Human HER2 / ErbB2 Protein (Fc Tag) 10004-H02H from Sino Biological, Inc.

Product Specs
ItemHuman HER2 / ErbB2 Protein (Fc Tag)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number10004-H02H
Size100 µg
Conjugate/TagC-human IgG1-Fc
Purity≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ≥ 90 % as determined by SEC-MALS(Routinely tested)
Activity1. Immobilized Recombinant Human HER2 / ErbB2 Protein (Fc Tag) (Cat: 10004-H02H) at 0.05 µg/mL (100 µL/well) can bind Trastuzumab derived Anti-Erbb2 antibody, Human IgG1, the EC50 is 10.2-30.8 ng/mL (QC tested). 2. Measured by its ability to block anti-ErbB2 mediated inhibition of BT474 human breast ductal carcinoma cell proliferation. The ED50 for this effect is 0.5-3 µg/mL in the presence of 0.6 µg/mL Anti-ErbB2/Her2 Monoclonal Antibody (Routinely tested)
FormatLyophilized from sterile PBS, pH 7.4
TypeRecombinant protein
Molecular WeightThe recombinant human ErbB2/Fc chimera is a disulfide-linked homodimeric protein generated by proteolytic removal of the signal peptide. The monomer comprises 868 amino acids and has a calculated molecular mass of 96.1 kDa. As a result of glycosylation, the monomer migrates as an approximately 130-140 kDa protein in SDS-PAGE under reducing conditions. The molecular weight of this protein is around 218.9 kDa verified by SEC-MALS (Routinely tested)
SpeciesHuman
Molecule NameERBB2
Source/Expression SystemHEK293 Cells
NCBI Full Gene Nameerb-b2 receptor tyrosine kinase 2
NCBI Gene AliasesCD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2)

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) The critical role of Atpif1 in Her2-targeted CAR-T cell therapy for solid tumor via modulation of metabolism and mtDNA-STING signal pathwayFront ImmunolMarch 2, 2026Genshen Zhong, Biao Liu, Xue Gong, Qi Wang, Shuyin Zheng, Xinyu Luo, Zhiguo Chen, Xingya Zhang, Biliang Hu, Minna Wudays after lentivirus infection, CAR+ cells were analyzed using the biotin-labeled Her2 protein (Cat: 10004-H02H, SinoBiological, China) following the PE-conjugated anti-biotin antibody (Cat: 12-9895-82, eBioscience). For

(2) Engineering high-efficiency matriptase substrates using E. coli display for applications in prodrug activationCell Rep MethodsJune 16, 2025Mestre Borras A, Mehari H, Ståhl S, Löfblom J.proteins","Chemicals, peptides, and recombinant proteins" ,, "HER2/ERBB2 Protein ECD, His Tag",SinoBiologicals,10004-H02H Human serum albumin,Kabivitrum, Alexa Fluor™ 647 NHS Ester,Invitrogen,A20006 Matriptase,R&D systems/Bio-Techne,3946-SEB Urokinase-type

(3) A novel anti-HER2 monoclonal antibody IAH0968 in HER2-positive heavily pretreated solid tumors: results from a phase Ia/Ib first-in-human, open-label, single center studyFrontiers in ImmunologyNovember 29, 2024Na Song, Yuee Teng, Jing Shi, Zan Teng, Bo Jin, Jinglei Qu, Lingyun Zhang, Ping Yu, Lei Zhao, Jin Wang, et al.recognition of HER2 by IAH0968. The capture agent was recombinant Human HER2 Protein (Sino Biological, 10004-H02H), coated onto a microplate. Samples were pipetted into the wells and any IAH0968 present will be bound

(4) Plug-and-play nucleic acid-mediated multimerization of biparatopic nanobodies for molecular imagingMolecular therapy. Nucleic acidsSeptember 10, 2024Teodori L, Ochoa SK, Omer M, Andersen VL, Bech P, Su J, Bridoux J, Nielsen JS, Bertelsen MB, Hernot S, et al.rpm in 96-well plates (black, flat bottom, Greiner). The Fc-Her2 receptor (Sino Biological, cat. no. 10004-H02H), 2 μg/mL, was immobilized on anti-hIgG Fc-capture sensors (Sartorius, 18-5060) by a 600 s loading step.

