Human MMP-2 / CLG4A Protein 10082-HNAH from Sino Biological, Inc.

Product Specs
ItemHuman MMP-2 / CLG4A Protein
CompanySino Biological, Inc.
Price $138.00Supplier Page View Company Product Page
Catalog Number10082-HNAH
Activity1. Measured by its ability to cleave the fluorogenic peptide substrate Mca-PLGL-Dpa-AR-NH2 (AnaSpec, Catalog # 27076). The specific activity is > 1,000 pmoles/min/µg. (Activation description: The proenzyme needs to be activated by APMA for an activated form) 2. Measured by its binding ability in a functional ELISA. Immobilized Human MMP-2 (Cat:10082-HNAH) at 2 µg/ml (100 µl/well) can bind Human TIMP2 hFc(Cat:10396-H01H), the EC50 of Human TIMP2 hFc is 6.0-30.0 ng/mL
FormatLyophilized from sterile 0.05 % Brij-35, 150 mM NaCl, 5 mM CaCl2, 50 mM Tris, pH 7.5
Source/Expression SystemHEK293 Cells
Molecule NameMMP2
SpeciesHuman
Molecular WeightThe recombinant human MMP2 consists of 631 amino acids and migrates as an 72 kDa band as predicted in SDS-PAGE under reducing conditions
TypeRecombinant protein
Purity≥ 90 % as determined by SDS-PAGE ≥ 90 % as determined by SEC-HPLC
Conjugate/TagUnconjugated
Size20 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) Universal Fab-Fc masked cytokine prodrug platform: αPD-L1/IL-15 prodrug activates CD44+ CD8+ T cells in tumor-draining lymph nodes to enhance antitumor immunityJournal for ImmunoTherapy of CancerJuly 31, 2025Luyao Song, Gen Qi, Wenqiang Shi, Qiongya Zeng, Ying Qin, Zejian Wang, Wei Li, Zilan Song, Ao Zhang, Huili LuCat#PR1200), SulfoCy5.5 SE (Fluorescence, Cat#1057–1 mg), Human MMP-2/CLG4A Protein (Sino Biological, Cat#10082-HNAH), FTY720 (Sigma-Aldrich, Cat#162359-56-0), Fixable Viability Stain 510 (BD Pharmingen, Cat#564406),

(2) Probiotic-mediated tumor microenvironment reprogramming with protease-sensitive interleukin-15 and photothermal therapyCell Rep MedJune 17, 2025Huifang Wang, Liuhai Zheng, Chuanbin Yang, Lin Jia, Runhua Zhou, Hongda Liu, Yafang Dong, Xiaolong Xu, Guangwei Shi, Jialu Yang, et al.recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, MMP2,Sino Biological,Cat#10082-HNAH MMP9,Sino Biological,Cat#10327-HNAH uPA,Sino Biological,Cat#10815-H08H p-aminophenylmercuric acetate,Sigma,Cat#A9563 IL-15,Abclonal,Cat#RP01676 EDC,Sigma,Cat#

(3) Antigen‐Targeting Inserted Nanomicelles Guide Pre‐Existing Immunity to Kill Head and Neck CancerAdvanced ScienceMarch 17, 2025Lizhuo Zhang, Qingqing Feng, Chuanming Zheng, Yuanqiang Li, Xinyang Ge, Tiefeng Jin, Gaofeng Hu, Zhuo Tan, Jiafeng Wang, Jiajie Xu, et al.China Peptides Co., Ltd. (Shanghai, China). Recombinant MMP‐2 Protein (Sino Biological, China, Cat: 10082‐HNAH) was purchased from Sino Biological Co., Ltd. China. P‐aminophenyl‐mercuric acetate (APMA, GENMED, USA,

(4) A matrix metalloproteinase-responsive hydrogel system controls angiogenic peptide release for repair of cerebral ischemia/reperfusion injuryNeural Regeneration ResearchFebruary 1, 2025Qi Liu, Jianye Xie, Runxue Zhou, Jin Deng, Weihong Nie, Shuwei Sun, Haiping Wang, Chunying Shiwas set with three parallel holes. Next, 100 nM MMP-2 (50 μL/well, SinoBiological, Beijing, China, 10082-hnah) was added to the 96-well plate containing the biotin-labeled PA-TIMP-QK and biotin-labeled PA-QK peptides.

(5) Integrating molecular dynamics simulation with small‐ and wide‐angle X‐ray scattering to unravel the flexibility, antigen‐blocking, and protease‐restoring functions in a hindrance‐based pro‐antibodyProtein ScienceSeptember 1, 2024Jun Min Liao, Shih‐Ting Hong, Yeng‐Tseng Wang, Yi‐An Cheng, Kai‐Wen Ho, Shu‐Ing Toh, Orion Shih, U‐Ser Jeng, Ping‐Chiang Lyu, I‐Chen Hu, et al.for the LC. 1.11 μg of pro‐Nivolumab IgG was incubated with 2 ng of activated MMP‐2 (Sino Biological, 10082‐HNAH, the specific activity is >1000 pmoles/min/μg with fluorogenic peptide substrate Mca‐PLGL‐Dpa‐AR‐NH2

(6) Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicityCell reports. MedicineMay 21, 2024Shi W, Liu N, Liu Z, Yang Y, Zeng Q, Wang Y, Song L, Hu F, Fu J, Chen J, et al.PD-L1,Novoprotein,Cat#: C315 Urokinase/uPA,SinoBiological,Cat#: 10815-H08H Human MMP-2,SinoBiological,Cat#: 10082-HNAH CD122 (IL-2/15Rβ),SinoBiological,Cat#: 10696-H08B TMB single component substrate solution,Solarbio,Cat#:

