HNAS), and 100 ng/mL rhNoggin (Sinobiological, #10267-HNAH). Kidney capsule transplantation Ten adult NOD-SCID

(2) Robust transcriptomic hallmarks targeting intratumor heterogeneity in intrahepatic cholangiocarcinomaCell reports. MedicineApril 21, 2026Lin Y, Peng L, Zhao H, Lin P, Chen L, Gong Z, Lin J, Liu D, Yang X, Song X, et al.(Gibco, 17502048), 1.25 mM N-acetylcysteine (Sigma, A9165), 500 ng/mL R-spondin 1 (Sino Biological, 11083-HNAS), 25 ng/mL Noggin (Sino Biological, 50688-M02H), 10 mM nicotinamide (Sigma, N0636), 10 nM Gastrin (Sigma,

(3) Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasisCell stem cellApril 2, 2026Rao X, Wang J, Qiao Z, Hong L, Qiao M, Ni L, Song A, Deng Y, Zhao X, Meng J, et al.

(4) Miniature and versatile genome regulation TnpB-ωRNA toolkits facilitate cancer immunotherapyNature CommunicationsApril 1, 2026Junlin Lu, Jiajian Lai, Liang Cheng, Hengji Zhan, Kaiwen Jie, Chu Liu, Lin Huang, Meifeng Cen, Sen Liu, Zehua Chen, et al.SB202190 (10 μM, MCE, HY-10295), A83-01 (500 nM, MCE, HY-10432), R-spondin 1 (500 ng/ml, SinoBiological, 11083-HNAS), HGF (50 ng/ml, SinoBiological, 10463-HNAS), FGF4 (50 ng/ml, Novoprotein, CR08), and FGF10 (10 ng/ml,

(5) Generation and Genetic Manipulation of Human Cervical OrganoidsJournal of visualized experiments : JoVEMarch 10, 2026Choi Y, Myeong J, Oh Chong G, Jeong Y.

(6) Chemotherapy triggers immune evasion by fostering LEPR(+) Kupffer cell differentiation in liver metastasesCancer cellMarch 9, 2026Wang X, Pan Q, Li Y, Li N, Guo J, Gu Y, Zhang G, Lian Y, Liu H, Cao L, et al.

(7) Patient-derived organoids guide personalized therapy for KRAS-mutant pancreatic cancer: synergistic MEK/mTOR inhibition and predictive chemotherapy responsesFrontiers in immunologyJanuary 1, 2026Wang X, Liu L, Li F, Da Y, Hu F, Qi X, Pan Y, Jiang M, Hou P, Yang J.(50×),Gibco,12587010 Nicotinamide,Sigma-Aldrich,N0636-100G N-Acetyl-L-cysteine,Sigma-Aldrich,A9165-5G "RSPO1 protein, human, recombinant",Sino Biological,11083-HNAS Human EGF,Peprotech,AF-100-15 "Noggin protein, human, recombinant",Sino Biological,10267-HNAH Gastrin

(8) Comprehensive dissection of rectal cancer organoids in responses to chemoradiationCell Reports MedicineOctober 21, 2025Xiaoya Xu, Tao Lv, Ye Yao, Juefeng Wan, Lijun Shen, Fan Xia, Xiaoxue Gao, Yuanchuang Li, Guoxiang Fu, Yun Deng, et al.recombinant proteins" ,, Advanced DMEM/F12,Gibco,Cat# 12634-010 R-spondin 1,Sino Biological,Cat# 11083-HNAS Noggin,Sino Biological,Cat# 50688-M02H R-spondin 1,EnaMab,Cat# ERSP1000 Noggin,EnaMab,Cat# ENGG0100 Wnt3a,EnaMab,Cat#

(9) AF6 regulates intestinal IgA via crosstalk between intestinal epithelial cells and immune cells in inflammatory bowel diseaseiScienceJuly 18, 2025Liying Lu, Keying Xu, Huiheng Qu, Lele Song, Yanan Song, Yanjun Wu, Xia Sun, Jingwen Kong, Qian Wen, Jiazheng Jiao, et al.Membrane Matrix,Corning,Cat#354230 Recombinant Human R-spondin1/RSPO1 protein,Sino Biological,Cat#11083-HNAS Recombinant Mouse Noggin/NOG protein (hFc Tag),Sino Biological,Cat#50688-M02H Recombinant Mouse EGF

(10) Dose response test of patient-derived cancer organoids to irradiationFrontiers in oncologyJanuary 1, 2025Yu H, Lin C, Chen F, Chen L, Liu W, Liu H, Li J, Yao Y.(Gibco, 12634-010), 100 ng/mL Noggin (Sino Biological, 50688), 500 ng/mL R-spondin1 (Sino Biological, 11083-HNAS), 1% HEPES, 50 ng/mL EGF (Sino Biological, 50482-MNCH), 1% GlutaMAX, 1:500 gentamicin/amphotericin B

(11) Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapyCancer cellDecember 9, 2024Yang C, Geng H, Yang X, Ji S, Liu Z, Feng H, Li Q, Zhang T, Zhang S, Ma X, et al.

