Human EGF / Epidermal Growth Factor Protein 10605-HNAE from Sino Biological, Inc.

Product Specs
ItemHuman EGF / Epidermal Growth Factor Protein
CompanySino Biological, Inc.
Price $58.00Supplier Page View Company Product Page
Catalog Number10605-HNAE
Size100 µg
Conjugate/TagUnconjugated
Purity≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
Activity1.iPSC-derived human vascular organoids (Day 7) were cultured with FGF2 (Cat#10014-HNAE), VEGFA (Cat# 11066-HNAH), EGF (Cat#10605-HNAE). Red arrows represent vascular organoids. Image taken at 10x magnification.(Routinely tested) 2.Measured in a cell proliferation assay using Balb/C 3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 0.02-0.2ng/ml. 3.Western blot analysis of extracts from serum-starved Hela, untreated (-) or treated with EGF (Cat # 10605-HNAE)(10 ng/mL, 30min) using Phospho-EGF Receptor (Tyr1068) rabbit monoclonal Antibody (Cat# 110463-R0027) at 1:2000 dilution (upper), or Anti-EGFR Antibody, Rabbit Polyclonal (Cat# 100372-T32) at 1:2000 dilution (lower)(Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
TypeRecombinant protein
Molecular WeightThe recombinant human EGF consisting of 54 amino acids and has a calculated molecular mass of 6.35 kDa as estimated in SDS-PAGE under reducing conditions
SpeciesHuman
Molecule NameEGF
Source/Expression SystemE. coli

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Activation of the Hippo Pathway by ATN Suppresses Cancer Stem-Like Properties and EGFR-Associated Signaling in Castration-Resistant Prostate Cancer Cells in vitroInt J Med SciMay 1, 2026Kuan-Jung Lin, Jui-Ming Liu, Hsiang-Wen Lin, Jing-Ru Weng, Eman M. E. Dokla, Meng-Tien Lu, Po-Chen Chuincubator containing 5% CO2. Recombinant human EGF was obtained from Sino Biological (Beijing, China, Cat#10605-HNAE). The YAP (1:1000, Cat#14074), c-Myc (1:1000, Cat#5605), NFκB (1:1000, Cat#8242), p-S397-YAP (1:1000,

(2) HDHD5 promotes triple-negative breast cancer growth and drives EMT-associated phenotypes via regulating S100A4J Cancer Res Clin OncolApril 29, 2026Jia-Yang Cai, Yin-Ling Zhang, Fang-Lin Zhang, Qian Zhao, Meng-Ke Ma, Zhi-Min Shaowith 5% donor horse serum (Gibco, #16050-114), epidermal growth factor (20 ng/mL; Sino Biological, #10605-HNAE), hydrocortisone (0.5 mg/mL; Yeasen, #40109ES08), recombinant human insulin (10 mg/mL; Yeasen, #40107ES76),

(3) TUT1-catalyzed U6 snRNA 3′-end maturation is essential for RNA splicing and stem cell survivalEMBO ReportsApril 9, 2026Yin Fang, Tong Qiu, Hong Luo, Yan Wang, Chao Yang, Min Wang, Qian Dai, Wenyue Zheng, Rutie Yin, Xue Xiao, et al.other reagents" DMEM/F12,,"Gibico, 11320-033" N2,,17502048 B27,,17504044 EGF,,"Sino Biological, 10605-HNAE" bFGF,,"Sino Biological, 10014-HNAE" 5-BrdU,,"Sigma, B5002" Accutase,,"Gibico, A1110501" qPCRmix

(4) Enhanced P-TEFb activity compromises dentate gyrus neurogenesis in miceThe EMBO JournalMarch 23, 2026Yin Fang, Tong Qiu, Ping Wang, Shujun Bai, Min Wang, Chao Yang, Yan Wang, Peixuan Zhang, He Wang, Shanling Liu, et al.reagents" Flavopiridol,,"MCE, HY-10005" DMEM/F12,,"Gibico, 11320-033" N2,,17502048 B27,,17504044 EGF,,"Sino Biological, 10605-HNAE" bFGF,,"Sino Biological, 10014-HNAE" 5-BrdU,,"Sigma, B5002" Accutase,,"Gibico, A1110501" qPCRmix