(7) Engineering a tumor-selective prodrug T-cell engager bispecific antibody for safer immunotherapymAbsJanuary 1, 2024McCue AC, Demarest SJ, Froning KJ, Hickey MJ, Antonysamy S, Kuhlman B.incubator at 37°C, 5% CO2. Recombinant human MMP-2 and HER-2 were purchased from Sino Biological (#10082-HNAH, #10004-H08H). Recombinant CD3γε extracellular domain with C-terminal his tag was prepared in-house. Design

(8) In silico evolution of autoinhibitory domains for a PD-L1 antagonist using deep learning modelsProceedings of the National Academy of Sciences of the United States of AmericaDecember 5, 2023Goudy OJ, Nallathambi A, Kinjo T, Randolph NZ, Kuhlman B.antagonists. To activate the pro-MMP-2 protease, pro-MMP-2 (reconstituted to 0.5 mg/ml, Sino Biological, 10082-HNAH) was incubated with equal volumes of 4 mM APMA in TCNB buffer [50 mM Tris, 10 mM CaCl2, 150 mM NaCl,

(9) Enzyme-Triggered Transforming of Assembly Peptide-Modified Magnetic Resonance-Tuned Probe for Highly Sensitive Imaging of Bacterial Infection In VivoSmall (Weinheim an der Bergstrasse, Germany)June 1, 2023Li L, Liu M, Deng S, Zhu X, Song Y, Song E.

(10) An MMP-9 exclusive neutralizing antibody attenuates blood-brain barrier breakdown in mice with stroke and reduces stroke patient-derived MMP-9 activityPharmacological researchApril 1, 2023Ji Y, Gao Q, Ma Y, Wang F, Tan X, Song D, Hoo RLC, Wang Z, Ge X, Han H, et al.zymographic analysis. Recombinant MMP-9 (rMMP-9, #50560-MNAH, Sino Biological, Beijing, China) and rMMP-2 (#10082-HNAH, Sino Biological, Beijing, China) protein was used as positive controls to pinpoint the size of endogenous

(11) An enzyme-responsive and transformable PD-L1 blocking peptide-photosensitizer conjugate enables efficient photothermal immunotherapy for breast cancerBioactive materialsApril 1, 2023Sun Y, Lyu B, Yang C, He B, Zhang H, Wang X, Zhang Q, Dai W.from GL Biochem (China). Purpurin 18 was purchased from Frontier (USA). Recombinant Human MMP-2 (cat# 10082-HNAH) was purchased from Sino Biological (China). Anti-MMP2 Antibody (cat# EPR17003) and anti-PD-L1 Antibody

(12) In situ peptide self-assembly on ionic nanochannel for dynamic monitoring of MMPs in extracellular matrixBiosensors & bioelectronicsJanuary 1, 2022Wang L, Li H, Shi L, Li L, Jia F, Gao T, Li G.

(13) Electrochemical Trans-Channel Assay for Efficient Evaluation of Tumor Cell InvasivenessACS applied materials & interfacesApril 21, 2021Shi L, Wang L, Ma X, Jalalah M, Alsareii SA, Gao T, Harraz FA, Li G.

(14) Alterations of gut microbiota contribute to the progression of unruptured intracranial aneurysmsNature communicationsJune 25, 2020Li H, Xu H, Li Y, Jiang Y, Hu Y, Liu T, Tian X, Zhao X, Zhu Y, Wang S, et al.

(15) A coiled-coil masking domain for selective activation of therapeutic antibodiesNature biotechnologyJuly 1, 2019Trang VH, Zhang X, Yumul RC, Zeng W, Stone IJ, Wo SW, Dominguez MM, Cochran JH, Simmons JK, Ryan MC, et al.

(16) Evaluation of Matrix Metalloproteinase Inhibition by Peptide Microarray-Based Fluorescence Assay on Polymer Brush Substrate and in Vivo AssessmentACS applied materials & interfacesDecember 20, 2017Lei Z, Chen H, Zhang H, Wang Y, Meng X, Wang Z.

(17) Activatable Near-Infrared Probe for Fluorescence Imaging of γ-Glutamyl Transpeptidase in Tumor Cells and In VivoChemistry (Weinheim an der Bergstrasse, Germany)October 20, 2017Luo Z, Feng L, An R, Duan G, Yan R, Shi H, He J, Zhou Z, Ji C, Chen HY, et al.

(18) Peptide Microarray-Based Metal Enhanced Fluorescence Assay for Multiple Profiling of Matrix Metalloproteinases ActivitiesAnalytical chemistryJune 20, 2017Lei Z, Zhang H, Wang Y, Meng X, Wang Z.

(19) Smart Asymmetric Vesicles with Triggered Availability of Inner Cell-Penetrating Shells for Specific Intracellular Drug DeliveryACS applied materials & interfacesMay 31, 2017Li J, Xiao S, Xu Y, Zuo S, Zha Z, Ke W, He C, Ge Z.

(20) Modular Design and Facile Synthesis of Enzyme-Responsive Peptide-Linked Block Copolymers for Efficient Delivery of DoxorubicinBiomacromoleculesOctober 10, 2016Ke W, Li J, Zhao K, Zha Z, Han Y, Wang Y, Yin W, Zhang P, Ge Z.

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Human MMP-2 / CLG4A Protein

Human MMP-2 / CLG4A Protein from Sino Biological, Inc.

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Sino Biological, Inc.

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Human MMP-2 / CLG4A Protein from Sino Biological, Inc.

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