Mouse CTLA4 / CD152 Protein (ECD, Fc Tag) 50503-M02H from Sino Biological, Inc.

Product Specs
ItemMouse CTLA4 / CD152 Protein (ECD, Fc Tag)
CompanySino Biological, Inc.
Price $128.00Supplier Page View Company Product Page
Catalog Number50503-M02H
Conjugate/TagC-human IgG1-Fc
Purity≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe secreted recombinant mouse CTLA4/Fc is a disulfide-linked homodimeric protein. The reduced monomer comprises 368 amino acids and has a predicted molecular mass of 41 kDa. As a result of glycosylation, the apparent molecular mass of rm CTLA4/Fc monomer is approximately 53 kDa in SDS-PAGE under reducing conditions
SpeciesMouse
Molecule NameCTLA4
Source/Expression SystemHEK293 Cells
NCBI Full Gene Namecytotoxic T-lymphocyte-associated protein 4
NCBI Gene AliasesCd152, Ctla-4, Ly-56
FormatLyophilized from sterile PBS, pH 7.4
Activity1.Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. The ED50 for this effect is 0.05-0.3µg/mL when stimulated with 1 µg/mL Recombinant Human B7-1/CD80. 2.Immobilized Recombinant Mouse CD86 / B7-2 Protein (His Tag) (Cat: 50068-M08H) at 2 µg/mL (100 µL/well) can bind Recombinant Mouse CTLA4 / CD152 Protein (ECD, Fc Tag) (Cat: 50503-M02H), the EC50 is 2.0-7.0 ng/mL
Size100 µg

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Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

(1) Combinatorial leaky probiotic for anticancer immunopotentiation and tumor eradicationCell reports. MedicineNovember 19, 2024Liu CH, Pan YC, Lim SK, Mou CY, Hu CJ, Mou KY.

(2) Conditional PD-1/PD-L1 Probody Therapeutics Induce Comparable Antitumor Immunity but Reduced Systemic Toxicity Compared with Traditional Anti-PD-1/PD-L1 AgentsCancer immunology researchDecember 1, 2021Assi HH, Wong C, Tipton KA, Mei L, Wong K, Razo J, Chan C, Howng B, Sagert J, Krimm M, et al.proteins (both human and mouse proteins) including CTLA-4 (Sino Biological, catalogs #11159-H02H6 and #50503-M02H), PD-1 (Sino Biological, catalogs #10377-H02H and #50124-M02H), B7–1 (Sino Biological, catalogs #10698-H02H

(3) Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK CellsCancersAugust 6, 2020Passariello M, Vetrei C, Sasso E, Froechlich G, Gentile C, D'Alise AM, Zambrano N, Scarselli E, Nicosia A, De Lorenzo C.

(4) DNA-Based Delivery of Checkpoint Inhibitors in Muscle and Tumor Enables Long-Term Responses with Distinct ExposureMolecular therapy : the journal of the American Society of Gene TherapyApril 8, 2020Jacobs L, De Smidt E, Geukens N, Declerck P, Hollevoet K.

Mouse CTLA4 / CD152 Protein (ECD, Fc Tag)