(5) C-terminus CD28 phosphorylation (Y218) modulates IL-2 secretion and antitumor effect of CAR-T cellsbioRxivFebruary 6, 2026Elena Martinez-Planes, Maria Cecilia Ramello, Miguel G. Fontela, Mohammad-Reza Shokri, Lancia Darville, John Koomen, Youngchul Kim, Daniel Abate-Dagang/ml hydrocortisone (Sigma Aldrich, 3867), 10 ng/ml mouse epidermal growth factor (SinoBiological, 10605-HNAE), and 5% fetal bovine serum. PSCA deficient HPAC cells (HPACPSCA-KO) were generated by Synthego (CA,

(6) CD80-Mediated T-Cell Suppression by Cancer Stem-like Cells in Head and Neck Squamous Cell CarcinomaCellsJanuary 30, 2026Mian Xiao, Lin Qiu, Qian Gao, Ruifeng Li, Jing Wang, Yanrui Feng, Xuefen Li, Xiyuan GeCat#11330-032) supplemented with 20 ng/mL human recombinant EGF (SinoBiological, Beijing, China, Cat#10605-HNAE), 20 ng/mL human recombinant bFGF (SinoBiological, Beijing, China, Cat#10014-HNAE), 1% B-27 (Thermo

(7) A genome-wide genetic screen reveals the P2Y2-integrin axis as a stabilizer of EGFR mutants in non–small cell lung cancer (NSCLC)Science AdvancesJanuary 23, 2026Yafei Du, Wenjing Wang, Hui Chin Goh, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Yu-Chun Hsiao, Cheng Chun Wang, Vanisha Agrawal, Noorul Farzana Mohideen, Norhidayah Binte Mohd Mazian, et al.(SCBT, sc-2357) and m-IgGκ BP-HRP (SCBT, sc-516102); recombinant human EGF (Sino Biological, cat. no. 10605-HNAE); ATP (Sigma-Aldrich, cat. no. A1852); apyrase (Sigma-Aldrich, cat. no. A6535); RGDS peptide (Sigma-Aldrich,

(8) CPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cellsCommunications biologyFebruary 16, 2025Zhu Y, Chen S, Su H, Meng Y, Zang C, Ning P, Hu L, Shao H.medium (Gibco) enriched with ITS insulin (#41400045, Gibco) and 0.4% BSA (#B2064, Sigma), 20 ng/mL EGF (#10605-HNAE, Sino Biological), 20 ng/mL basic FGF (#10014-HNAE, Sino Biological) and 12 ng/mL LIF (#14890-HNAH,

(9) Network Pharmacology Approach and Experimental Verification to Explore the Anti-NSCLC Mechanism of Grifolic AcidInt J Mol SciJanuary 13, 2025Xiangdan Cuan, Jingxian Wang, Yue Zhao, Jingyun Yan, Jun Sheng, Yanping Huang(MTT) was obtained from Sigma–Aldrich (M2128, Louis, MO, USA). EGF was obtained from Sino Biological (10605-HNAE, Beijing, China). All compounds were purchased from BioBioPha (Kunming, Yunnan, China). Epidermal growth

(10) STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancerBiology directJuly 30, 2024Liu X, Chen Y, Li Y, Bai J, Zeng Z, Wang M, Dong Y, Zhou Y.

(11) A LATS2 and ALKBH5 positive feedback loop supports their oncogenic rolesCell reportsApril 23, 2024Cao L, Han R, Zhao Y, Qin X, Li Q, Xiong H, Kong Y, Liu Z, Li Z, Dong F, et al.

(12) TMED2 promotes glioma tumorigenesis by being involved in EGFR recycling transportInternational journal of biological macromoleculesMarch 1, 2024Sun C, Zhang Y, Wang Z, Chen J, Zhang J, Gu Y.

