Human IL17 / IL17A Protein 12047-HNAS from Sino Biological, Inc.

Product Specs
ItemHuman IL17 / IL17A Protein
CompanySino Biological, Inc.
Price $58.00Supplier Page View Company Product Page
Catalog Number12047-HNAS
Conjugate/TagUnconjugated
Purity≥ 85 % as determined by SDS-PAGE, ≥ 90 % as determined by SEC-HPLC, ≥ 90% as determined by SEC-MALS(Routinely tested)
TypeRecombinant protein
Molecular WeightThe recombinant human IL17A consists of 132 amino acids and predicts a molecular mass of 15.1 KDa. It migrates as an approximately 16, 19, and 20 KDa band in SDS-PAGE under reducing conditions due to different glycosylation.The molecular weight of this protein is around 31.6kDa verified by SEC-MALS (Routinely tested)
SpeciesHuman
Molecule NameIL17A
Source/Expression SystemCHO Stable Cells
NCBI Full Gene Nameinterleukin 17A
NCBI Gene AliasesCTLA-8, CTLA8, IL-17, IL-17A, IL17, ILA17
Activity1. Measured by its binding ability in a functional ELISA. Immobilized human IL17A (cat:12047-HNAS) at 10 µg/ml (100 µl/well) can bind human IL17Ra (Cat:10895-H03H), The EC50 of human IL17Ra (Cat:10895-H03H) is 20.0-48.0 ng/ml. 2. Measured by its ability to induce IL-6 secretion by NIH-3T3 mouse embryonic fibroblast cells in the presense of 20ng/mL TNFα. The ED50for this effect is 0.2-1ng/mL. 3. Anti-IL17A (Research Grade Ixekiz*mab Biosimilar) captured on Protein A chip can bind Recombinant Human IL-17A Protein (Cat. No. 12047-HNAS) with an affinity constant of 9.13 pM as determined in an SPR assay (Biacore 8K) (Routinely tested) 4.Recombinant Human IL-17RA Protein, hFc Tag (Cat. No. 10895-H02H) captured on Protein A chip can bind Recombinant Human IL-17A Protein (Cat. No. 12047-HNAS) with an affinity constant of 1.390 nM as determined in an SPR assay (Biacore 8K) (Routinely tested). 5.Anti-IL17A (Research Grade Secukin*mab Biosimilar) captured on Protein A chip, can bind Recombinant Human IL-17A Protein (Cat. No. 12047-HNAS) with an affinity constant of 0.144 nM as determined in an SPR assay (Biacore T200) (Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
Size5 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Dual blockade of IL-17A and IL-36 pathways via a bispecific antibody exhibits enhanced anti-inflammatory potencyFrontiers in immunologyJanuary 1, 2024Ma X, Zhang S, Ren X, Feng Y, Li H, Chen S, Xu J, Wang Y, Peng GY, Yan Q, et al.in 50 μL volume at 2.0 × 104 cells/well. The mixture of 10 ng/mL human IL-17A (Sino Biological, Cat#12047-HNAS), 10 ng/mL human TNF-α (Sino Biological, Cat#10602-HNAE) and serial diluted mAb/BsAb were added to the

(2) Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in Autoimmune DiseasesJournal of immunology (Baltimore, Md. : 1950)May 15, 2021He R, Wu S, Gao R, Chen J, Peng Q, Hu H, Zhu L, Du Y, Sun W, Ma X, et al.

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Human IL17 / IL17A Protein

Human IL17 / IL17A Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Human IL17 / IL17A Protein from Sino Biological, Inc.

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