(5) Identification of actionable targets for breast cancer intervention using a diversity outbred mouse modeliScienceApril 21, 2023Jennifer B. Jacob, Kuang-Chung Wei, Gerold Bepler, Joyce D. Reyes, Andi Cani, Lisa Polin, Kathryn White, Seongho Kim, Nerissa Viola, Julie McGrath, et al.,Miltenyi Biotec,Cat#130-109-398 TRIZOL reagent,ThermoFisher,Cat#15596018 Recombinent HER2-ECD-Fc protein,SinoBiological,Cat#10004-H02H ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, Next GEM

(6) Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugatesNature communicationsFebruary 21, 2023Wang Y, Zhang J, Han B, Tan L, Cai W, Li Y, Su Y, Yu Y, Wang X, Duan X, et al.prepared mixture of 90 mM EDC and 25 mM sulfo-NHS for 5 min, loaded with 20 µg/mL HER2/ERBB2 Protein (10004-H02H, Sino Biological, China) in 10 mM sodium acetate (pH 4.5) for 5 min, and then excess reactive esters

(7) The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor functionCell metabolismMay 3, 2022Wenes M, Jaccard A, Wyss T, Maldonado-Pérez N, Teoh ST, Lepez A, Renaud F, Franco F, Waridel P, Yacoub Maroun C, et al.PE-Cy7,Biolegend,RRID: AB_10644005 recombinant human Fc-tagged Her2/ErbB2 protein,Sino Biological,Cat# 10004-H02H anti-human-Fc Alexa Fluor 488 conjugate,Thermo Fisher Scientific,RRID: AB_2534050 anti-human CD19,Biolegend,RRID:

(8) A novel HER2-targeting antibody 5G9 identified by large-scale trastuzumab-based screening exhibits potent synergistic antitumor activityEBioMedicineOctober 1, 2020Ding X, Gu W, Zhong Y, Hao X, Liu J, Xia S, Luo L, Chen M, Zhang C.was produced by Merck Incorporated. The recombinant proteins huEGFR (Cat# 10001-H02H), huHER2 (Cat# 10004-H02H), huHER3 (Cat# 10201-H02H), huHER4 (Cat# 10363-H02H), rhesus HER2 (Cat# 90020-K02H) and mouse HER2 (Cat#

(9) Site-specific conjugation of recognition tags to trastuzumab for peptide nucleic acid-mediated radionuclide HER2 pretargetingBiomaterialsMay 1, 2019Westerlund K, Vorobyeva A, Mitran B, Orlova A, Tolmachev V, Karlström AE, Altai M.

(10) Generation by phage display and characterization of drug-target complex-specific antibodies for pharmacokinetic analysis of biotherapeuticsmAbsJanuary 1, 2019Harth S, Ten Haaf A, Loew C, Frisch C, Knappik A.generation were: human TNF (recombinant human TNF-α, BioLegend 570108), human ErbB2-Fc (Sino Biological 10004-H02H), human IgE (Bio-Rad HCA171), human VEGF (Bio-Rad, produced in E. coli, amino acids Ala27-Glu140 plus

(11) Efficient production of Trastuzumab Fab antibody fragments in Brevibacillus choshinensis expression systemProtein expression and purificationOctober 1, 2018Mizukami M, Onishi H, Hanagata H, Miyauchi A, Ito Y, Tokunaga H, Ishibashi M, Arakawa T, Tokunaga M.

(12) High affinity single-chain variable fragments are specific and versatile targeting motifs for extracellular vesiclesNanoscaleAugust 7, 2018Longatti A, Schindler C, Collinson A, Jenkinson L, Matthews C, Fitzpatrick L, Blundy M, Minter R, Vaughan T, Shaw M, et al.

(13) A new prodrug form of Affibody molecules (pro-Affibody) is selectively activated by cancer-associated proteasesCellular and molecular life sciences : CMLSApril 1, 2015Sandersjöö L, Jonsson A, Löfblom J.

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Human HER2 / ErbB2 Protein (Fc Tag)

Human HER2 / ErbB2 Protein (Fc Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

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Human HER2 / ErbB2 Protein (Fc Tag) from Sino Biological, Inc.

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