(13) Cholesterol-dependent homeostatic regulation of very long chain sphingolipid synthesisThe Journal of cell biologyDecember 4, 2023Kim Y, Mavodza G, Senkal CE, Burd CG.incubated in 10 μM Gefitinib for 18 h (Zheng et al., 2019) prior to initiating pacSph labeling. For EGF (10605-HNAE, Sino Biological) treatment, the cells were incubated in DMEM for 16 h, given 3 μM pacSph in DMEM for

(14) Mannose antagonizes GSDME-mediated pyroptosis through AMPK activated by metabolite GlcNAc-6PCell researchDecember 1, 2023Ai YL, Wang WJ, Liu FJ, Fang W, Chen HZ, Wu LZ, Hong X, Zhu Y, Zhang CX, Liu LY, et al.were purchased from Aladdin. Human TNF-α protein (Cat# 10602-HNAE) and recombinant murine EGF (Cat# 10605-HNAE) were purchased from Sino Biological. Protease inhibitor cocktail (Cat# K1007), phosphatase inhibitor

(15) TRAF7-targeted HOXA5 acts as a tumor suppressor in prostate cancer progression and stemness via transcriptionally activating SPRY2 and regulating MEK/ERK signalingCell death discoveryOctober 16, 2023Ye J, Liu W, Yu X, Wu L, Chen Z, Yu Y, Wang J, Bai S, Zhang M.cultured in DMEM/F12 (BL305A, Biosharp, China) containing 20 ng/mL of epidermal growth factor (EGF, 10605-HNAE, Sino Biological Inc., China), 10 ng/mL of basic fibroblast growth factor (bFGF, 10014-HNAE, Sino Biological Inc

(16) SUMOylation of AnxA6 facilitates EGFR-PKCα complex formation to suppress epithelial cancer growthCell communication and signaling : CCSAugust 1, 2023Sheng Z, Cao X, Deng YN, Zhao X, Liang S.RPMI-1640, fetal bovine serum (FBS) were ordered from Gibco. Human recombinant EGF (Catalog number:10605-HNAE) was bought from Sino Biological company. ML792 (HY-108702), SUMOylation inhibitor 2-D08 (HY-114166),

(17) Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastomaNature communicationsJuly 10, 2023Li Y, Gao Z, Wang Y, Pang B, Zhang B, Hu R, Wang Y, Liu C, Zhang X, Yang J, et al.(S7208), and U0126 (S1102) were purchased from Selleck Chemicals. EGF was acquired from Sino Biological (10605-HNAE). Generation of stable cells using lentiviral transfection Stable cell lines were constructed as previously

(18) Sustaining the Activation of EGFR Signal by Inflammatory Cytokine IL17A Prompts Cell Proliferation and EGFR-TKI Resistance in Lung CancerCancersJune 22, 2023Lee KL, Lai TC, Lee WJ, Chen YC, Ho KH, Hung WY, Yang YC, Chan MH, Hsieh FK, Chung CL, et al.from Prospec (Ness-Ziona, Israel) and R&D Systems (Minneapolis, MN, USA). The human recombinant EGF (10605-HNAE) was obtained from Sino Biological (Beijing, China). Afatinib was purchased from Sigma Chemical (St.

(19) A drug screening to identify novel combinatorial strategies for boosting cancer immunotherapy efficacyJournal of translational medicineJanuary 13, 2023Zhang Z, Wang G, Zhong K, Chen Y, Yang N, Lu Q, Yuan B, Wang Z, Li H, Guo L, et al.(Thermo Fisher Scientific, Cat# 17504044), 10 ng /mL human recombinant epidermal growth factor EGF (Sino Biological, Cat# 10605-HNAE), and 10 ng /mL human recombinant fibroblast growth factor FGF (Sino Biological, Cat# 10573-HNAE) for

(20) Inositol monophosphatase 1 (IMPA1) promotes triple-negative breast cancer progression through regulating mTOR pathway and EMT processCancer medicineJanuary 1, 2023Yang SY, Xie YF, Zhang TM, Deng L, Liao L, Hu SY, Zhang YL, Zhang FL, Li DQ.containing 5% donor horse serum (Gibco, #16050–114), 20 ng/ml epidermal growth factor (Sino Biological Inc, #10605 HNAE), 0.5 mg/ml hydrocortisone (Yeasen, #40109ES08), 10 mg/ml human recombinant insulin (Yeasen, #40107ES76),

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Reasons to Consider Recombinant Growth Factors for Organoid Research
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Human EGF / Epidermal Growth Factor Protein

Human EGF / Epidermal Growth Factor Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Reasons to Consider Recombinant Growth Factors for Organoid Research

Human EGF / Epidermal Growth Factor Protein from Sino Biological, Inc.

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