Mouse Legumain/ LGMN Protein (His Tag) 50051-M07H from Sino Biological, Inc.

Product Specs
ItemMouse Legumain/ LGMN Protein (His Tag)
CompanySino Biological, Inc.
Price $298.00Supplier Page View Company Product Page
Catalog Number50051-M07H
Conjugate/TagN-His
Purity≥ 75 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC
TypeRecombinant protein
Molecular WeightThe secreted recombinant mouse LGMN consists of 434 amino acids and has a calculated molecular mass of 49.8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 55 kDa protein in SDS-PAGE under reducing conditions
SpeciesMouse
Molecule NameLGMN
Source/Expression SystemHEK293 Cells
ActivityMeasured by its ability to cleave the fluorogenic peptide substrate, N-carbobenzyloxy-Ala-Ala-Asn-7-amido-4-methyl coumarin(Z-AAN-AMC). The specific activity is > 350 pmoles/min/µg. (Activation description: The enzyme achieves its activity under acidic pH)
FormatSupplied as sterile 25mM Tris, 0.15M NaCl, 20% Glycerol, pH 7.5
Size50 µg

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Sino Biological, Inc.

37 Industrial Blvd

Suite B

Paoli, PA 19301

United States

Phone: 215-583-7898
Fax: 267-657-0217

Email: marketing@sinobiological.com

Company Profile

Website: sinobiological.com

(1) A protease-cleavable liposome for co-delivery of anti-PD-L1 and doxorubicin for colon cancer therapy in miceNature communicationsMarch 24, 2025Liu Y, Xie Y, Chen Y, Duan J, Bao C, Wang J, Feng H, Wang M, Ren Y, Li P, et al.#CC73) were purchased from Novoprotein (Shanghai, China). Recombinant mouse legumain protein (His Tag, #50051-M07H) was purchased from Sino Biological (Beijing, China). InVivoMab anti-mouse PD-L1 (B7-H1) (clone: 10

(2) Cofilin promotes tau pathology in Alzheimer's diseaseCell reportsFebruary 28, 2023Yan M, Tang L, Dai L, Lei C, Xiong M, Zhang X, He M, Tian Y, Xiong J, Ke W, et al.

(3) UNC5C Receptor Proteolytic Cleavage by Active AEP Promotes Dopaminergic Neuronal Degeneration in Parkinson's DiseaseAdvanced science (Weinheim, Baden-Wurttemberg, Germany)March 1, 2022Chen G, Ahn EH, Kang SS, Xia Y, Liu X, Zhang Z, Ye K.Lipofectamine 3000 (Invitrogen, L3000008), and Recombinant Legumain Protein (rAEP, Sino Biological, 50051‐M07H). All other chemicals not included above were purchased from Sigma Aldrich. Plasmids and Viral Vector HA‐UNC5C

(4) Amphiphysin I cleavage by asparagine endopeptidase leads to tau hyperphosphorylation and synaptic dysfunctioneLifeMay 21, 2021Zhang X, Zou L, Meng L, Xiong M, Pan L, Chen G, Zheng Y, Xiong J, Wang Z, Duong DM, et al.T23364 Chemical compound FM 4–64 Thermo Cat # T13320 Protein Recombinant AEP Sino Biological Cat # 50051-M07H Mice Tau P301S mice on a C57BL/6J background (line PS19) and wild-type C57BL/6J mice were from The Jackson

(5) Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologiesScience advancesApril 1, 2021Chen G, Kang SS, Wang Z, Ahn EH, Xia Y, Liu X, Sandoval IM, Manfredsson FP, Zhang Z, Ye K.QuikChange Lightning Site-Directed Mutagenesis Kit (Agilent, 210519), and Recombinant Legumain Protein (Sino Biological, 50051-M07H). The recombinant AEP was first activated by incubation in activation buffer (0.1 M NaOAc, 0.1 M NaCl,

(6) BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKTJCI insightAugust 23, 2018Wang ZH, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, et al.by immunoprecipitation. Recombinant mouse His-tagged AEP proteins were purchased from Sino Biological (50051-M07H). Recombinant human GST-tagged Akt proteins were purchased from Cell Sciences (CRA004A). Substrates

(7) Legumain-cleavable 4-arm poly(ethylene glycol)-doxorubicin conjugate for tumor specific delivery and releaseActa biomaterialiaMay 1, 2017Zhou H, Sun H, Lv S, Zhang D, Zhang X, Tang Z, Chen X.

(8) Site-specific cleavage of acetoacetyl-CoA synthetase by legumainFEBS lettersJune 1, 2016Hasegawa S, Inoue D, Yamasaki M, Li C, Imai M, Takahashi N, Fukui T.

(9) Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidneyBiochemical and biophysical research communicationsOctober 24, 2014Hasegawa S, Yamasaki M, Fukui T.

(10) Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironmentNature communicationsJune 27, 2014Liu Z, Xiong M, Gong J, Zhang Y, Bai N, Luo Y, Li L, Wei Y, Liu Y, Tan X, et al.

(11) Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stageCell researchMarch 1, 2014Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung LW, et al.to confirm functional AEP expression in insect cells were purchased from Sino Biological Inc. (Catalog #: 50051-M07H and 62001W08H, respectively). Mutations were designed based on mouse AEP constructs, and mutagenesis

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Mouse Legumain/ LGMN Protein (His Tag)

Mouse Legumain/ LGMN Protein (His Tag) from Sino Biological, Inc.

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Sino Biological, Inc.

Citations (11)

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Mouse Legumain/ LGMN Protein (His Tag) from Sino Biological, Inc.

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