(12) Characterizing the effects of triclosan and triclocarban on the intestinal epithelial homeostasis using small intestinal organoidsJournal of hazardous materialsNovember 5, 2024Cheng X, Shen H, Zhang W, Chen B, Xu S, Wu L.

(13) The combination of breast cancer PDO and mini-PDX platform for drug screening and individualized treatmentJournal of cellular and molecular medicineMay 1, 2024Cui Y, Ran R, Da Y, Zhang H, Jiang M, Qi X, Zhang W, Niu L, Zhou Y, Zhou C, et al.

(14) Unveiling Epigenetic Vulnerabilities in Triple-Negative Breast Cancer through 3D Organoid Drug ScreeningPharmaceuticals (Basel, Switzerland)February 8, 2024Rao X, Qiao Z, Yang Y, Deng Y, Zhang Z, Yu X, Guo X.unavailability and instability in our laboratory, we opted for commercial alternatives: 250 ng/mL Rspo1 (#11083-HNAS; Sino Biological Inc., Beijing, China) and 100 ng/mL Noggin (#50688-M02H; Sino Biological Inc.). Additionally,

(15) Feedback activation of EGFR/wild-type RAS signaling axis limits KRAS(G12D) inhibitor efficacy in KRAS(G12D)-mutated colorectal cancerOncogeneMay 1, 2023Feng J, Hu Z, Xia X, Liu X, Lian Z, Wang H, Wang L, Wang C, Zhang X, Pang X.Advanced DMEM/F12 medium containing 100 U/mL P/S, 10 mM HEPES, 2 mM Glutamine, 50 mg/mL R-spondin-1 (11083-HNAS, Sino Biological, Houston, USA), 100 ng/mL Noggin (50688-M02H, Sino Biological), 1 × B27 supplement

(16) Patient-Derived Organoid Model in the Prediction of Chemotherapeutic Drug Response in Colorectal CancerACS biomaterials science & engineeringAugust 8, 2022Hao M, Cao Z, Wang Z, Xin J, Kong B, Xu J, Zhang L, Chen P.

(17) Molecular Biomarker of Drug Resistance Developed From Patient-Derived Organoids Predicts Survival of Colorectal Cancer PatientsFrontiers in OncologyMarch 29, 2022Lifeng Chen, Bo Tian, Wen Liu, Haitao Liang, Yong You, Weizhen Liu17502-048), 1× B27 supplement (Invitrogen, 17504-044), 500 ng/ml R-spondin 1 (Sino Biological Inc., 11083-HNAS), 100 ng/ml Noggin (Sino Biological Inc., 50688-M02H), 50 ng/ml epidermal growth factor (EGF) (Sino Biological Inc

(18) Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem CellsStem cell reportsJanuary 12, 2021Li Y, Rao X, Tang P, Chen S, Guo Q, Fu G, Pan M, Liang L, Yao Y, Gao X, et al.50482-MNCH), 100 ng/mL Noggin (Sino Biological, 50688-M02H), and 500 ng/mL R-spondin1 (Sino Biological, 11083-HNAS). Organoids were monitored and imaged under microscopy (Zeiss, Vert.A1). The number and size of surviving

(19) Organoid modelling identifies that DACH1 functions as a tumour promoter in colorectal cancer by modulating BMP signallingEBioMedicineJune 1, 2020Hu X, Zhang L, Li Y, Ma X, Dai W, Gao X, Rao X, Fu G, Wang R, Pan M, et al.

(20) Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal CancerCell stem cellJanuary 2, 2020Yao Y, Xu X, Yang L, Zhu J, Wan J, Shen L, Xia F, Fu G, Deng Y, Pan M, et al.

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Organoid Technology in Drug Discovery
March 21, 2024
High-quality products are essential to culture, manipulate, and characterize these complex multicellular model systems read more

Human R-Spondin 1 / RSPO1 Protein

Human R-Spondin 1 / RSPO1 Protein

Human R-Spondin 1 / RSPO1 Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Human R-Spondin 1 / RSPO1 Protein from Sino Biological, Inc.

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